stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hypothyroidism D007037 32 associated lipids
Dermatitis D003872 30 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Insulinoma D007340 28 associated lipids
Breast Neoplasms D001943 24 associated lipids
Cattle Diseases D002418 24 associated lipids
Birth Weight D001724 23 associated lipids
Bacterial Infections D001424 21 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Brain Edema D001929 20 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Ischemia D007511 18 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Lymphoma D008223 18 associated lipids
Olfaction Disorders D000857 17 associated lipids
Tremor D014202 15 associated lipids
Rosacea D012393 13 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Chen H et al. Effect of cholesterol on miscibility and phase behavior in binary mixtures with synthetic ceramide 2 and octadecanoic acid. Infrared studies. 2001 Biochim. Biophys. Acta pmid:11406112
Bieri VG and Wallach DF Variations of lipid-protein interactions in erythrocyte ghosts as a function of temperature and pH in physiological and non-physiological ranges. A study using a paramagnetic quenching of protein fluorescence by nitroxide lipid analogues. 1975 Biochim. Biophys. Acta pmid:241415
Zoeller RA and Wood R The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. 1985 Biochim. Biophys. Acta pmid:2860925
STEIN O and STEIN Y METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. 1963 Biochim. Biophys. Acta pmid:14085937
Christensen E et al. Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. 1989 Biochim. Biophys. Acta pmid:2752017
Morrow MR et al. Glycosphingolipid acyl chain order profiles: substituent effects. 1995 Biochim. Biophys. Acta pmid:7756331
Longmuir KJ and Rossi ME Fatty acid chain-shortening activity in the pulmonary type II cell. 1988 Biochim. Biophys. Acta pmid:3289622
Riordan JR et al. Plasma membrane lipids of human diploid fibroblasts from normal individuals and patients with cystic fibrosis. 1979 Biochim. Biophys. Acta pmid:476136
Eliasz AW et al. Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds. 1976 Biochim. Biophys. Acta pmid:971432
Kogure K et al. Effect of dicetylphosphate or stearic acid on spontaneous transfer of protein from influenza virus-infected cells to dimyristoylphosphatidylcholine liposomes. 1997 Biochim. Biophys. Acta pmid:9370255
Woldseth B et al. Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. 1993 Biochim. Biophys. Acta pmid:8481391
Aspbury RA et al. Fatty acylation of polypeptides in the nematode Caenorhabditis elegans. 1998 Biochim. Biophys. Acta pmid:9507081
Clandinin MT et al. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. 1997 Biochim. Biophys. Acta pmid:9219909
Sparks JD et al. Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. 1997 Biochim. Biophys. Acta pmid:9233686
Thompson W and Belina H Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. 1986 Biochim. Biophys. Acta pmid:3707975
Streichman S et al. Unique profile for erythrocyte membrane acetylcholinesterase in hereditary spherocytosis. 1983 Biochim. Biophys. Acta pmid:6849970
Schreiber R et al. Retinyl ester hydrolases and their roles in vitamin A homeostasis. 2012 Biochim. Biophys. Acta pmid:21586336
Beaumelle BD and Vial HJ Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. 1986 Biochim. Biophys. Acta pmid:3719005
Kordyukova LV et al. Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. 2011 Biochim. Biophys. Acta pmid:21420932
ELOVSON J METABOLISM OF SOME MONOHYDROXYSTEARIC ACIDS IN THE INTACT RAT. 1964 Biochim. Biophys. Acta pmid:14194233
Arukuusk P et al. New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. 2013 Biochim. Biophys. Acta pmid:23357356
DAVIDOFF FF THE METABOLISM OF 9(10)-HYDROXYSTEARIC ACID BY THE CELLULAR SLIME MOLD, DICTYOSTELIUM DISCOIDEUM. 1964 Biochim. Biophys. Acta pmid:14220732
