stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Chen Y et al. A new method to obtain Fourier transform infrared spectra free from water vapor disturbance. 2010 Appl Spectrosc pmid:20925991
Mukherjee S et al. Stearic acid delivery to corneum from a mild and moisturizing cleanser. 2010 J Cosmet Dermatol pmid:20883293
Rideout TC et al. Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. 2010 Mol Nutr Food Res pmid:20333723
Rawat MK et al. Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. 2010 Ther Deliv pmid:22816120
Zornetzer GA et al. The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. 2010 Biochemistry pmid:20014832
Tay T et al. Magnesium stearate increases salbutamol sulphate dispersion: what is the mechanism? 2010 Int J Pharm pmid:19748561
Shen J et al. Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution. 2010 Int J Pharm pmid:20934499
Renaville B et al. Plasma and follicular fluid fatty acid profiles in dairy cows. 2010 Reprod. Domest. Anim. pmid:19055554
Varshosaz J et al. Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat. 2010 Int J Prev Med pmid:21566772
Alizadeh M et al. The effect of hypocaloric diet enriched in legumes with or without L-arginine and selenium on anthropometric measures in central obese women. 2010 J Res Med Sci pmid:21526106
Louis J et al. PAD4-dependent antibiosis contributes to the ssi2-conferred hyper-resistance to the green peach aphid. 2010 Mol. Plant Microbe Interact. pmid:20367470
Ospina-E JC et al. Development of combinations of chemically modified vegetable oils as pork backfat substitutes in sausages formulation. 2010 Meat Sci. pmid:20374815
Ye S et al. Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20206488
Rajab M et al. Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid. 2010 Pharmazie pmid:20225651
Araújo J et al. Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. 2010 Int J Pharm pmid:20362042
Bender K et al. Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. 2010 Reproduction pmid:20385782
Pedersen PJ et al. Liposomal formulation of retinoids designed for enzyme triggered release. 2010 J. Med. Chem. pmid:20405849
Ohwoavworhua FO and Adelakun TA Non-wood Fibre Production of Microcrystalline Cellulose from Sorghum caudatum: Characterisation and Tableting Properties. 2010 Indian J Pharm Sci pmid:21188036
El Hadrami A et al. Chitosan in plant protection. 2010 Mar Drugs pmid:20479963
Borah BM et al. Surface-modification-directed controlled adsorption of serum albumin onto magnetite nanocuboids synthesized in a gel-diffusion technique. 2010 J Colloid Interface Sci pmid:20621808
Zhu SH et al. [Study on the chemical constituents of Dichrocephala integrifolia]. 2010 Zhong Yao Cai pmid:20518304
Manickam E et al. Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes. 2010 Lipids Health Dis pmid:20525346
Luan L et al. [Studies on the chemical constituents of extract with water from Forsythia suspensa]. 2010 Zhong Yao Cai pmid:20575415
Contreras GA et al. Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids. 2010 J. Dairy Sci. pmid:20494158
Karande AD et al. In-line quantification of micronized drug and excipients in tablets by near infrared (NIR) spectroscopy: Real time monitoring of tabletting process. 2010 Int J Pharm pmid:20558264
A J et al. Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. 2010 PLoS ONE pmid:20949032
Thörn K et al. Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells. 2010 Lipids Health Dis pmid:20920255
Aly S Detachment and recovery index: A new parameter measuring powder compressibility. 2010 J Adv Pharm Technol Res pmid:22247881
Brown AW et al. Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase. 2010 J. Nutr. Biochem. pmid:19615880
Pires de Souza FC et al. In vitro comparison of the radiopacity of cavity lining materials with human dental structures. 2010 J Conserv Dent pmid:20859477
Lyra A et al. Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. 2010 BMC Gastroenterol pmid:20849659
Shishu VR et al. Development of taste masked oral formulation of ornidazole. 2010 Indian J Pharm Sci pmid:20838525
Gohel MC et al. Fabrication and Evaluation of Bi-layer Tablet Containing Conventional Paracetamol and Modified Release Diclofenac Sodium. 2010 Indian J Pharm Sci pmid:20838522
