stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
de Souza Monteiro A et al. Bioconversion of biodiesel refinery waste in the bioemulsifier by Trichosporon mycotoxinivorans CLA2. 2012 Biotechnol Biofuels pmid:22559210
Zanon NC et al. Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. 2012 J Colloid Interface Sci pmid:21875709
Kim S et al. Lipid-binding properties of TRIM72. 2012 BMB Rep pmid:22281009
Hao J et al. Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. 2012 Eur J Pharm Sci pmid:22820033
Simmons DM and Gierer DS A material sparing test to predict punch sticking during formulation development. 2012 Drug Dev Ind Pharm pmid:22181042
Xie J et al. Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. 2012 Nat. Prod. Res. pmid:21707231
Brown PN et al. Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. 2011 Sep-Oct J AOAC Int pmid:22165004
Tomuta I et al. High-Throughput NIR-Chemometric Method for Meloxicam Assay from Powder Blends for Tableting. 2011 Oct-Dec Sci Pharm pmid:22145112
Nanjwade BK et al. Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs. 2011 Oct-Dec Sci Pharm pmid:22145101
Jelvehgari M et al. Formulation, characterization and in vitro evaluation of theophylline-loaded Eudragit RS 100 microspheres prepared by an emulsion-solvent diffusion/evaporation technique. 2011 Nov-Dec Pharm Dev Technol pmid:20722498
Qu WX et al. Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. 2011 May-Jun Phytochem Anal pmid:20848395
Nath B et al. Preparation and in vitro dissolution profile of zidovudine loaded microspheres made of Eudragit RS 100, RL 100 and their combinations. 2011 May-Jun Acta Pol Pharm pmid:21648196
BozdaÄŸ-Pehlivan S et al. Evaluation of drug-excipient interaction in the formulation of celecoxib tablets. 2011 May-Jun Acta Pol Pharm pmid:21648198
Malik K et al. Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets. 2011 Jul-Sep Sci Pharm pmid:21886910
Zaid AN et al. Formulation and bioequivalence of two valsartan tablets after a single oral administration. 2011 Jan-Mar Sci Pharm pmid:21617777
Shah DA et al. Stability indicating LC-method for estimation of paracetamol and lornoxicam in combined dosage form. 2011 Jan-Mar Sci Pharm pmid:21617776
Liu Z et al. [Chemical constituents from root bark of Tripterygium hypoglaucum]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22256754
Uchino T et al. Effects of coating materials and size of titanium dioxide particles on their cytotoxicity and penetration into the cellular membrane. 2011 J Toxicol Sci pmid:21297346
Shin S et al. Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles. 2011 Int J Pharm pmid:21251963
Calegari VC et al. Inflammation of the hypothalamus leads to defective pancreatic islet function. 2011 J. Biol. Chem. pmid:21257748
Uchimoto T et al. A comparative study of glycerin fatty acid ester and magnesium stearate on the dissolution of acetaminophen tablets using the analysis of available surface area. 2011 Eur J Pharm Biopharm pmid:21284955
Subczynski WK et al. Spin-label oximetry at Q- and W-band. 2011 J. Magn. Reson. pmid:21277814
Potta SG et al. Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. 2011 J Microencapsul pmid:21171818
Mosca M et al. Effect of membrane composition on lipid oxidation in liposomes. 2011 Chem. Phys. Lipids pmid:21185813
de Lima-Salgado TM et al. Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. 2011 Cell Biochem. Biophys. pmid:20809180
James J et al. Two-dimensional surface properties of PEO-PPO-PEO triblock copolymer film at the air/water interface in the absence and presence of Tyr-Phe dipeptide, Val-Tyr-Val tripeptide, SDS and stearic acid. 2011 Colloids Surf B Biointerfaces pmid:20888193
Park MY et al. Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice. 2011 Nutr Res Pract pmid:22259675
Basu B et al. Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material. 2011 J Adv Pharm Technol Res pmid:22247895
Zhang Y and Clapp A Overview of stabilizing ligands for biocompatible quantum dot nanocrystals. 2011 Sensors (Basel) pmid:22247651
Jishnu V et al. Formulation and evaluation of cephalexin extended release matrix tablets using 3 factorial design. 2011 J Young Pharm pmid:22224031
Chen M et al. [Study on the chemical constituents from Fructus Toosendan (III)]. 2011 Zhong Yao Cai pmid:22500422
Steidl S et al. Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. 2011 PLoS ONE pmid:22102904
