stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Ahmad SN et al. Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. 1990 Arch. Oral Biol. pmid:2281999
Rawat MK et al. Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. 2010 Ther Deliv pmid:22816120
Dawes J et al. Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations. 2013 Pharm Dev Technol pmid:22813432
Tamokou Jde D et al. Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). 2012 BMC Complement Altern Med pmid:22809287
Trupp M et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. 2012 PLoS ONE pmid:22808006
El Semary NA The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. 2012 World J. Microbiol. Biotechnol. pmid:22806854
Xie YT et al. Brain-targeting study of stearic acid-grafted chitosan micelle drug-delivery system. 2012 Int J Nanomedicine pmid:22802685
Han K et al. Novel gene transfer vectors based on artificial recombinant multi-functional oligopeptides. 2012 Int J Pharm pmid:22796172
Horio T et al. Measurement of flowability of lubricated powders by the vibrating tube method. 2013 Drug Dev Ind Pharm pmid:22781029
Jubie S et al. Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. 2012 Eur J Med Chem pmid:22770606
Irvine RF et al. The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. 1979 Eur. J. Biochem. pmid:227685
Busignies V et al. Prediction of the compressibility of complex mixtures of pharmaceutical powders. 2012 Int J Pharm pmid:22759643
Kottala N et al. Influence of compaction properties and interfacial topography on the performance of bilayer tablets. 2012 Int J Pharm pmid:22728259
Kwan HY et al. The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. 2013 J. Gastroenterol. pmid:22722903
Sekharan TR et al. Formulation and Evaluation of Hydroxypropyl Methylcellulose-based Controlled Release Matrix Tablets for Theophylline. 2011 Indian J Pharm Sci pmid:22707833
Nagarsekar KS et al. Antioxidant and antilipid peroxidation potential of supercritical fluid extract and ethanol extract of leaves of vitex negundo linn. 2011 Indian J Pharm Sci pmid:22707827
Masareddy R et al. Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient Bases. 2011 Indian J Pharm Sci pmid:22707822
Sampey BP et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. 2012 PLoS ONE pmid:22701716
Smathers RL et al. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. 2012 PLoS ONE pmid:22701647
Wang L et al. Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides. 2012 PLoS ONE pmid:22693627
Griffith EC et al. Hydrophobic collapse of a stearic acid film by adsorbed l-phenylalanine at the air-water interface. 2012 J Phys Chem B pmid:22691061
Wong RH et al. Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. 2012 Nutrients pmid:22690320
Rojas J and Kumar V Effect of silicification on the tableting performance of cellulose ii: a novel multifunctional excipient. 2012 Chem. Pharm. Bull. pmid:22689398
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Bederman I et al. Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22679004
Göker M et al. Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSA(T)) from a deep-sea hydrothermal vent. 2011 Stand Genomic Sci pmid:22675590
Rozema E et al. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. 2012 Evid Based Complement Alternat Med pmid:22675394
Bevilacqua A et al. Selection of Yeasts as Starter Cultures for Table Olives: A Step-by-Step Procedure. 2012 Front Microbiol pmid:22666220
Zhang WY et al. Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats. 2012 J Pharm Biomed Anal pmid:22658902
Mekhail GM et al. Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan. 2012 Int. J. Biol. Macromol. pmid:22652220
Watanabe H et al. Biosynthetic Pathway for Sex Pheromone Components Produced in a Plusiinae Moth, Plusia festucae. 2011 Front Endocrinol (Lausanne) pmid:22649385
Shah KU and Khan GM Regulating drug release behavior and kinetics from matrix tablets based on fine particle-sized ethyl cellulose ether derivatives: an in vitro and in vivo evaluation. 2012 ScientificWorldJournal pmid:22649325
Masuda M et al. Activating transcription factor 4 regulates stearate-induced vascular calcification. 2012 J. Lipid Res. pmid:22628618
Yavuz B et al. An overview on dry eye treatment: approaches for cyclosporin a delivery. 2012 ScientificWorldJournal pmid:22619624
Rowe RC The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. 1977 J. Pharm. Pharmacol. pmid:22617
Shivanand K et al. In vivo bioavailability studies of sumatriptan succinate buccal tablets. 2011 Daru pmid:22615661
Gande S and Rao Y Sustained-release effervescent floating matrix tablets of baclofen: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. 2011 Daru pmid:22615658
Varshosaz J et al. Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats. 2011 Daru pmid:22615647
Nokhodchi A et al. Physico-mechanical and dissolution behaviours of ibuprofen crystals crystallized in the presence of various additives. 2010 Daru pmid:22615598
Guillon A et al. Pulmonary delivery of dry powders to rats: tolerability limits of an intra-tracheal administration model. 2012 Int J Pharm pmid:22609125
Agostini F et al. Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. 2012 ScientificWorldJournal pmid:22593706
Polizzotti BD et al. Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. 2012 PLoS ONE pmid:22590609
Song IS et al. Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. 2012 PLoS ONE pmid:22590580
Ahmed TA et al. Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. 2012 AAPS PharmSciTech pmid:22585373
Tuli RA et al. Studies on the effect of the size of polycaprolactone microspheres for the dispersion of salbutamol sulfate from dry powder inhaler formulations. 2012 Pharm. Res. pmid:22584947
Varshosaz J et al. Development and evaluation of a novel pellet-based tablet system for potential colon delivery of budesonide. 2012 J Drug Deliv pmid:22577558
Chakradhar RP and Dinesh Kumar V Water-repellent coatings prepared by modification of ZnO nanoparticles. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22575349
Stinton LM and Shaffer EA Epidemiology of gallbladder disease: cholelithiasis and cancer. 2012 Gut Liver pmid:22570746
Vinay KB et al. Spectrophotometric Determination of Mycophenolate Mofetil as Its Charge-Transfer Complexes with Two π-Acceptors. 2012 J Anal Methods Chem pmid:22567572