Do PT et al. The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. 2010 Plant Physiol. pmid:20841452
Tiemeyer S et al. Effect of surface charge distribution on the adsorption orientation of proteins to lipid monolayers. 2010 Langmuir pmid:20707324
Ye M et al. Synthesis of Sb2E3 (E = S, Se) nanorods with a flat cross section by a rapid hot injection method. 2010 J Nanosci Nanotechnol pmid:21138031
Xu Y et al. Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells. 2010 Int J Nanomedicine pmid:20463932
Harvey KA et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. 2010 J. Lipid Res. pmid:20852092
Prossnigg F et al. Packing behaviour of two predominant anionic phospholipids of bacterial cytoplasmic membranes. 2010 Biophys. Chem. pmid:20451316
Chitapanarux I et al. Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. 2010 Radiat Oncol pmid:20444243
Blanco M and Peguero A Influence of physical factors on the accuracy of calibration models for NIR spectroscopy. 2010 J Pharm Biomed Anal pmid:20044229
Howell AB et al. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. 2010 BMC Infect. Dis. pmid:20398248
UÄŸurlu T et al. Effects of lubricants on binary direct compression mixtures. 2010 Drug Discov Ther pmid:22491169
Shaikh SA et al. Formulation and evaluation of s-(-)-amlodipine besylate and nebivolol hydrochloride tablets. 2010 J Adv Pharm Technol Res pmid:22247846
Tiwari G et al. Cyclodextrins in delivery systems: Applications. 2010 J Pharm Bioallied Sci pmid:21814436
Hsieh HT et al. Facile synthesis of silver nanoparticles in CO2-expanded liquids from silver isostearate precursor. 2010 Langmuir pmid:20297774
Xing Z et al. Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate. 2010 Acta Biomater pmid:20226284
Choi JN et al. Metabolomics revealed novel isoflavones and optimal cultivation time of Cordyceps militaris fermentation. 2010 J. Agric. Food Chem. pmid:20225861
O'Byrne SM et al. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20040693
Desando MA et al. Proton magnetic relaxation and the aggregation of n-octylammonium n-octadecanoate surfactant in deuterochloroform solution. 2010 J Colloid Interface Sci pmid:20223468
Collins JM et al. De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. 2010 J. Biol. Chem. pmid:20032470
Xing Z et al. The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging. 2010 Nanotechnology pmid:20220227
Li Y et al. Preparation and characterization of coverage-controlled CaCO3 nanoparticles. 2010 J Colloid Interface Sci pmid:20202642
Salbu L et al. Direct compression behavior of low- and high-methoxylated pectins. 2010 AAPS PharmSciTech pmid:20013080
Kordyukova LV et al. Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. 2010 Virology pmid:20006369
Raeside JI and Christie HL Diaryl dimers of estradiol and of estrone may be formed as major metabolites by mouse mammary glands. 2010 Biochem. Biophys. Res. Commun. pmid:20875396
Zhang Y et al. The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity. 2010 J. Lipid Res. pmid:19609006
Romanowicz L and Bańkowski E Altered sphingolipid composition in Wharton's jelly of pre-eclamptic newborns. 2010 Pathobiology pmid:20332667
Zhang L et al. Fabrication of nanotubules and microspheres from the self-assembly of amphiphilic monochain stearic acid derivatives. 2010 Langmuir pmid:21049915
Zarbakhsh A et al. Stabilization of alkylated azacrown ether by fatty acid at the air-water interface. 2010 Langmuir pmid:21049946
Alshamsan A et al. Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine. 2009 Jan-Feb Mol. Pharm. pmid:19053537
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Roberts R et al. Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. 2009 Diabetologia pmid:19252892
Ishitsuka Y et al. Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. 2009 Biol. Pharm. Bull. pmid:19252304
Pingali KC et al. Use of a static eliminator to improve powder flow. 2009 Int J Pharm pmid:19266628
Shehab-El-Deen MA et al. Cryotolerance of bovine blastocysts is affected by oocyte maturation in media containing palmitic or stearic acid. 2009 Reprod. Domest. Anim. pmid:18992093