Meissner M et al. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. 2011 PLoS ONE pmid:22087215
Wu DJ et al. Metabonomics-based omics study and atherosclerosis. 2011 J Clin Bioinforma pmid:22040517
Guschina I et al. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. 2011 Lipids pmid:20963507
Walash MI et al. Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids. 2011 Chem Cent J pmid:21996025
Protière M et al. Rational design of the gram-scale synthesis of nearly monodisperse semiconductor nanocrystals. 2011 Nanoscale Res Lett pmid:21791060
Rajendraprasad N et al. Titrimetric and spectrophotometric assay of oxcarbazepine in pharmaceuticals using N-bromosuccinimide and bromopyrogallol red. 2011 Int J Anal Chem pmid:21785594
Bhope SG et al. Design and development of a stable polyherbal formulation based on the results of compatibility studies. 2011 Pharmacognosy Res pmid:21772756
Williams KJ et al. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. 2011 Tuberculosis (Edinb) pmid:21764638
Zhang H et al. Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. 2011 Evid Based Complement Alternat Med pmid:21760826
Raza A and Zia-Ul-Haq M Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms. 2011 Int J Anal Chem pmid:21760789
Abdulrahman SA and Basavaiah K Sensitive and selective spectrophotometric determination of gabapentin in capsules using two nitrophenols as chromogenic agents. 2011 Int J Anal Chem pmid:21760787
Zenita O and Basavaiah K Utility of N-bromosuccinimide for the titrimetric and spectrophotometric determination of famotidine in pharmaceutical formulations. 2011 Int J Anal Chem pmid:21760785
Almer G et al. Adiponectin-coated nanoparticles for enhanced imaging of atherosclerotic plaques. 2011 Int J Nanomedicine pmid:21753879
Brown JD et al. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. 2011 PLoS ONE pmid:21750705
Lacaze C et al. The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. 2011 Malar. J. pmid:21605361
Houmard JA et al. Is there a metabolic program in the skeletal muscle of obese individuals? 2011 J Obes pmid:21603262
Li C et al. Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. 2011 Carcinogenesis pmid:21586513
Mahdi ES et al. Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. 2011 Drug Des Devel Ther pmid:21792294
Kalinina OV et al. Combinations of protein-chemical complex structures reveal new targets for established drugs. 2011 PLoS Comput. Biol. pmid:21573205
Liu Y et al. Graphene and graphene oxide: two ideal choices for the enrichment and ionization of long-chain fatty acids free from matrix-assisted laser desorption/ionization matrix interference. 2011 Rapid Commun. Mass Spectrom. pmid:22006384
Fabiano A et al. Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. 2011 J. Matern. Fetal. Neonatal. Med. pmid:21781003
Santos GM et al. Negative regulation by nuclear receptors: a plethora of mechanisms. 2011 Trends Endocrinol. Metab. pmid:21196123
Watanabe H et al. Biosynthetic Pathway for Sex Pheromone Components Produced in a Plusiinae Moth, Plusia festucae. 2011 Front Endocrinol (Lausanne) pmid:22649385
Yee JK et al. Organ-specific alterations in fatty acid de novo synthesis and desaturation in a rat model of programmed obesity. 2011 Lipids Health Dis pmid:21569358
Shivanand K et al. In vivo bioavailability studies of sumatriptan succinate buccal tablets. 2011 Daru pmid:22615661
Gande S and Rao Y Sustained-release effervescent floating matrix tablets of baclofen: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. 2011 Daru pmid:22615658
Varshosaz J et al. Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats. 2011 Daru pmid:22615647
Dey S et al. Formulation and optimization of sustained release Stavudine microspheres using response surface methodology. 2011 ISRN Pharm pmid:22389855
Flowers MT et al. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. 2011 PLoS ONE pmid:21573029
Dasu MR and Jialal I Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959532
Kouskoumvekaki I and Panagiotou G Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules. 2011 J. Biomed. Biotechnol. pmid:20936122
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Kasliwal N et al. Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. 2011 Arch. Pharm. Res. pmid:22076769
Asahi H et al. Plasmodium falciparum: differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium. 2011 Exp. Parasitol. pmid:21095186
