stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ahmad SN et al. | Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. | 1990 | Arch. Oral Biol. | pmid:2281999 |
Rawat MK et al. | Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. | 2010 | Ther Deliv | pmid:22816120 |
Dawes J et al. | Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations. | 2013 | Pharm Dev Technol | pmid:22813432 |
Tamokou Jde D et al. | Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). | 2012 | BMC Complement Altern Med | pmid:22809287 |
Trupp M et al. | Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. | 2012 | PLoS ONE | pmid:22808006 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
Xie YT et al. | Brain-targeting study of stearic acid-grafted chitosan micelle drug-delivery system. | 2012 | Int J Nanomedicine | pmid:22802685 |
Han K et al. | Novel gene transfer vectors based on artificial recombinant multi-functional oligopeptides. | 2012 | Int J Pharm | pmid:22796172 |
Horio T et al. | Measurement of flowability of lubricated powders by the vibrating tube method. | 2013 | Drug Dev Ind Pharm | pmid:22781029 |
Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
Irvine RF et al. | The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. | 1979 | Eur. J. Biochem. | pmid:227685 |
Busignies V et al. | Prediction of the compressibility of complex mixtures of pharmaceutical powders. | 2012 | Int J Pharm | pmid:22759643 |
Kottala N et al. | Influence of compaction properties and interfacial topography on the performance of bilayer tablets. | 2012 | Int J Pharm | pmid:22728259 |
Kwan HY et al. | The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. | 2013 | J. Gastroenterol. | pmid:22722903 |
Sekharan TR et al. | Formulation and Evaluation of Hydroxypropyl Methylcellulose-based Controlled Release Matrix Tablets for Theophylline. | 2011 | Indian J Pharm Sci | pmid:22707833 |
Nagarsekar KS et al. | Antioxidant and antilipid peroxidation potential of supercritical fluid extract and ethanol extract of leaves of vitex negundo linn. | 2011 | Indian J Pharm Sci | pmid:22707827 |
Masareddy R et al. | Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient Bases. | 2011 | Indian J Pharm Sci | pmid:22707822 |
Sampey BP et al. | Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. | 2012 | PLoS ONE | pmid:22701716 |
Smathers RL et al. | Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | 2012 | PLoS ONE | pmid:22701647 |
Wang L et al. | Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides. | 2012 | PLoS ONE | pmid:22693627 |
Griffith EC et al. | Hydrophobic collapse of a stearic acid film by adsorbed l-phenylalanine at the air-water interface. | 2012 | J Phys Chem B | pmid:22691061 |
Wong RH et al. | Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. | 2012 | Nutrients | pmid:22690320 |
Rojas J and Kumar V | Effect of silicification on the tableting performance of cellulose ii: a novel multifunctional excipient. | 2012 | Chem. Pharm. Bull. | pmid:22689398 |
Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
Bederman I et al. | Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22679004 |
Göker M et al. | Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSA(T)) from a deep-sea hydrothermal vent. | 2011 | Stand Genomic Sci | pmid:22675590 |
Rozema E et al. | Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22675394 |
Bevilacqua A et al. | Selection of Yeasts as Starter Cultures for Table Olives: A Step-by-Step Procedure. | 2012 | Front Microbiol | pmid:22666220 |
Zhang WY et al. | Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats. | 2012 | J Pharm Biomed Anal | pmid:22658902 |
Mekhail GM et al. | Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan. | 2012 | Int. J. Biol. Macromol. | pmid:22652220 |
Watanabe H et al. | Biosynthetic Pathway for Sex Pheromone Components Produced in a Plusiinae Moth, Plusia festucae. | 2011 | Front Endocrinol (Lausanne) | pmid:22649385 |
Shah KU and Khan GM | Regulating drug release behavior and kinetics from matrix tablets based on fine particle-sized ethyl cellulose ether derivatives: an in vitro and in vivo evaluation. | 2012 | ScientificWorldJournal | pmid:22649325 |
Masuda M et al. | Activating transcription factor 4 regulates stearate-induced vascular calcification. | 2012 | J. Lipid Res. | pmid:22628618 |
