stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Cisar LA et al. | Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. | 1993 | Cell. Signal. | pmid:8373725 |
Zock PL et al. | Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. | 1993 | Eur J Clin Nutr | pmid:8365385 |
Chigorno V et al. | Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. | 1994 | Eur. J. Biochem. | pmid:8181467 |
Croxtall JD et al. | Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. | 1994 | Biochem. Pharmacol. | pmid:8304964 |
Mitropoulos KA et al. | Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. | 1994 | Arterioscler. Thromb. | pmid:8305411 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Ikeda I et al. | Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7965216 |
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Catalá A et al. | Interaction of rat liver microsomes containing saturated or unsaturated fatty acids with fatty acid binding protein: peroxidation effect. | 1994 | Mol. Cell. Biochem. | pmid:7845387 |
Lu B et al. | Characterization of modified staphylococcal protein A containing phospholipid monolayer on both solution and slide surfaces. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8185601 |
Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
Batten TL et al. | Contact dermatitis from the old formula E45 cream. | 1994 | Contact Derm. | pmid:8187515 |
Rabinowitz JL and Myerson RM | Changes in the lipid content of rat lymph after the ingestion of [14C] long-chain fatty acids. | 1994 | Life Sci. | pmid:8107533 |
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Shoji Y et al. | Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene. | 1994 | J. Pharm. Pharmacol. | pmid:7815276 |
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Young AC et al. | Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. | 1994 | Structure | pmid:7922029 |
Nonogaki T et al. | Developmental blockage of mouse embryos caused by fatty acids. | 1994 | J. Assist. Reprod. Genet. | pmid:7633171 |
Ellingson JS and Seenaiah B | The selective use of stearoyl-polyunsaturated molecular species of phosphatidylcholine and phosphatidylethanolamine for the synthesis of phosphatidylserine. | 1994 | Biochim. Biophys. Acta | pmid:8011673 |
Hoebeke M et al. | Quenching of merocyanine 540 triplet state by nitroxyl radicals in liposomal systems: a laser flash photolysis study. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:8014755 |
Adewusi SR and Ilori MO | Nutritional evaluation of spent grains from sorghum malts and maize grit. | 1994 | Plant Foods Hum Nutr | pmid:7971786 |
Fuller CJ and Jialal I | Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. | 1994 | Am. J. Clin. Nutr. | pmid:7977141 |
Denke MA | Effects of cocoa butter on serum lipids in humans: historical highlights. | 1994 | Am. J. Clin. Nutr. | pmid:7977142 |
Emken EA | Metabolism of dietary stearic acid relative to other fatty acids in human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977144 |
Kris-Etherton PM and Mustad VA | Chocolate feeding studies: a novel approach for evaluating the plasma lipid effects of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977145 |
Dougherty RM et al. | Total and low-density-lipoprotein cholesterol lipoprotein fractions and fecal fatty acid excretion of men consuming diets containing high concentrations of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977147 |
Denke MA | Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet. | 1994 | Am. J. Clin. Nutr. | pmid:7977148 |
Hoak JC | Stearic acid, clotting, and thrombosis. | 1994 | Am. J. Clin. Nutr. | pmid:7977149 |
Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
Schoene NW et al. | Dissimilar responses of platelets to dietary stearic and palmitic acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977151 |
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Vanderveen JE | Regulatory history for stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977156 |
Kritchevsky D | Stearic acid metabolism and atherogenesis: history. | 1994 | Am. J. Clin. Nutr. | pmid:7977159 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Grundy SM | Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977157 |
Redgrave TG et al. | The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. | 1994 | Biochim. Biophys. Acta | pmid:8117751 |
Rule DC | Effects of dietary fatty acid composition on glycerophosphate acyltransferase activity in rat adipose tissue and liver. | 1994 | Int. J. Biochem. | pmid:8138047 |
Golovina EA and Tikhonov AN | The structural differences between the embryos of viable and nonviable wheat seeds as studied with the EPR spectroscopy of lipid-soluble spin labels. | 1994 | Biochim. Biophys. Acta | pmid:8142440 |
Sargent JR et al. | Nervonic acid and demyelinating disease. | 1994 | Med. Hypotheses | pmid:8072429 |
Sylvester PW et al. | Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. | 1994 | Exp. Cell Res. | pmid:8082717 |
Wonsil BJ et al. | Dietary and ruminally derived trans-18:1 fatty acids alter bovine milk lipids. | 1994 | J. Nutr. | pmid:8145078 |
Tholstrup T et al. | Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. | 1994 | Am. J. Clin. Nutr. | pmid:8310987 |
Doering TL et al. | The fatty acids in unremodelled trypanosome glycosyl-phosphatidylinositols. | 1994 | Biochem. J. | pmid:8192662 |
Lee WN et al. | In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. | 1994 | Am. J. Physiol. | pmid:8203508 |
Hyson DA et al. | Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits. | 1994 | Lipids | pmid:8177021 |
Poisson JP | Lipid metabolism. | 1995 | Curr. Opin. Lipidol. | pmid:7670747 |
Bruce JS et al. | Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes. | 1995 | Biochem. Soc. Trans. | pmid:7672331 |
Zeng FY et al. | Fatty acylation of the rat asialoglycoprotein receptor. The three subunits from active receptors contain covalently bound palmitate and stearate. | 1995 | J. Biol. Chem. | pmid:7673174 |
Blechert S et al. | The octadecanoic pathway: signal molecules for the regulation of secondary pathways. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7753776 |
Morrow MR et al. | Glycosphingolipid acyl chain order profiles: substituent effects. | 1995 | Biochim. Biophys. Acta | pmid:7756331 |
Dougherty RM et al. | Effects of diets containing high or low amounts of stearic acid on plasma lipoprotein fractions and fecal fatty acid excretion of men. | 1995 | Am. J. Clin. Nutr. | pmid:7733038 |
Yu S et al. | Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. | 1995 | Am. J. Clin. Nutr. | pmid:7733039 |
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