stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

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What functions are associated with stearic acid?


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What lipids are associated with stearic acid?

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What genes are associated with stearic acid?

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What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Slomiany BL et al. Lipid composition of the matrix of human submandibular salivary gland stones. 1982 Arch. Oral Biol. pmid:6958224
Ahmad SN et al. Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. 1990 Arch. Oral Biol. pmid:2281999
Mutalik S et al. Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. 2007 Arch. Pharm. Res. pmid:17366745
Lee SH et al. End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression. 2012 Arch. Pharm. Res. pmid:23054717
Kim IS and Oh IJ Preparation and characterization of stearic acid-pullulan nanoparticles. 2010 Arch. Pharm. Res. pmid:20512475
Kasliwal N et al. Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. 2011 Arch. Pharm. Res. pmid:22076769
Jeong SH and Park K Simple preparation of coated resin complexes and their incorporation into fast-disintegrating tablets. 2010 Arch. Pharm. Res. pmid:20191352
Yu BT et al. Enhanced liver targeting by synthesis of N1-stearyl-5-Fu and incorporation into solid lipid nanoparticles. 2003 Arch. Pharm. Res. pmid:14723346
Cha KH et al. Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. 2009 Arch. Pharm. Res. pmid:20091273
Peura P et al. The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. 1986 Arch. Toxicol. Suppl. pmid:3468932
Zhou X et al. The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. 2013 Archaea pmid:23710130
MALJKOVIC I [A CASE OF CHRONIC OCCUPATIONAL POISONING WITH LEAD STEARATE AND CARBONATE]. 1964 Arh Hig Rada Toksikol pmid:14342211
NadtochiÄ­ VV and BrodskiÄ­ RA [Absorption routes of stearic acid and leucine in the small intestine of the rat after gamma irradiation]. 1983 Arkh Anat Gistol Embriol pmid:6639383
Mitropoulos KA et al. Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. 1994 Arterioscler. Thromb. pmid:8305411
Anderson EK et al. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22556332
Turpeinen AM et al. Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9484999
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Tulenko TN and Rabinowitz JL Metabolism of C14 mevalonate by adult and fetal arteries. 1983 Artery pmid:6677248
Krzeski P et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. 2007 Arthritis Res. Ther. pmid:17958901
Chiang EP et al. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. 2005 Arthritis Res. Ther. pmid:16277693
Kumar Gaur P et al. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. 2016 Artif Cells Nanomed Biotechnol pmid:26375758
Yan G et al. Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. 2016 Artif Cells Nanomed Biotechnol pmid:25287740
Pradhan M et al. Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. 2016 Artif Cells Nanomed Biotechnol pmid:25229831
Chen Q et al. Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. 2015 Artif Cells Nanomed Biotechnol pmid:24093764
Tükel S et al. Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. 2013 Artif Cells Nanomed Biotechnol pmid:23305558
Wang W et al. Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide. 2017 Artif Cells Nanomed Biotechnol pmid:26754958
Sastri MS et al. In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. 1993 Arzneimittelforschung pmid:8489559
Männistö P et al. Absorption of erythromycin. A cross-over study in healthy volunteers. 1975 Arzneimittelforschung pmid:1106445
Asgary S et al. Evaluation of fatty acid content of some Iranian fast foods with emphasis on trans fatty acids. 2009 Asia Pac J Clin Nutr pmid:19713177
Cohn JS et al. Reduction in intestinal cholesterol absorption by various food components: mechanisms and implications. 2010 Atheroscler Suppl pmid:20439167
Ebbesson SO et al. Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. 2008 Atherosclerosis pmid:18054937
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
van Greevenbroek MM et al. Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. 1996 Atherosclerosis pmid:8678919
Berlin E et al. Influence of saturated and unsaturated fats on platelet fatty acids in cholesterol-fed rabbits. 1987 Atherosclerosis pmid:3827974
Sanders TA et al. Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). 2000 Atherosclerosis pmid:10729392
van Tol A et al. Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. 1995 Atherosclerosis pmid:7669083
Bonanome A et al. Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. 1992 Atherosclerosis pmid:1632865
Uehara Y et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. 2007 Atherosclerosis pmid:16730733
Spigoni V et al. Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. 2017 Atherosclerosis pmid:28892713
Artwohl M et al. Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. 2009 Atherosclerosis pmid:18597758
Ishikado A et al. Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. 2009 Atherosclerosis pmid:19215923
Cooksley WG and Powell LW Erythromycin jaundice: diagnosis by an in vitro challenge test. 1977 Aust N Z J Med pmid:269690
Green B et al. Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby (Macropus eugenii). 1983 Aust. J. Biol. Sci. pmid:6675645
Weber J et al. [Can zinc stearate cause lung fibrosis? (Case report)]. 1976 Beitr Silikoseforsch Pneumokoniose pmid:990095
Basseri S and Austin RC Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. 2012 Biochem Res Int pmid:22195283
ERWIN J and BLOCH K POLYUNSATURATED FATTY ACIDS IN SOME PHOTOSYNTHETIC MICROORGANISMS. 1963 Biochem Z pmid:14087318
Lu ZH et al. Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. 2003 Biochem. Biophys. Res. Commun. pmid:12684033
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954