stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Mirabi P et al. Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid? 2017 Taiwan J Obstet Gynecol pmid:28420500
Noor NM et al. Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery. 2017 Eur J Pharm Biopharm pmid:28412472
Yang D et al. Liposomes Incorporating Transferrin and Stearic Acid-modified Octa-arginine for siRNA Delivery. 2017 Anticancer Res. pmid:28373438
Cevc G et al. Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures. 1988 Biochim. Biophys. Acta pmid:2835979
Ogata S et al. Chemical identification of lipid components in the membranous form of rat liver alkaline phosphatase. 1987 J. Biochem. pmid:2834351
Sapra M et al. Engineering of layered, lipid-encapsulated drug nanoparticles through spray-drying. 2017 Colloids Surf B Biointerfaces pmid:28340484
Guan Q et al. In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles. 2017 PLoS ONE pmid:28334044
Yang TS et al. Functionalities of chitosan conjugated with stearic acid and gallic acid and application of the modified chitosan in stabilizing labile aroma compounds in an oil-in-water emulsion. 2017 Food Chem pmid:28317761
Reddy TS and Bazan NG Arachidonic acid, stearic acid, and diacylglycerol accumulation correlates with the loss of phosphatidylinositol 4,5-bisphosphate in cerebrum 2 seconds after electroconvulsive shock: complete reversion of changes 5 minutes after stimulation. 1987 J. Neurosci. Res. pmid:2830409
Trementozzi AN et al. Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing. 2017 Int J Pharm pmid:28284921
Ondrias K et al. Spin label study of the perturbation effect of the local anaesthetics tetracaine and dibucaine on synaptosomes at pharmacological concentrations. 1987 Biochem. Pharmacol. pmid:2825709
Sguizzato M et al. Solid lipid nanoparticles for the delivery of 1,3,5-triaza-7-phosphaadamantane (PTA) platinum (II) carboxylates. 2017 Mater Sci Eng C Mater Biol Appl pmid:28254304
Lee W et al. Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. 2017 Sci Rep pmid:28250431
Crowley ME et al. Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data. 2017 Eur J Pharm Sci pmid:28216342
Feix JB et al. Interactions of 14N:15N stearic acid spin-label pairs: effects of host lipid alkyl chain length and unsaturation. 1987 Biochemistry pmid:2820479
Koranne S et al. Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry. 2017 Mol. Pharm. pmid:28195490
Shazly GA Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment. 2017 Biomed Res Int pmid:28194408
Lau M et al. Co-milled API-lactose systems for inhalation therapy: impact of magnesium stearate on physico-chemical stability and aerosolization performance. 2017 Drug Dev Ind Pharm pmid:28122460
Mirabi P et al. The role of fatty acids on ICSI outcomes: a prospective cohort study. 2017 Lipids Health Dis pmid:28109274
Burrows GE et al. A comparison of the various routes of administration of erythromycin in cattle. 1989 J. Vet. Pharmacol. Ther. pmid:2810478
Singh H et al. Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. 1989 J. Neurochem. pmid:2809586
Wan Y et al. Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery. 2017 Nanomedicine (Lond) pmid:28093948
Lau M et al. Investigation into the Manufacture and Properties of Inhalable High-Dose Dry Powders Produced by Comilling API and Lactose with Magnesium Stearate. 2017 AAPS PharmSciTech pmid:28070849
Zhou Y et al. An oxygen slow-releasing material and its application in water remediation as oxygen supplier. 2017 Environ Technol pmid:28041538
Skrede S et al. The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. 1989 Biochim. Biophys. Acta pmid:2804058
Cella C et al. Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis. 2017 Biomacromolecules pmid:28030952
Zhao L et al. Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity. 2017 FASEB J. pmid:28007782
Hsein H et al. Denatured Whey Protein Powder as a New Matrix Excipient: Design and Evaluation of Mucoadhesive Tablets for Sustained Drug Release Applications. 2017 Pharm. Res. pmid:28004316
Thirupathi G et al. Role of Isradipine Loaded Solid Lipid Nanoparticles on the Pharmacodynamic Effect in Rats. 2017 Drug Res (Stuttg) pmid:27992936
Dohi M et al. Application of Terahertz Attenuated Total Reflection Spectroscopy to Detect Changes in the Physical Properties of Lactose during the Lubrication Process Required for Drug Formulation. 2017 Chem. Pharm. Bull. pmid:27928130
Wahl PR et al. Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging. 2017 Int J Pharm pmid:27923700
Guan Q et al. Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation. 2016 Molecules pmid:27918445
