stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fodorová M et al. | Structural features of lipid A of Rickettsia typhi. | 2011 | Acta Virol. | pmid:21434703 |
Ropero J et al. | Near-infrared chemical imaging slope as a new method to study tablet compaction and tablet relaxation. | 2011 | Appl Spectrosc | pmid:21396195 |
Junk MJ et al. | DEER in biological multispin-systems: a case study on the fatty acid binding to human serum albumin. | 2011 | J. Magn. Reson. | pmid:21450500 |
Franch-Lage F et al. | Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging. | 2011 | Int J Pharm | pmid:21419207 |
de Lima-Salgado TM et al. | Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. | 2011 | Cell Biochem. Biophys. | pmid:20809180 |
James J et al. | Two-dimensional surface properties of PEO-PPO-PEO triblock copolymer film at the air/water interface in the absence and presence of Tyr-Phe dipeptide, Val-Tyr-Val tripeptide, SDS and stearic acid. | 2011 | Colloids Surf B Biointerfaces | pmid:20888193 |
Park MY et al. | Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice. | 2011 | Nutr Res Pract | pmid:22259675 |
Basu B et al. | Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material. | 2011 | J Adv Pharm Technol Res | pmid:22247895 |
Ely DR and Carvajal MT | Determination of the scale of segregation of low dose tablets using hyperspectral imaging. | 2011 | Int J Pharm | pmid:21601625 |
Neji SB et al. | Esterification of fatty acid over Tunisian acid activated clay: kinetic study. | 2011 | J Oleo Sci | pmid:21606617 |
Whitney TR et al. | Redberry juniper as a roughage source in lamb feedlot rations: wool and carcass characteristics, meat fatty acid profiles, and sensory panel traits. | 2011 | Meat Sci. | pmid:21570776 |
Yalcin H et al. | Effect of gamma-irradiation on some chemical characteristics and volatile content of linseed. | 2011 | J Med Food | pmid:21548804 |
Lavigne JP et al. | Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. | 2011 | BMC Res Notes | pmid:22126300 |
Steidl S et al. | Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. | 2011 | PLoS ONE | pmid:22102904 |
Meissner M et al. | Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. | 2011 | PLoS ONE | pmid:22087215 |
Guschina I et al. | Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. | 2011 | Lipids | pmid:20963507 |
Bailey JA et al. | Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. | 2011 | PLoS ONE | pmid:21799757 |
Protière M et al. | Rational design of the gram-scale synthesis of nearly monodisperse semiconductor nanocrystals. | 2011 | Nanoscale Res Lett | pmid:21791060 |
Rajendraprasad N et al. | Titrimetric and spectrophotometric assay of oxcarbazepine in pharmaceuticals using N-bromosuccinimide and bromopyrogallol red. | 2011 | Int J Anal Chem | pmid:21785594 |
Bhope SG et al. | Design and development of a stable polyherbal formulation based on the results of compatibility studies. | 2011 | Pharmacognosy Res | pmid:21772756 |
Williams KJ et al. | The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. | 2011 | Tuberculosis (Edinb) | pmid:21764638 |
Zhang H et al. | Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. | 2011 | Evid Based Complement Alternat Med | pmid:21760826 |
Raza A and Zia-Ul-Haq M | Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms. | 2011 | Int J Anal Chem | pmid:21760789 |
Chabukswar A et al. | Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet. | 2011 | J Young Pharm | pmid:21607050 |
Lacaze C et al. | The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. | 2011 | Malar. J. | pmid:21605361 |
Houmard JA et al. | Is there a metabolic program in the skeletal muscle of obese individuals? | 2011 | J Obes | pmid:21603262 |
Li C et al. | Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. | 2011 | Carcinogenesis | pmid:21586513 |
Mahdi ES et al. | Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. | 2011 | Drug Des Devel Ther | pmid:21792294 |
Santos GM et al. | Negative regulation by nuclear receptors: a plethora of mechanisms. | 2011 | Trends Endocrinol. Metab. | pmid:21196123 |
Han L et al. | Starch stearate as a novel encapsulation wall material and its effect on oil-water interfacial tension. | 2011 | J Control Release | pmid:22195872 |
Dasu MR and Jialal I | Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:20959532 |
Goto T et al. | Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | 2011 | Biochem. J. | pmid:21605082 |
Kasliwal N et al. | Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. | 2011 | Arch. Pharm. Res. | pmid:22076769 |
Kushner J et al. | Examining the impact of excipient material property variation on drug product quality attributes: a quality-by-design study for a roller compacted, immediate release tablet. | 2011 | J Pharm Sci | pmid:21319161 |
de Sousa Neto D et al. | Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I). | 2011 | Chem. Phys. Lipids | pmid:21238439 |
Seow LJ et al. | Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. | 2011 | J Ethnopharmacol | pmid:21167271 |
Price ER et al. | Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21153644 |
Liu H et al. | A surfactant-free recipe for shape-controlled synthesis of CdSe nanocrystals. | 2011 | Nanotechnology | pmid:21169661 |
Aardema H et al. | Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. | 2011 | Biol. Reprod. | pmid:21311036 |
Pingali K et al. | Mixing order of glidant and lubricant--influence on powder and tablet properties. | 2011 | Int J Pharm | pmid:21356286 |
Zaki Rizkalla CM et al. | In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. | 2011 | AAPS PharmSciTech | pmid:21800216 |
Roblegg E et al. | Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. | 2011 | Eur J Pharm Biopharm | pmid:21801834 |
Van Hoeck V et al. | Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. | 2011 | PLoS ONE | pmid:21858021 |
El Andaloussi S et al. | Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21748634 |
de Morais e Silva FA et al. | Rosacea fulminans in pregnancy with ocular perforation. | 2011 | J Dtsch Dermatol Ges | pmid:21366860 |
Morinaga N et al. | Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. | 2011 | Enzyme Microb. Technol. | pmid:22113022 |
Perrault M et al. | An experimental investigation of the effect of the amount of lubricant on tablet properties. | 2011 | Drug Dev Ind Pharm | pmid:20704461 |
Cheng YY et al. | A novel cold-adapted lipase from Sorangium cellulosum strain So0157-2: gene cloning, expression, and enzymatic characterization. | 2011 | Int J Mol Sci | pmid:22072918 |
Lee YJ and Jenkins TC | Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. | 2011 | J. Nutr. | pmid:21653571 |
Sloat BR et al. | In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles. | 2011 | Int J Pharm | pmid:21371545 |