stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Cisar LA et al. Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. 1993 Cell. Signal. pmid:8373725
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Chigorno V et al. Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. 1994 Eur. J. Biochem. pmid:8181467
Croxtall JD et al. Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. 1994 Biochem. Pharmacol. pmid:8304964
Mitropoulos KA et al. Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. 1994 Arterioscler. Thromb. pmid:8305411
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Ikeda I et al. Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. 1994 J. Nutr. Sci. Vitaminol. pmid:7965216
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Catalá A et al. Interaction of rat liver microsomes containing saturated or unsaturated fatty acids with fatty acid binding protein: peroxidation effect. 1994 Mol. Cell. Biochem. pmid:7845387
Lu B et al. Characterization of modified staphylococcal protein A containing phospholipid monolayer on both solution and slide surfaces. 1994 Biochem. Biophys. Res. Commun. pmid:8185601
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Batten TL et al. Contact dermatitis from the old formula E45 cream. 1994 Contact Derm. pmid:8187515
Rabinowitz JL and Myerson RM Changes in the lipid content of rat lymph after the ingestion of [14C] long-chain fatty acids. 1994 Life Sci. pmid:8107533
Lee WN et al. Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. 1994 Am. J. Physiol. pmid:8166257
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Shenai JP and Chytil F Effect of maternal dexamethasone treatment on fetal lung vitamin A stores in the perinatal rat. 1994 Int J Vitam Nutr Res pmid:7960497
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Ellingson JS and Seenaiah B The selective use of stearoyl-polyunsaturated molecular species of phosphatidylcholine and phosphatidylethanolamine for the synthesis of phosphatidylserine. 1994 Biochim. Biophys. Acta pmid:8011673
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Fuller CJ and Jialal I Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. 1994 Am. J. Clin. Nutr. pmid:7977141
Denke MA Effects of cocoa butter on serum lipids in humans: historical highlights. 1994 Am. J. Clin. Nutr. pmid:7977142
Emken EA Metabolism of dietary stearic acid relative to other fatty acids in human subjects. 1994 Am. J. Clin. Nutr. pmid:7977144
Kris-Etherton PM and Mustad VA Chocolate feeding studies: a novel approach for evaluating the plasma lipid effects of stearic acid. 1994 Am. J. Clin. Nutr. pmid:7977145
Dougherty RM et al. Total and low-density-lipoprotein cholesterol lipoprotein fractions and fecal fatty acid excretion of men consuming diets containing high concentrations of stearic acid. 1994 Am. J. Clin. Nutr. pmid:7977147
Denke MA Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet. 1994 Am. J. Clin. Nutr. pmid:7977148
Hoak JC Stearic acid, clotting, and thrombosis. 1994 Am. J. Clin. Nutr. pmid:7977149
Blair IA et al. Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. 1994 Am. J. Clin. Nutr. pmid:7977150
Schoene NW et al. Dissimilar responses of platelets to dietary stearic and palmitic acids. 1994 Am. J. Clin. Nutr. pmid:7977151
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Vanderveen JE Regulatory history for stearic acid. 1994 Am. J. Clin. Nutr. pmid:7977156
Kritchevsky D Stearic acid metabolism and atherogenesis: history. 1994 Am. J. Clin. Nutr. pmid:7977159
Taylor AJ Erythrocyte membrane fatty acid composition in hypercholesterolaemia. 1994 Ann. Clin. Biochem. pmid:7979101
Grundy SM Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. 1994 Am. J. Clin. Nutr. pmid:7977157
Redgrave TG et al. The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. 1994 Biochim. Biophys. Acta pmid:8117751
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Golovina EA and Tikhonov AN The structural differences between the embryos of viable and nonviable wheat seeds as studied with the EPR spectroscopy of lipid-soluble spin labels. 1994 Biochim. Biophys. Acta pmid:8142440
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Wonsil BJ et al. Dietary and ruminally derived trans-18:1 fatty acids alter bovine milk lipids. 1994 J. Nutr. pmid:8145078
Tholstrup T et al. Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. 1994 Am. J. Clin. Nutr. pmid:8310987
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