Oyeyinka SA et al. Physicochemical and Mechanical Properties of Bambara Groundnut Starch Films Modified with Stearic Acid. 2017 J. Food Sci. pmid:27886659
De Weirdt R et al. Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. 2017 Environ. Microbiol. pmid:27883264
Mohsenin V and Gee JL Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. 1989 J. Appl. Physiol. pmid:2787317
Heim CB and Gillman JD Genotyping-by-Sequencing-Based Investigation of the Genetic Architecture Responsible for a ∼Sevenfold Increase in Soybean Seed Stearic Acid. 2017 G3 (Bethesda) pmid:27866151
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Anbalagan P et al. Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press. 2017 J Pharm Sci pmid:27842972
Delaney SP et al. Characterization of Synthesized and Commercial Forms of Magnesium Stearate Using Differential Scanning Calorimetry, Thermogravimetric Analysis, Powder X-Ray Diffraction, and Solid-State NMR Spectroscopy. 2017 J Pharm Sci pmid:27836109
Kelidari HR et al. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. 2017 AAPS PharmSciTech pmid:27834054
Hu Y et al. Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier. 2016 Oncotarget pmid:27825127
Dudhipala N and Veerabrahma K Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation. 2017 Eur J Pharm Biopharm pmid:27810472
Deasy PB and O'Neill CT Bioadhesive dosage form for peroral administration of timolol base. 1989 Pharm Acta Helv pmid:2780757
Song S et al. Identification of pork flavour precursors from enzyme-treated lard using Maillard model system assessed by GC-MS and partial least squares regression. 2017 Meat Sci. pmid:27792915
Paris A and Rao D Biosynthesis of estradiol-17 beta fatty acyl esters by microsomes derived from bovine liver and adrenals. 1989 J. Steroid Biochem. pmid:2779237
Shah RM et al. Microwave-assisted formulation of solid lipid nanoparticles loaded with non-steroidal anti-inflammatory drugs. 2016 Int J Pharm pmid:27789371
Männistö PT et al. Efficacy of erythromycin acistrate (2'-acetyl erythromycin stearate) and erythromycin stearate in experimental infections in mice. 1989 J. Pharmacol. Exp. Ther. pmid:2778707
Burke JP and Fenton MR Plasma and cellular zinc levels and membrane lipid composition in streptozotocin diabetic rats. 1989 Comp. Biochem. Physiol., B pmid:2776432
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Broderick PA Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin. 1989 Brain Res. pmid:2776030
Haeffner EW and Friedel R Induction of an endothermic transition in the Arrhenius plot of fatty acid uptake by lipid-depleted ascites tumor cells. 1989 Biochim. Biophys. Acta pmid:2775760
Kanasaki Y et al. Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. 2016 J Oleo Sci pmid:27725481
Bayard M et al. Free fatty acids and their esters modulate isothermal crystallization of anhydrous milk fat. 2017 Food Chem pmid:27719901
Han Y et al. Natural variations in stearoyl-acp desaturase genes affect the conversion of stearic to oleic acid in maize kernel. 2017 Theor. Appl. Genet. pmid:27717956
Mazel V et al. Reevaluation of the diametral compression test for tablets using the flattened disc geometry. 2016 Int J Pharm pmid:27702696
Narang AS et al. Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets. 2017 J Pharm Sci pmid:27686683
Souza AF et al. Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. 2016 Int J Mol Sci pmid:27669227
Qu L et al. Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression. 2017 J Pharm Sci pmid:27665128
Simon C et al. Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. 2016 Toxicol In Vitro pmid:27633901
Garba L et al. Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. 2016 Mol. Biotechnol. pmid:27629791
Kitajima J et al. [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. 1989 Yakugaku Zasshi pmid:2760813
Abreu P et al. Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. 2016 Exp. Physiol. pmid:27579497
Billès E et al. Cellulose oligomers production and separation for the synthesis of new fully bio-based amphiphilic compounds. 2016 Carbohydr Polym pmid:27577903
Nie H et al. Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. 2016 Mol. Pharm. pmid:27542728
Wada M et al. Mechanism of biosynthesis of unsaturated fatty acids in Pseudomonas sp. strain E-3, a psychrotrophic bacterium. 1989 J. Bacteriol. pmid:2753856
Passerini N et al. Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model. 2016 Int J Pharm pmid:27530293