Prashanth KN and Basavaiah K Sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent. 2012 J Anal Methods Chem pmid:22567567
de Souza Monteiro A et al. Bioconversion of biodiesel refinery waste in the bioemulsifier by Trichosporon mycotoxinivorans CLA2. 2012 Biotechnol Biofuels pmid:22559210
Anderson EK et al. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22556332
Loutelier-Bourhis C et al. Mechanistic study of maleic anhydride grafting onto fatty double bonds using mass spectrometry. 2012 Rapid Commun. Mass Spectrom. pmid:22555920
Schrank S et al. Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. 2012 AAPS PharmSciTech pmid:22552931
Itoh Y and Hasegawa T Polarization dependence of Raman scattering from a thin film involving optical anisotropy theorized for molecular orientation analysis. 2012 J Phys Chem A pmid:22551093
Lalloo AK et al. Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model. 2012 Int J Pharm pmid:22546295
Schaab M et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. 2012 PLoS ONE pmid:22545089
Islam A and Ehsan A Comparison of suture material and technique of closure of subcutaneous fat and skin in caesarean section. 2011 N Am J Med Sci pmid:22540072
Yang P et al. Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. 2012 PLoS ONE pmid:22536429
Meka VS et al. Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. 2012 Invest Clin pmid:22524109
Guo C et al. In vitro evaluation and finite element simulation of drug release from polydiacetylene-polyethylene glycol stearate nanovesicles. 2012 J Nanosci Nanotechnol pmid:22523972
Nagpal M et al. Formulation development and evaluation of alginate microspheres of Ibuprofen. 2012 J Young Pharm pmid:22523454
Vijay J et al. Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. 2012 J Young Pharm pmid:22523453
Baratta F et al. Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity. 2012 Croat. Med. J. pmid:22522996
Taveira SF et al. Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin. 2012 J Biomed Nanotechnol pmid:22515073
Chen M et al. [Study on the chemical constituents from Fructus Toosendan (III)]. 2011 Zhong Yao Cai pmid:22500422
UÄŸurlu T et al. Effects of lubricants on binary direct compression mixtures. 2010 Drug Discov Ther pmid:22491169
Kwon Y et al. Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. 2012 Int J Mol Sci pmid:22489147
Krogager TP et al. Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1). 2012 J Proteomics pmid:22483997
Toubiana D et al. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. 2012 PLoS Genet. pmid:22479206
Arya A et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. 2012 Evid Based Complement Alternat Med pmid:22474512
Varshosaz J et al. Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. 2012 Acta Pharm pmid:22472447
Zhu S et al. Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. 2012 Bioconjug. Chem. pmid:22471294
Milicic A et al. Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. 2012 PLoS ONE pmid:22470545
Pawar AA et al. Influence of precursor solvent properties on matrix crystallinity and drug release rates from nanoparticle aerosol lipid matrices. 2012 Int J Pharm pmid:22469694
Gröblacher B et al. Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. 2012 Bioorg. Med. Chem. pmid:22459211
Wajid NA and Halpern BP Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. 2012 Chem. Senses pmid:22459162
Mason P et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. 2012 PLoS ONE pmid:22457791
Olivieri C et al. Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. 2012 PLoS ONE pmid:22457789
Haghjou N et al. Sustained release intraocular drug delivery devices for treatment of uveitis. 2011 J Ophthalmic Vis Res pmid:22454753
Ménard N et al. Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. 2012 Pharm. Res. pmid:22451248
Nakagawa H et al. Evaluation of infrared-reflection absorption spectroscopy measurement and locally weighted partial least-squares for rapid analysis of residual drug substances in cleaning processes. 2012 Anal. Chem. pmid:22449097
McIlhinney RA and McGlone K Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. 1990 Biochem. J. pmid:2244873
John Wallace R Gut microbiology - broad genetic diversity, yet specific metabolic niches. 2008 Animal pmid:22443591
Imarisio C et al. Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. 2012 Clin. Sci. pmid:22439844
Baldwin AC et al. A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22436701
Chansela P et al. Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. 2012 PLoS ONE pmid:22432001
Kelly SB et al. Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. 1990 Dis. Colon Rectum pmid:2242696
Trinchera M et al. Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. 1990 Biochem. J. pmid:2241913
Lipasek RA et al. Effects of anticaking agents and relative humidity on the physical and chemical stability of powdered vitamin C. 2011 J. Food Sci. pmid:22417544
Liu D et al. Synthesis and characterization of upconverting NaYF4:Er3+, Yb3+ nanocrystals via thermal decomposition of stearate precursor. 2011 J Nanosci Nanotechnol pmid:22413291
Matsui H et al. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. 2012 PLoS ONE pmid:22413010
Liu X et al. Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. 2012 PLoS Pathog. pmid:22412372
García MS et al. Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine. 2009 Sensors (Basel) pmid:22408528
Kushner J Incorporating Turbula mixers into a blending scale-up model for evaluating the effect of magnesium stearate on tablet tensile strength and bulk specific volume. 2012 Int J Pharm pmid:22405966
Lee AL and Kim CB The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients. 2012 J Korean Surg Soc pmid:22403748
Khan FN and Dehghan MH Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives. 2012 Jan-Mar Sci Pharm pmid:22396916
Pujeri SS et al. Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method. 2012 Jan-Mar Sci Pharm pmid:22396908
Watanabe Y et al. The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. 2012 Diabetes pmid:22396206
Feugmo CG et al. Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces. 2012 J Phys Condens Matter pmid:22394578