stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Chu X et al. Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia. 2013 Diabetes pmid:22966071
Hu FQ et al. Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles. 2013 Gene Ther. pmid:22951455
Sovány T et al. Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics. 2013 AAPS PharmSciTech pmid:23413109
Mirani ZA and Jamil N Role of extra-cellular fatty acids in vancomycin induced biofilm formation by vancomycin resistant Staphylococcus aureus. 2013 Pak J Pharm Sci pmid:23455211
Vervaeck A et al. Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms. 2013 Eur J Pharm Biopharm pmid:23474381
Risley DS et al. Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection. 2013 J Pharm Biomed Anal pmid:23474810
Zamora-Rojas E et al. Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. 2013 Meat Sci. pmid:23793086
Song W et al. Importance of size and distribution of Ni nanoparticles for the hydrodeoxygenation of microalgae oil. 2013 Chemistry pmid:23794421
Sharma P et al. Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. 2013 PLoS ONE pmid:23326499
Tükel S et al. Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. 2013 Artif Cells Nanomed Biotechnol pmid:23305558
Lee W et al. Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. 2013 J. Biol. Chem. pmid:23306194
Wu JH et al. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. 2013 Circ Cardiovasc Genet pmid:23362303
Arukuusk P et al. New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. 2013 Biochim. Biophys. Acta pmid:23357356
Khan AA et al. Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. 2013 Anticancer Res. pmid:23749903
Li C et al. Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. 2013 Sci Rep pmid:23712069
Lakio S et al. Challenges in detecting magnesium stearate distribution in tablets. 2013 AAPS PharmSciTech pmid:23378252
Järvinen MA et al. Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. 2013 Drug Dev Ind Pharm pmid:23163644
Yan J et al. Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. 2013 Mol. Pharm. pmid:23679858
Tammaro A et al. Magnesium stearate: an underestimated allergen. 2012 Oct-Dec J. Biol. Regul. Homeost. Agents pmid:23241129
Hentzschel CM et al. Comparison of traditional and novel tableting excipients: physical and compaction properties. 2012 Nov-Dec Pharm Dev Technol pmid:21740091
Khan FN and Dehghan MH Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives. 2012 Jan-Mar Sci Pharm pmid:22396916
Pujeri SS et al. Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method. 2012 Jan-Mar Sci Pharm pmid:22396908
Anderson EK et al. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22556332
Prashanth KN and Basavaiah K Sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent. 2012 J Anal Methods Chem pmid:22567567
de Souza Monteiro A et al. Bioconversion of biodiesel refinery waste in the bioemulsifier by Trichosporon mycotoxinivorans CLA2. 2012 Biotechnol Biofuels pmid:22559210
Samanta AK et al. Cone milling of compacted flakes: process parameter selection by adopting the minimal fines approach. 2012 Int J Pharm pmid:22001841
Yang P et al. Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. 2012 PLoS ONE pmid:22536429
Nagpal M et al. Formulation development and evaluation of alginate microspheres of Ibuprofen. 2012 J Young Pharm pmid:22523454
Tay T et al. Dissolution of a poorly water-soluble drug dry coated with magnesium and sodium stearate. 2012 Eur J Pharm Biopharm pmid:22036990
Vijay J et al. Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. 2012 J Young Pharm pmid:22523453
Baratta F et al. Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity. 2012 Croat. Med. J. pmid:22522996
Kwon Y et al. Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. 2012 Int J Mol Sci pmid:22489147
Arya A et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. 2012 Evid Based Complement Alternat Med pmid:22474512
Milicic A et al. Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. 2012 PLoS ONE pmid:22470545
Mason P et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. 2012 PLoS ONE pmid:22457791
Olivieri C et al. Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. 2012 PLoS ONE pmid:22457789
Quintela M et al. Estimation of the uncertainty associated with the results based on the validation of chromatographic analysis procedures: application to the determination of chlorides by high performance liquid chromatography and of fatty acids by high resolution gas chromatography. 2012 J Chromatogr A pmid:22227361
Schaab M et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. 2012 PLoS ONE pmid:22545089
Gabirot M et al. Differences in Chemical Sexual Signals May Promote Reproductive Isolation and Cryptic Speciation between Iberian Wall Lizard Populations. 2012 Int J Evol Biol pmid:22288019
Ghadiri M et al. Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size. 2012 Int J Pharm pmid:22227603
Kim S et al. Lipid-binding properties of TRIM72. 2012 BMB Rep pmid:22281009
Borbon IA et al. Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. 2012 Pharmacol. Biochem. Behav. pmid:22202649
El-Enany NM et al. Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma. 2012 Chem Cent J pmid:22277722
Scalia S et al. Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. 2012 J Microencapsul pmid:22208706
Anton N et al. A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets. 2012 J Drug Deliv pmid:22272376
Duong CT and Roper MG A microfluidic device for the automated derivatization of free fatty acids to fatty acid methyl esters. 2012 Analyst pmid:22166918
