stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Maphalla TG and Emmambux MN | Functionality of maize, wheat, teff and cassava starches with stearic acid and xanthan gum. | 2016 | Carbohydr Polym | pmid:26572436 |
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Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
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Monteyne T et al. | Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. | 2016 | Int J Pharm | pmid:27452420 |
Ariyasu A et al. | Delay effect of magnesium stearate on tablet dissolution in acidic medium. | 2016 | Int J Pharm | pmid:27444551 |
Schulze C et al. | A one-stage cultivation process for lipid- and carbohydrate-rich biomass of Scenedesmus obtusiusculus based on artificial and natural water sources. | 2016 | Bioresour. Technol. | pmid:27394996 |
MužÃková J and KubÃÄková A | A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride. | 2016 | Acta Pharm | pmid:27383891 |
Yang D et al. | Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine. | 2016 | Anticancer Res. | pmid:27354583 |
Liu H et al. | Self-assembled dual-modality contrast agents for non-invasive stem cell tracking via near-infrared fluorescence and magnetic resonance imaging. | 2016 | J Colloid Interface Sci | pmid:27299677 |
Démuth B et al. | Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion. | 2016 | J Pharm Sci | pmid:27290626 |
Meng T et al. | A spermine conjugated stearic acid-g-chitosan oligosaccharide polymer with different types of amino groups for efficient p53 gene therapy. | 2016 | Colloids Surf B Biointerfaces | pmid:27289311 |
Schrank S et al. | Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. | 2016 | Int J Pharm | pmid:27282540 |
Eltayeb M et al. | Electrosprayed nanoparticle delivery system for controlled release. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:27207047 |
Zhao H et al. | Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. | 2016 | Phys Chem Chem Phys | pmid:27170421 |
Afonso MS et al. | Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. | 2016 | J. Nutr. Biochem. | pmid:27142741 |
Haware RV et al. | Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. | 2016 | Eur J Pharm Sci | pmid:27108117 |
Wang HJ et al. | Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. | 2016 | J Mater Sci Mater Med | pmid:26979976 |
Cheng CL et al. | Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. | 2016 | Dig Liver Dis | pmid:26976784 |
Moazeni M et al. | Time to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. | 2016 | Colloids Surf B Biointerfaces | pmid:26974361 |
Lu H et al. | Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. | 2016 | Diabetologia | pmid:26969487 |
Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26739624 |
Adler C et al. | Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion. | 2016 | Int J Pharm | pmid:26721729 |
Wood MH et al. | Comparative Adsorption of Saturated and Unsaturated Fatty Acids at the Iron Oxide/Oil Interface. | 2016 | Langmuir | pmid:26707597 |
Bothun GD et al. | Cooperative effects of fatty acids and n-butanol on lipid membrane phase behavior. | 2016 | Colloids Surf B Biointerfaces | pmid:26700234 |
Uvanesh K et al. | Effect of Span 60 on the Microstructure, Crystallization Kinetics, and Mechanical Properties of Stearic Acid Oleogels: An In-Depth Analysis. | 2016 | J. Food Sci. | pmid:26677007 |
Toral PG et al. | Does supplemental 18:0 alleviate fish oil-induced milk fat depression in dairy ewes? | 2016 | J. Dairy Sci. | pmid:26627853 |
Seethamraju S et al. | Reactive interlayer based ultra-low moisture permeable membranes for organic photovoltaic encapsulation. | 2015 | Phys Chem Chem Phys | pmid:26278515 |
Yang W et al. | Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging. | 2015 | ACS Appl Mater Interfaces | pmid:26257133 |
Zhong T et al. | Effects of ultrasound treatment on lipid self-association and properties of methylcellulose/stearic acid blending films. | 2015 | Carbohydr Polym | pmid:26256202 |
He H et al. | VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. | 2015 | Int J Pharm | pmid:26253378 |
Xu W et al. | Bilayers at High pH in the Fatty Acid Soap Systems and the Applications for the Formation of Foams and Emulsions. | 2015 | J Phys Chem B | pmid:26237503 |
Hoffmann M et al. | Investigation into process-induced de-aggregation of cohesive micronised API particles. | 2015 | Int J Pharm | pmid:26235919 |
Gong X et al. | Dependence of tablet brittleness on tensile strength and porosity. | 2015 | Int J Pharm | pmid:26226338 |
Liu G et al. | Cell membrane-inspired polymeric micelles as carriers for drug delivery. | 2015 | Biomater Sci | pmid:26222292 |
Qu L et al. | Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. | 2015 | Eur J Pharm Sci | pmid:26215464 |
Hong J et al. | Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition. | 2015 | Meat Sci. | pmid:26172243 |
Park JH et al. | Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. | 2015 | Int J Pharm | pmid:26149935 |
de Paiva EJ et al. | Influence of two different alcohols in the esterification of fatty acids over layered zinc stearate/palmitate. | 2015 | Bioresour. Technol. | pmid:26143001 |
Ricci M et al. | Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid. | 2015 | Langmuir | pmid:26087312 |
Santos IC et al. | Paired-ion electrospray ionization--triple quadrupole tandem mass spectrometry for quantification of anionic surfactants in waters. | 2015 | Talanta | pmid:26078166 |
Rizzuti B et al. | Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation. | 2015 | Arch. Biochem. Biophys. | pmid:26048999 |