Kushner J et al. Examining the impact of excipient material property variation on drug product quality attributes: a quality-by-design study for a roller compacted, immediate release tablet. 2011 J Pharm Sci pmid:21319161
de Sousa Neto D et al. Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I). 2011 Chem. Phys. Lipids pmid:21238439
Seow LJ et al. Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. 2011 J Ethnopharmacol pmid:21167271
Price ER et al. Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21153644
Lin Y et al. Nucleating effect of calcium stearate coated CaCO(3) nanoparticles on polypropylene. 2011 J Colloid Interface Sci pmid:21122873
MacDonald AM et al. A modified supported bilayer/diblock polymer--working towards a tunable coating for capillary electrophoresis. 2011 J Chromatogr A pmid:21122870
Liu X et al. Synthesis of high quality and stability CdS quantum dots with overlapped nucleation-growth process in large scale. 2011 J Colloid Interface Sci pmid:21040929
Liu H et al. A surfactant-free recipe for shape-controlled synthesis of CdSe nanocrystals. 2011 Nanotechnology pmid:21169661
Pingali K et al. Mixing order of glidant and lubricant--influence on powder and tablet properties. 2011 Int J Pharm pmid:21356286
Zaki Rizkalla CM et al. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. 2011 AAPS PharmSciTech pmid:21800216
Roblegg E et al. Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. 2011 Eur J Pharm Biopharm pmid:21801834
Van Hoeck V et al. Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. 2011 PLoS ONE pmid:21858021
El Andaloussi S et al. Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. 2011 Methods Mol. Biol. pmid:21748634
Li Y et al. Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. 2011 Chem. Commun. (Camb.) pmid:21755081
Morinaga N et al. Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. 2011 Enzyme Microb. Technol. pmid:22113022
Kumar A et al. Phytochemical investigation and antifeedant activity of Premna latifolia leaves. 2011 Nat. Prod. Res. pmid:21756197
Hirose A et al. Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats. 2011 J. Pharmacol. Sci. pmid:21757842
Choi SE et al. Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. 2011 Nutr Res pmid:21745629
Fameau AL et al. Smart foams: switching reversibly between ultrastable and unstable foams. 2011 Angew. Chem. Int. Ed. Engl. pmid:21780260
Perrault M et al. An experimental investigation of the effect of the amount of lubricant on tablet properties. 2011 Drug Dev Ind Pharm pmid:20704461
Cheng YY et al. A novel cold-adapted lipase from Sorangium cellulosum strain So0157-2: gene cloning, expression, and enzymatic characterization. 2011 Int J Mol Sci pmid:22072918
Peng Q et al. A novel esterase gene cloned from a metagenomic library from neritic sediments of the South China Sea. 2011 Microb. Cell Fact. pmid:22067554
Yu WL et al. Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. 2011 Microb. Cell Fact. pmid:22047615
Someshwar K et al. Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride. 2011 Acta Pharm pmid:21684848
Sekharan TR et al. Formulation and Evaluation of Hydroxypropyl Methylcellulose-based Controlled Release Matrix Tablets for Theophylline. 2011 Indian J Pharm Sci pmid:22707833
Pani NR et al. Compatibility studies of nateglinide with excipients in immediate release tablets. 2011 Acta Pharm pmid:21684850
Němcová-Fürstová V et al. Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction. 2011 Cell. Physiol. Biochem. pmid:21691070
Xu M et al. Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. 2011 J. Biol. Chem. pmid:21697096
White HM et al. Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. 2011 J. Dairy Sci. pmid:21700028
Farboud ES et al. Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. 2011 Int J Nanomedicine pmid:21674018
Tiţa B et al. Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms. 2011 J Pharm Biomed Anal pmid:21665404
Mercado FV et al. Phase diagram of mixed monolayers of stearic acid and dimyristoylphosphatidylcholine. Effect of the acid ionization. 2011 Chem. Phys. Lipids pmid:21635875
Abbasi M et al. siRNA-mediated down-regulation of P-glycoprotein in a Xenograft tumor model in NOD-SCID mice. 2011 Pharm. Res. pmid:21638135
Lee YJ and Jenkins TC Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. 2011 J. Nutr. pmid:21653571