stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Dermatitis D003872 30 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Hyperlipidemias D006949 73 associated lipids
Bronchitis D001991 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
Prostatic Diseases D011469 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Insulin Resistance D007333 99 associated lipids
Obesity, Abdominal D056128 3 associated lipids
Rosacea D012393 13 associated lipids
Amnesia D000647 12 associated lipids
Gonorrhea D006069 7 associated lipids
Calculi D002137 3 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Yaws D015001 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Chancroid D002602 4 associated lipids
Relapsing Fever D012061 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Liu K et al. Isolation and biochemical characterization of two lipases from a metagenomic library of China Holstein cow rumen. 2009 Biochem. Biophys. Res. Commun. pmid:19486892
Canuto RA et al. Changes of adenylate cyclase activity in AH-130 ascites hepatoma of Yoshida induced by enrichment with fatty acids. 1995 Biochem. Biophys. Res. Commun. pmid:7654247
DAVIDOFF F and KORN ED Synthesis of unsaturated fatty acids in the cellular slime mold. 1962 Biochem. Biophys. Res. Commun. pmid:14025332
Ntambi JM et al. A model cell line to study regulation of stearoyl-CoA desaturase gene 1 expression by insulin and polyunsaturated fatty acids. 1996 Biochem. Biophys. Res. Commun. pmid:8607881
Robert S et al. Fatty acid acylation of RNase A using reversed micelles as microreactors. 1993 Biochem. Biophys. Res. Commun. pmid:7692851
Lu ZH et al. Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. 2003 Biochem. Biophys. Res. Commun. pmid:12684033
Eitel K et al. Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. 2002 Biochem. Biophys. Res. Commun. pmid:12470657
Slomiany A et al. Isolation of fatty acids covalently bound to the gastric mucus glycoprotein of normal and cystic fibrosis patients. 1983 Biochem. Biophys. Res. Commun. pmid:6860340
Yonezawa T et al. Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. 2004 Biochem. Biophys. Res. Commun. pmid:14741707
Lu B et al. Characterization of modified staphylococcal protein A containing phospholipid monolayer on both solution and slide surfaces. 1994 Biochem. Biophys. Res. Commun. pmid:8185601
Watanabe R et al. Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin. 1994 Biochem. Biophys. Res. Commun. pmid:8166694
Baines DL et al. Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. 2001 Biochem. Biophys. Res. Commun. pmid:11676504
Pan PH et al. Stearic acid attenuates cholestasis-induced liver injury. 2010 Biochem. Biophys. Res. Commun. pmid:20036638
Song MJ et al. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. 2006 Biochem. Biophys. Res. Commun. pmid:16781673
Rendu F et al. Platelet membrane molecular organization: relationship with membrane bound calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983699
Meng Y et al. Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. 2017 Biochem. Biophys. Res. Commun. pmid:28712865
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Yonezawa T et al. Saturated fatty acids stimulate and insulin suppresses BMCP1 expression in bovine mammary epithelial cells. 2009 Biochem. Biophys. Res. Commun. pmid:19852928
Raeside JI and Christie HL Diaryl dimers of estradiol and of estrone may be formed as major metabolites by mouse mammary glands. 2010 Biochem. Biophys. Res. Commun. pmid:20875396
Fanjul LF et al. Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells. 1992 Biochem. Biophys. Res. Commun. pmid:1329745
Yonezawa T et al. Saturated fatty acids stimulate and insulin suppresses CIDE-A expression in bovine mammary epithelial cells. 2009 Biochem. Biophys. Res. Commun. pmid:19427838
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
Yonezawa T et al. Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells. 2008 Biochem. Biophys. Res. Commun. pmid:18755148
Tetzloff SU and Bizzozero OA Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids. 1993 Biochem. Biophys. Res. Commun. pmid:8323550
Mock T et al. Effects of fatty acids on phosphatidylcholine biosynthesis in isolated hamster heart. 1986 Biochem. Cell Biol. pmid:3013250
Fletcher JE et al. Fatty acids modulate calcium-induced calcium release from skeletal muscle heavy sarcoplasmic reticulum fractions: implications for malignant hyperthermia. 1990 Biochem. Cell Biol. pmid:2125224