Karthik S et al. Quillaja saponin: A prospective emulsifier for the preparation of solid lipid nanoparticles. 2016 Colloids Surf B Biointerfaces pmid:27521748
Christensen E et al. Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. 1989 Biochim. Biophys. Acta pmid:2752017
Ghate VM et al. Nanostructured lipid carriers for the topical delivery of tretinoin. 2016 Eur J Pharm Biopharm pmid:27519827
Krasnou I et al. Permeability of water and oleic acid in composite films of phase separated polypropylene and cellulose stearate blends. 2016 Carbohydr Polym pmid:27516292
Ohiri RC and Bassey EE Gas Chromatography-Mass Spectrometry Analysis of Constituent Oil from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from Nigeria. 2016 Int J Med Mushrooms pmid:27481303
Teh SS et al. Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification. 2016 J Oleo Sci pmid:27477075
Biesalski HK and Weiser H Sensitive analysis of retinyl esters by isocratic adsorption chromatography. 1989 J. Clin. Chem. Clin. Biochem. pmid:2746165
Monteyne T et al. Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. 2016 Int J Pharm pmid:27452420
Ariyasu A et al. Delay effect of magnesium stearate on tablet dissolution in acidic medium. 2016 Int J Pharm pmid:27444551
Yamreudeewong W et al. Effect of antacid coadministration on the bioavailability of erythromycin stearate. 1989 Clin Pharm pmid:2743731
Kosukhin AB et al. [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. 1989 Mar-Apr Vopr. Med. Khim. pmid:2741412
Schulze C et al. A one-stage cultivation process for lipid- and carbohydrate-rich biomass of Scenedesmus obtusiusculus based on artificial and natural water sources. 2016 Bioresour. Technol. pmid:27394996
Mužíková J and Kubíčková A A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride. 2016 Acta Pharm pmid:27383891
Liu Q et al. Genetic enhancement of palmitic acid accumulation in cotton seed oil through RNAi down-regulation of ghKAS2 encoding β-ketoacyl-ACP synthase II (KASII). 2017 Plant Biotechnol. J. pmid:27381745
Sun Y et al. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. 2016 J. Lipid Res. pmid:27371261
Kumar R and Sinha VR Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). 2017 AAPS PharmSciTech pmid:27368921
Nelson B et al. Effect of Dietary-Resistant Starch on Inhibition of Colonic Preneoplasia and Wnt Signaling in Azoxymethane-Induced Rodent Models. Nutr Cancer pmid:27367460
Yang D et al. Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine. 2016 Anticancer Res. pmid:27354583
Beck JC et al. Growth of epithelium from a preneoplastic mammary outgrowth in response to mammary adipose tissue. 1989 In Vitro Cell. Dev. Biol. pmid:2732196
Brodersen R et al. Serum albumin binding of palmitate and stearate. Multiple binding theory for insoluble ligands. 1989 Eur. J. Biochem. pmid:2731550
Liu H et al. Self-assembled dual-modality contrast agents for non-invasive stem cell tracking via near-infrared fluorescence and magnetic resonance imaging. 2016 J Colloid Interface Sci pmid:27299677
Du H et al. Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene. 2016 BMC Plant Biol. pmid:27297560
Démuth B et al. Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion. 2016 J Pharm Sci pmid:27290626
Meng T et al. A spermine conjugated stearic acid-g-chitosan oligosaccharide polymer with different types of amino groups for efficient p53 gene therapy. 2016 Colloids Surf B Biointerfaces pmid:27289311
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
Thotakura N et al. Chitosan-Stearic Acid Based Polymeric Micelles for the Effective Delivery of Tamoxifen: Cytotoxic and Pharmacokinetic Evaluation. 2017 AAPS PharmSciTech pmid:27287243
Jeyanathan J et al. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. 2016 BMC Microbiol. pmid:27283157
Schrank S et al. Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. 2016 Int J Pharm pmid:27282540
Shur J et al. From single excipients to dual excipient platforms in dry powder inhaler products. 2016 Int J Pharm pmid:27262269
Eltayeb M et al. Electrosprayed nanoparticle delivery system for controlled release. 2016 Mater Sci Eng C Mater Biol Appl pmid:27207047
Zhao H et al. Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. 2016 Phys Chem Chem Phys pmid:27170421
Afonso MS et al. Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. 2016 J. Nutr. Biochem. pmid:27142741
Mitropoulos KA et al. The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles. 1989 Blood pmid:2713491
Mortimer BC et al. The effect of added monoacylglycerols on the removal from plasma of chylomicron-like emulsions injected intravenously in rats. 1989 Biochim. Biophys. Acta pmid:2713386