Holub BJ The relative deacylation of different molecular species of endogenous phosphatidylethanolamine in rat liver microsomes by phospholipase activity. 1982 Biochim. Biophys. Acta pmid:7093298
MENZEL DB and OLCOTT HS POSITIONAL DISTRIBUTION OF FATTY ACIDS IN FISH AND OTHER ANIMAL LECITHINS. 1964 Biochim. Biophys. Acta pmid:14181289
DAY AJ et al. THE INCORPORATION OF 14-C-LABELLED ACETATE INTO LONG CHAIN FATTY ACIDS BY MACROPHAGES IN VITRO. 1964 Biochim. Biophys. Acta pmid:14181291
GELLHORN A and BENJAMIN W THE INTRACELLULAR LOCALIZATION OF AN ENZYMATIC DEFECT OF LIPID METABOLISM IN DIABETIC RATS. 1964 Biochim. Biophys. Acta pmid:14181293
IKAWA M OCCURRENCE AND IDENTIFICATION OF CIS-VACCENIC ACID IN LEUCONOSTOC MESENTEROIDES. 1964 Biochim. Biophys. Acta pmid:14181302
Slomiany BL et al. Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. 1986 Biochim. Biophys. Acta pmid:3518803
Streichman S et al. EPR study of the hydrophobic interaction of spectrin with fatty acids. 1991 Biochim. Biophys. Acta pmid:1648396
Cevc G et al. Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures. 1988 Biochim. Biophys. Acta pmid:2835979
Chien JL and Hogan EL Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. 1980 Biochim. Biophys. Acta pmid:7236652
Holub BJ The suitability of different acyl acceptors as substrates for the acyl-Coa : 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat liver microsomes. 1981 Biochim. Biophys. Acta pmid:7248321
DOBIASOVA M et al. FATTY ACID COMPOSITION IN DEVELOPING RATS. FATTY ACID COMPOSITION OF TRIGLYCERIDES AND PHOSPHOLIPIDS IN SOME ORGANS OF THE RAT DURING POSTNATAL DEVELOPMENT. 1964 Biochim. Biophys. Acta pmid:14250492
WILLEBRANDS AF UTILIZATION OF INDIVIDUAL NON-ESTERIFIED FATTY ACIDS BY THE ISOLATED PERFUSED RAT HEART. 1964 Biochim. Biophys. Acta pmid:14250498
Yoshida S et al. Effect of phospholipase A2 and free fatty acids on lipid-protein interactions in long- and very-long-chain fatty acyl-CoA elongation enzyme systems of brain microsomes. 1989 Biochim. Biophys. Acta pmid:2502180
Baker RR and Chang HY A comparison of lysophosphatidylcholine acyltransferase activities in neuronal nuclei and microsomes isolated from immature rabbit cerebral cortex. 1981 Biochim. Biophys. Acta pmid:7306562
George M and Chepenik KP Phospholipase A activities in embryonic palate mesenchyme cells in vitro. 1985 Biochim. Biophys. Acta pmid:3927980
SHAFRIR E et al. PARTITION OF FATTY ACIDS OF 20-24 CARBON ATOMS BETWEEN SERUM ALBUMIN AND LIPOPROTEINS. 1965 Biochim. Biophys. Acta pmid:14320230
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Kumar SS et al. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. 2014 Biochim. Biophys. Acta pmid:24440669
ELOVSON J CHAIN-SHORTENING OF STEARIC ACID IN THE INTACT RAT. 1965 Biochim. Biophys. Acta pmid:14290835
MCCARTHY RD et al. THE CONVERSION OF STEARIC ACID TO OLEIC IN FRESHLY SECRETED MILK. 1965 Biochim. Biophys. Acta pmid:14292868
Malmberg P et al. Localization of lipids in the aortic wall with imaging TOF-SIMS. 2007 Biochim. Biophys. Acta pmid:17240191
Lagrost L Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. 1992 Biochim. Biophys. Acta pmid:1543738
Mortimer BC et al. The effect of added monoacylglycerols on the removal from plasma of chylomicron-like emulsions injected intravenously in rats. 1989 Biochim. Biophys. Acta pmid:2713386
Skrede S et al. The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. 1989 Biochim. Biophys. Acta pmid:2804058
Golovina EA and Tikhonov AN The structural differences between the embryos of viable and nonviable wheat seeds as studied with the EPR spectroscopy of lipid-soluble spin labels. 1994 Biochim. Biophys. Acta pmid:8142440
Yoshida S and Takeshita M Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. 1984 Biochim. Biophys. Acta pmid:6466693
Miller RW and De La Roche IA Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. 1976 Biochim. Biophys. Acta pmid:182261
Ruf HH and Gratzl M Binding of nitroxide stearate spin labels to bovine serum albumin. 1976 Biochim. Biophys. Acta pmid:184832