Fujii T et al. Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. 1986 Biochem. Int. pmid:3741447
Muralidharan FN and Muralidharan VB Phytanoyl-CoA ligase activity in rat liver. 1986 Biochem. Int. pmid:3753503
Urquhart R et al. omega-6 and omega-3 fatty acids: monolayer packing and effects on bilayer permeability and cholesterol exchange. 1992 Biochem. Int. pmid:1535197
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
LEAT WM FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. 1963 Biochem. J. pmid:14097364
TINOCO J et al. LIVER LIPIDS OF CHOLINE-DEFICIENT RATS. 1965 Biochem. J. pmid:14345885
Dudley DT et al. Depletion of arachidonic acid from GH3 cells. Effects on inositol phospholipid turnover and cellular activation. 1987 Biochem. J. pmid:3120699
Crosby T et al. Identification of ecdysone 22-long-chain fatty acyl esters in newly laid eggs of the cattle tick Boophilus microplus. 1986 Biochem. J. pmid:3030275
GLASCOCK RF and REINIUS LR Studies on the origin of milk fat. 1. The location of tritium in stearic acid produced by the catalytic addition of tritium to elaidic acid. 1956 Biochem. J. pmid:13315207
Wahle KW and Garton GA Desaturation of stearate by sheep tissue microsomal preparations. 1972 Biochem. J. pmid:4643297
Dudley DT and Spector AA Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. 1986 Biochem. J. pmid:3098231
COOKE NJ et al. The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). 1956 Biochem. J. pmid:13363830
DAWSON RM The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. 1958 Biochem. J. pmid:13522653
Bruce JS and Salter AM Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes. 1996 Biochem. J. pmid:8670161
Hasegawa K et al. Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH. 2008 Biochem. J. pmid:18637792
Bolton P and Harwood JL Fatty acid biosynthesis by a particulate preparation from germinating pea. 1977 Biochem. J. pmid:579600
Véret J et al. Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. 2011 Biochem. J. pmid:21592087
Yamamoto A and Kawashima Y Perfluorodecanoic acid enhances the formation of oleic acid in rat liver. 1997 Biochem. J. pmid:9230124
Weaire PJ and Kekwick RG The fractionation of the fatty acid synthetase activities of avocado mesocarp plastids. 1975 Biochem. J. pmid:1156381
Foot M et al. Some properties, including the substrate in vivo, of the delta 9-desaturase in Micrococcus cryophilus. 1983 Biochem. J. pmid:6847622
Zhao H and Hardy RW Long-chain saturated fatty acids induce annexin II translocation to detergent-resistant membranes. 2004 Biochem. J. pmid:15099193
Veit M et al. Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. 1996 Biochem. J. pmid:8761467
Agarwal HC and Nair AM Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). 1976 Biochem. J. pmid:962852
Anderton P et al. Measles-virus-persistent infection in BGM cells. Modification of the incorporation of [3H]arachidonic acid and [14C]stearic acid into lipids. 1983 Biochem. J. pmid:6414459
Zhang L et al. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. 2001 Biochem. J. pmid:11415448
Kemp P and Lander DJ The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. 1983 Biochem. J. pmid:6318740
Trinchera M et al. Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts. 1988 Biochem. J. pmid:3415659
Schlame M et al. Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species. 1990 Biochem. J. pmid:2154183
Graham A et al. Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes. 1988 Biochem. J. pmid:3355493
Russell NJ and Harwood JL Changes in the acyl lipid composition of photosynthetic bacteria grown under photosynthetic and non-photosynthetic conditions. 1979 Biochem. J. pmid:115463
Sanchez J et al. Lipase-induced alterations of fatty acid synthesis by subcellular fractions from germinating pea (Pisum sativum L.). 1982 Biochem. J. pmid:7115342
Le Jossic-Corcos C et al. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. 2005 Biochem. J. pmid:15473864
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Price CJ and Rowe CE Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine. 1972 Biochem. J. pmid:5075269
Faas FH and Carter WJ Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism. 1982 Biochem. J. pmid:7181859
DUNCOMBE WG and GLASCOCK RF The contribution of dietary stearic acid to milk fat. 1954 Biochem. J. pmid:13172205
BERGSTROM S et al. Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. 1954 Biochem. J. pmid:13230010