Yavuz B et al. | An overview on dry eye treatment: approaches for cyclosporin a delivery. | 2012 | ScientificWorldJournal | pmid:22619624 |
Rowe RC | The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. | 1977 | J. Pharm. Pharmacol. | pmid:22617 |
Shivanand K et al. | In vivo bioavailability studies of sumatriptan succinate buccal tablets. | 2011 | Daru | pmid:22615661 |
Gande S and Rao Y | Sustained-release effervescent floating matrix tablets of baclofen: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. | 2011 | Daru | pmid:22615658 |
Varshosaz J et al. | Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats. | 2011 | Daru | pmid:22615647 |
Nokhodchi A et al. | Physico-mechanical and dissolution behaviours of ibuprofen crystals crystallized in the presence of various additives. | 2010 | Daru | pmid:22615598 |
Guillon A et al. | Pulmonary delivery of dry powders to rats: tolerability limits of an intra-tracheal administration model. | 2012 | Int J Pharm | pmid:22609125 |
Agostini F et al. | Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. | 2012 | ScientificWorldJournal | pmid:22593706 |
Polizzotti BD et al. | Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. | 2012 | PLoS ONE | pmid:22590609 |
Song IS et al. | Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. | 2012 | PLoS ONE | pmid:22590580 |
Ahmed TA et al. | Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. | 2012 | AAPS PharmSciTech | pmid:22585373 |
Tuli RA et al. | Studies on the effect of the size of polycaprolactone microspheres for the dispersion of salbutamol sulfate from dry powder inhaler formulations. | 2012 | Pharm. Res. | pmid:22584947 |
Varshosaz J et al. | Development and evaluation of a novel pellet-based tablet system for potential colon delivery of budesonide. | 2012 | J Drug Deliv | pmid:22577558 |
Chakradhar RP and Dinesh Kumar V | Water-repellent coatings prepared by modification of ZnO nanoparticles. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22575349 |
Stinton LM and Shaffer EA | Epidemiology of gallbladder disease: cholelithiasis and cancer. | 2012 | Gut Liver | pmid:22570746 |
Vinay KB et al. | Spectrophotometric Determination of Mycophenolate Mofetil as Its Charge-Transfer Complexes with Two π-Acceptors. | 2012 | J Anal Methods Chem | pmid:22567572 |
Prashanth KN and Basavaiah K | Sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent. | 2012 | J Anal Methods Chem | pmid:22567567 |
de Souza Monteiro A et al. | Bioconversion of biodiesel refinery waste in the bioemulsifier by Trichosporon mycotoxinivorans CLA2. | 2012 | Biotechnol Biofuels | pmid:22559210 |
Anderson EK et al. | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22556332 |
Loutelier-Bourhis C et al. | Mechanistic study of maleic anhydride grafting onto fatty double bonds using mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22555920 |
Schrank S et al. | Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. | 2012 | AAPS PharmSciTech | pmid:22552931 |
Itoh Y and Hasegawa T | Polarization dependence of Raman scattering from a thin film involving optical anisotropy theorized for molecular orientation analysis. | 2012 | J Phys Chem A | pmid:22551093 |
Lalloo AK et al. | Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model. | 2012 | Int J Pharm | pmid:22546295 |
Schaab M et al. | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. | 2012 | PLoS ONE | pmid:22545089 |
Islam A and Ehsan A | Comparison of suture material and technique of closure of subcutaneous fat and skin in caesarean section. | 2011 | N Am J Med Sci | pmid:22540072 |
Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
Meka VS et al. | Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. | 2012 | Invest Clin | pmid:22524109 |
Guo C et al. | In vitro evaluation and finite element simulation of drug release from polydiacetylene-polyethylene glycol stearate nanovesicles. | 2012 | J Nanosci Nanotechnol | pmid:22523972 |
Nagpal M et al. | Formulation development and evaluation of alginate microspheres of Ibuprofen. | 2012 | J Young Pharm | pmid:22523454 |
Vijay J et al. | Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. | 2012 | J Young Pharm | pmid:22523453 |
Baratta F et al. | Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity. | 2012 | Croat. Med. J. | pmid:22522996 |
Taveira SF et al. | Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin. | 2012 | J Biomed Nanotechnol | pmid:22515073 |