Cárdenas V et al. | Strategy for design NIR calibration sets based on process spectrum and model space: An innovative approach for process analytical technology. | 2015 | J Pharm Biomed Anal | pmid:26001330 |
de Sousa FF et al. | Low-temperature phase transformation studies in the stearic acid: C form. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25909902 |
Patil H et al. | Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. | 2015 | Int J Pharm | pmid:25863118 |
Bera H et al. | Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone. | 2015 | Int. J. Biol. Macromol. | pmid:25861741 |
Badal Tejedor M et al. | Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure. | 2015 | Int J Pharm | pmid:25841569 |
Thakkar A et al. | Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. | 2015 | Int. J. Oncol. | pmid:25652350 |
Sagiri SS et al. | Stearic acid based oleogels: a study on the molecular, thermal and mechanical properties. | 2015 | Mater Sci Eng C Mater Biol Appl | pmid:25579972 |
Rana S et al. | A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. | 2015 | J Control Release | pmid:25575863 |
Wei X et al. | Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. | 2015 | Carbohydr Polym | pmid:25542116 |
Zeng Q et al. | Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. | 2015 | J Control Release | pmid:25540903 |
Piantoni P et al. | Milk production responses to dietary stearic acid vary by production level in dairy cattle. | 2015 | J. Dairy Sci. | pmid:25529423 |
Vercruysse J et al. | Use of a continuous twin screw granulation and drying system during formulation development and process optimization. | 2015 | Eur J Pharm Biopharm | pmid:25528462 |
Schrank S et al. | The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. | 2015 | Int J Pharm | pmid:25526671 |
Foraita S et al. | Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. | 2015 | Chemistry | pmid:25504844 |
Yan S et al. | Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. | 2015 | Fungal Genet. Biol. | pmid:25498164 |
Yang Y et al. | Ligand-directed stearic acid grafted chitosan micelles to increase therapeutic efficacy in hepatic cancer. | 2015 | Mol. Pharm. | pmid:25495890 |
Yi HX et al. | Effect of anionic PEGylated polypeptide on gene transfection mediated by glycolipid conjugate micelles. | 2015 | Mol. Pharm. | pmid:25490413 |
Leonardi A et al. | Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit. | 2015 | Int J Pharm | pmid:25448580 |
Bootello MA et al. | Effect of solvents on the fractionation of high oleic-high stearic sunflower oil. | 2015 | Food Chem | pmid:25442612 |
Thakral NK et al. | Compression-induced crystallization of amorphous indomethacin in tablets: characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. | 2015 | Mol. Pharm. | pmid:25438193 |
Liu Z et al. | Process optimization and kinetic evaluation for biosynthesis of D-isoascorbyl stearate. | 2015 | Bioprocess Biosyst Eng | pmid:25407728 |
Askari M et al. | Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. | 2015 | Clin Transl Oncol | pmid:25351172 |
Cantor SL et al. | Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. | 2015 | Drug Dev Ind Pharm | pmid:25000481 |
Qu L et al. | Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. | 2015 | Drug Dev Ind Pharm | pmid:24738790 |
Momoh MA et al. | Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres. | 2015 | Drug Deliv | pmid:24670092 |
Mohanty B et al. | Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery. | 2015 | Pharm Dev Technol | pmid:24490828 |
Guadalupe Sánchez-González E et al. | The influence of polymorphism on the manufacturability and in vitro dissolution of sulindac-containing hard gelatin capsules. | 2015 | Pharm Dev Technol | pmid:24417644 |
Van Hoeck V et al. | Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations. | 2015 | Reprod. Fertil. Dev. | pmid:24360349 |
Doignon F et al. | Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. | 2015 | Mol. Cell. Biol. | pmid:26711260 |
Miyazaki Y et al. | Dry Powder Coating using Planetary Centrifugal Mixer. | 2015 | J Pharm Pharm Sci | pmid:26517137 |
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Conde-Sieira M et al. | Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26468264 |
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Liu Z et al. | A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. | 2015 | Sci Rep | pmid:26400022 |
Miao H et al. | Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. | 2015 | Sci Rep | pmid:26271607 |
Soliman HM et al. | Utilization of Stearic acid Extracted from Olive Pomace for Production of Triazoles, Thiadiazoles and Thiadiazines Derivatives of Potential Biological Activities. | 2015 | J Oleo Sci | pmid:26250422 |
Jung SW et al. | Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. | 2015 | PLoS ONE | pmid:25793403 |
Othman AR et al. | Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. | 2015 | BMC Complement Altern Med | pmid:25652309 |
Aardema H et al. | Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. | 2015 | J. Dairy Sci. | pmid:25648816 |
Ma W et al. | Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. | 2015 | Am. J. Clin. Nutr. | pmid:25527759 |
Veselỳ M et al. | Photocatalytic and Antimicrobial Activity of Printed Hybrid Titania/Silica Layers. | 2015 | J Nanosci Nanotechnol | pmid:26716211 |
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Sasakura D et al. | Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy. | 2015 | Pharmazie | pmid:26601418 |