Jordan BR and Harwood JL Fatty acid elongation by a particulate fraction from germinating pea. 1980 Biochem. J. pmid:7283974
Faas FH and Carter WJ Fatty-acid desaturation and microsomal lipid fatty-acid composition in experimental hyperthyroidism. 1981 Biochem. J. pmid:7305962
NOBLE RC and MOORE JH FURTHER STUDIES ON THE LIPID METABOLISM OF THE NORMAL AND VITAMIN B-12 DEFICIENT CHICK EMBRYO. 1965 Biochem. J. pmid:14333549
JAMES AT and MARTIN AJ Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. 1956 Biochem. J. pmid:13315260
SRIDHARA S and BHAT JV FURTHER INVESTIGATIONS OF THE INCORPORATION OF (1-14C)ACETATE INTO THE LIPIDS OF THE SILKWORM BOMBYX MORI L. 1965 Biochem. J. pmid:14340061
GLASCOCK RF and REINIUS LR Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. 1954 Biochem. J. pmid:13230049
ROOTS BI and JOHNSTON PV LIPIDS OF ISOLATED NEURONS. 1965 Biochem. J. pmid:14342249
Walker KA and Harwood JL Localization of chloroplastic fatty acid synthesis de novo in the stroma. 1985 Biochem. J. pmid:3994672
Light ND and Bailey AJ Polymeric C-terminal cross-linked material from type-I collagen. A modified method for purification, anomalous behaviour on gel filtration, molecular weight estimation, carbohydrate content and lipid content. 1980 Biochem. J. pmid:7458897
Cardoso CM and De Meis L Modulation by fatty acids of Ca2+ fluxes in sarcoplasmic-reticulum vesicles. 1993 Biochem. J. pmid:7504458
Griffiths G et al. The acylation of sn-glycerol 3-phosphate and the metabolism of phosphatidate in microsomal preparations from the developing cotyledons of safflower (Carthamus tinctorius L.) seed. 1985 Biochem. J. pmid:4052051
Trinchera M et al. Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. 1990 Biochem. J. pmid:2241913
Doering TL et al. The fatty acids in unremodelled trypanosome glycosyl-phosphatidylinositols. 1994 Biochem. J. pmid:8192662
McIlhinney RA and McGlone K Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. 1990 Biochem. J. pmid:2244873
Giudici TA et al. Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. 1986 Biochem. Med. Metab. Biol. pmid:2872907
Lurie E et al. N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. 1993 Biochem. Mol. Biol. Int. pmid:8358340
Melik-Nubarov NS et al. Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. 1993 Biochem. Mol. Biol. Int. pmid:8508145
Ohyama H et al. Age-related differences in synaptosomal membrane fluidity. 1995 Biochem. Mol. Biol. Int. pmid:8653075
Croxtall JD et al. Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. 1994 Biochem. Pharmacol. pmid:8304964
Erman A et al. Phospholipase A2 inhibitors. Differential inhibition of fatty acid acylation into kidney lipids by mepacrine and p-bromophenacyl bromide. 1983 Biochem. Pharmacol. pmid:6870935
Ondrias K et al. Spin label study of the perturbation effect of the local anaesthetics tetracaine and dibucaine on synaptosomes at pharmacological concentrations. 1987 Biochem. Pharmacol. pmid:2825709
Risé P et al. Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines. 2005 Biochem. Pharmacol. pmid:15763545
Hara A et al. Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. 2017 Biochem. Pharmacol. pmid:28450226
Rendu F et al. Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. 1989 Biochem. Pharmacol. pmid:2539823
Kerr BD et al. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. 2009 Biochem. Pharmacol. pmid:19523458
Bruce JS et al. Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes. 1995 Biochem. Soc. Trans. pmid:7672331
Sherrington EJ et al. Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. 1996 Biochem. Soc. Trans. pmid:8736816
Kaushik N and Vir S Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. 2000 Biochem. Soc. Trans. pmid:11171243
Parveez GK et al. Transgenic oil palm: production and projection. 2000 Biochem. Soc. Trans. pmid:11171275
Clouet P et al. Mitochondrial respiration on rumenic and linoleic acids. 2001 Biochem. Soc. Trans. pmid:11356175
Liu Q et al. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. 2000 Biochem. Soc. Trans. pmid:11288706
Huber AH et al. Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin. 2006 Biochemistry pmid:17128966
Pohl EE et al. Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids. 2000 Biochemistry pmid:10677234
Feix JB et al. An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. 1984 Biochemistry pmid:6329270
Mogelson S and Lange LG Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. 1984 Biochemistry pmid:6487591