Chen M et al. | [Study on the chemical constituents from Fructus Toosendan (III)]. | 2011 | Zhong Yao Cai | pmid:22500422 |
UÄŸurlu T et al. | Effects of lubricants on binary direct compression mixtures. | 2010 | Drug Discov Ther | pmid:22491169 |
Kwon Y et al. | Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. | 2012 | Int J Mol Sci | pmid:22489147 |
Krogager TP et al. | Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1). | 2012 | J Proteomics | pmid:22483997 |
Toubiana D et al. | Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. | 2012 | PLoS Genet. | pmid:22479206 |
Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
Varshosaz J et al. | Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. | 2012 | Acta Pharm | pmid:22472447 |
Zhu S et al. | Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. | 2012 | Bioconjug. Chem. | pmid:22471294 |
Milicic A et al. | Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. | 2012 | PLoS ONE | pmid:22470545 |
Pawar AA et al. | Influence of precursor solvent properties on matrix crystallinity and drug release rates from nanoparticle aerosol lipid matrices. | 2012 | Int J Pharm | pmid:22469694 |
Gröblacher B et al. | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. | 2012 | Bioorg. Med. Chem. | pmid:22459211 |
Wajid NA and Halpern BP | Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. | 2012 | Chem. Senses | pmid:22459162 |
Mason P et al. | SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. | 2012 | PLoS ONE | pmid:22457791 |
Olivieri C et al. | Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. | 2012 | PLoS ONE | pmid:22457789 |
Haghjou N et al. | Sustained release intraocular drug delivery devices for treatment of uveitis. | 2011 | J Ophthalmic Vis Res | pmid:22454753 |
Ménard N et al. | Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. | 2012 | Pharm. Res. | pmid:22451248 |
Nakagawa H et al. | Evaluation of infrared-reflection absorption spectroscopy measurement and locally weighted partial least-squares for rapid analysis of residual drug substances in cleaning processes. | 2012 | Anal. Chem. | pmid:22449097 |
McIlhinney RA and McGlone K | Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. | 1990 | Biochem. J. | pmid:2244873 |
John Wallace R | Gut microbiology - broad genetic diversity, yet specific metabolic niches. | 2008 | Animal | pmid:22443591 |
Imarisio C et al. | Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. | 2012 | Clin. Sci. | pmid:22439844 |
Baldwin AC et al. | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22436701 |
Chansela P et al. | Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. | 2012 | PLoS ONE | pmid:22432001 |
Kelly SB et al. | Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. | 1990 | Dis. Colon Rectum | pmid:2242696 |
Trinchera M et al. | Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. | 1990 | Biochem. J. | pmid:2241913 |
Lipasek RA et al. | Effects of anticaking agents and relative humidity on the physical and chemical stability of powdered vitamin C. | 2011 | J. Food Sci. | pmid:22417544 |
Liu D et al. | Synthesis and characterization of upconverting NaYF4:Er3+, Yb3+ nanocrystals via thermal decomposition of stearate precursor. | 2011 | J Nanosci Nanotechnol | pmid:22413291 |
Matsui H et al. | Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. | 2012 | PLoS ONE | pmid:22413010 |
Liu X et al. | Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. | 2012 | PLoS Pathog. | pmid:22412372 |
GarcÃa MS et al. | Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine. | 2009 | Sensors (Basel) | pmid:22408528 |
Kushner J | Incorporating Turbula mixers into a blending scale-up model for evaluating the effect of magnesium stearate on tablet tensile strength and bulk specific volume. | 2012 | Int J Pharm | pmid:22405966 |
Lee AL and Kim CB | The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients. | 2012 | J Korean Surg Soc | pmid:22403748 |
Khan FN and Dehghan MH | Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives. | 2012 Jan-Mar | Sci Pharm | pmid:22396916 |
Pujeri SS et al. | Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method. | 2012 Jan-Mar | Sci Pharm | pmid:22396908 |
Watanabe Y et al. | The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. | 2012 | Diabetes | pmid:22396206 |
Feugmo CG et al. | Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces. | 2012 | J Phys Condens Matter | pmid:22394578 |