Malaterre V et al. Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems. 2009 J Control Release pmid:18840483
Burkhardt M et al. Macroscopic properties and microstructure of HSA based organogels: sensitivity to polar additives. 2009 J Colloid Interface Sci pmid:19144353
Chen Y et al. Observation of an amorphous calcium carbonate precursor on a stearic acid monolayer formed during the biomimetic mineralization of CaCO(3). 2009 Langmuir pmid:19099353
Mäe M et al. A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy. 2009 J Control Release pmid:19105971
Schmidt WF et al. Unit cell volume and liquid-phase immiscibility in oleate-stearate lipid mixtures. 2009 Chem. Phys. Lipids pmid:19150441
Chen CY et al. Chemical constituents from the whole plant of Gaultheria itoana Hayata. 2009 Chem. Biodivers. pmid:19842133
Pingali KC et al. Practical methods for improving flow properties of active pharmaceutical ingredients. 2009 Drug Dev Ind Pharm pmid:19929205
Le Guédard M et al. PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast. 2009 FEBS J. pmid:19796168
Shen J et al. Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. 2009 J Control Release pmid:19393270
Okada K et al. Effect of fatty acids added to the milk replacer on white scour and excretion of fatty acids in Holstein calves. 2009 Anim. Sci. J. pmid:20163618
Swamy PV et al. Preparation and evaluation of orodispersible tablets of pheniramine maleate by effervescent method. 2009 Indian J Pharm Sci pmid:20336216
Costa MC et al. The solid-liquid phase diagrams of binary mixtures of consecutive, even saturated fatty acids. 2009 Chem. Phys. Lipids pmid:19520067
Wei Y et al. Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. 2009 Mol. Cell. Biochem. pmid:19444596
Hoppa MB et al. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. 2009 Cell Metab. pmid:19945403
Weber K et al. Lesions in the Larynx of Wistar RccHan: WIST Rats. 2009 J Toxicol Pathol pmid:22271998
Kalman DS et al. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms. 2009 BMC Gastroenterol pmid:19922649
Fostok SF et al. Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus. 2009 BMC Complement Altern Med pmid:19917107
Evans LM et al. Stearate preferentially induces apoptosis in human breast cancer cells. 2009 Nutr Cancer pmid:19838949
Yarkala S et al. Role of excipients on N-oxide raloxifene generation from raloxifene-excipients binary mixtures. 2009 Chem. Pharm. Bull. pmid:19801885
Fujita M et al. Generation of formaldehyde by pharmaceutical excipients and its absorption by meglumine. 2009 Chem. Pharm. Bull. pmid:19801864
Kessler W et al. Using scattering and absorption spectra as MCR-hard model constraints for diffuse reflectance measurements of tablets. 2009 Anal. Chim. Acta pmid:19427467
Cha KH et al. Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. 2009 Arch. Pharm. Res. pmid:20091273
Hesta M et al. The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters. 2009 J Anim Physiol Anim Nutr (Berl) pmid:19386005
Thumma S and Repka MA Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. 2009 Pharmazie pmid:19348341
Bolhuis GK et al. Compaction properties of isomalt. 2009 Eur J Pharm Biopharm pmid:19327398
Staiger K et al. Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. 2009 Microvasc. Res. pmid:19327373
van Die MD et al. Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial. 2009 BMC Med Res Methodol pmid:19549306
Late SG et al. Effects of disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets. 2009 Int J Pharm pmid:18778759
Alloatti A et al. Chemical evaluation of fatty acid desaturases as drug targets in Trypanosoma cruzi. 2009 Int. J. Parasitol. pmid:19249306
Peter A et al. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. 2009 Diabetes pmid:19478146
Ussher JR et al. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. 2009 Diabetes pmid:19478144
Monajjemzadeh F et al. Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. 2009 AAPS PharmSciTech pmid:19455427
Nyadong L et al. Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuticals. 2009 Anal. Chem. pmid:19453162
Meng W et al. A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. 2009 Trials pmid:19419555