Zhen Z and Xie J Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging. 2012 Theranostics pmid:22272218
Imae R et al. LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. 2012 J. Lipid Res. pmid:22172515
Becker S et al. Optimization of hepatocarcinoma uptake with radiolabeled lipiodol: development of new lipiodol formulations with increased viscosity. 2012 Cancer Biother. Radiopharm. pmid:22149684
Stryjecki C et al. Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation. 2012 Mol. Genet. Metab. pmid:22209225
Casiraghi A et al. The influence of the polar head and the hydrophobic chain on the skin penetration enhancement effect of poly(ethylene glycol) derivatives. 2012 AAPS PharmSciTech pmid:22232021
Wei CC and Ge ZQ Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs). 2012 Drug Dev Ind Pharm pmid:22181005
Singh AV and Nath LK Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery. 2012 Int. J. Biol. Macromol. pmid:22210486
Streit MR et al. High survival in young patients using a second generation uncemented total hip replacement. 2012 Int Orthop pmid:22113735
Pijls BG et al. Polyethylene thickness is a risk factor for wear necessitating insert exchange. 2012 Int Orthop pmid:22105569
Chapple IL et al. Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. 2012 J. Clin. Periodontol. pmid:22093005
Reddy KR et al. Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. 2012 Clin Trials pmid:22058086
Ruiz M et al. A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. 2012 PLoS ONE pmid:23056435
Imarisio C et al. Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. 2012 Clin. Sci. pmid:22439844
Rojas J and Kumar V Effect of silicification on the tableting performance of cellulose ii: a novel multifunctional excipient. 2012 Chem. Pharm. Bull. pmid:22689398
Griffith EC et al. Hydrophobic collapse of a stearic acid film by adsorbed l-phenylalanine at the air-water interface. 2012 J Phys Chem B pmid:22691061
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Mekhail GM et al. Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan. 2012 Int. J. Biol. Macromol. pmid:22652220
Feugmo CG et al. Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces. 2012 J Phys Condens Matter pmid:22394578
Watanabe Y et al. The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. 2012 Diabetes pmid:22396206
Choi du H et al. A new experimental design method to optimize formulations focusing on a lubricant for hydrophilic matrix tablets. 2012 Drug Dev Ind Pharm pmid:22348254
Kim DH et al. Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function. 2012 Colloids Surf B Biointerfaces pmid:22361356
Honkanen AM et al. Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. 2012 J. Dairy Sci. pmid:22365221
Kushner J Incorporating Turbula mixers into a blending scale-up model for evaluating the effect of magnesium stearate on tablet tensile strength and bulk specific volume. 2012 Int J Pharm pmid:22405966
Matsui H et al. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. 2012 PLoS ONE pmid:22413010
Trupp M et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. 2012 PLoS ONE pmid:22808006
Kang JH et al. Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). 2012 Eur J Pharm Biopharm pmid:22119666
Schreiber R et al. Retinyl ester hydrolases and their roles in vitamin A homeostasis. 2012 Biochim. Biophys. Acta pmid:21586336
Bonaduce I et al. New insights into the ageing of linseed oil paint binder: a qualitative and quantitative analytical study. 2012 PLoS ONE pmid:23166642
Kurotani K et al. High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. 2012 Nutr Res pmid:23084639
Akinsete JA et al. Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice. 2012 Carcinogenesis pmid:22045025
Simmons DM and Gierer DS A material sparing test to predict punch sticking during formulation development. 2012 Drug Dev Ind Pharm pmid:22181042
Niu J et al. Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery. 2012 Eur J Pharm Sci pmid:22119655
Jung HA and Augsburger LL Application of a novel automatic disintegration apparatus for the development and evaluation of a direct compression rapidly disintegrating tablet. 2012 Drug Dev Ind Pharm pmid:22091970
Weiss VM et al. Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. 2012 J Control Release pmid:21971295
Tuli RA et al. Polycaprolactone microspheres as carriers for dry powder inhalers: effect of surface coating on aerosolization of salbutamol sulfate. 2012 J Pharm Sci pmid:21956254
Shuhendler AJ et al. Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry. 2012 J Control Release pmid:21939700
Tokudome Y and Otsuka M Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. 2012 Biol. Pharm. Bull. pmid:22975500
Aissa I et al. Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities. 2012 Lipids Health Dis pmid:22264330
Lu J et al. A molecular mechanism for modulating plasma Zn speciation by fatty acids. 2012 J. Am. Chem. Soc. pmid:22239162
Wang Z et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling. 2012 Br. J. Nutr. pmid:21733316
Nesarikar VV et al. Instrumented roll technology for the design space development of roller compaction process. 2012 Int J Pharm pmid:22286023
Masuda M et al. Activating transcription factor 4 regulates stearate-induced vascular calcification. 2012 J. Lipid Res. pmid:22628618
Toubiana D et al. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. 2012 PLoS Genet. pmid:22479206
Eili M et al. Degradability enhancement of poly(lactic acid) by stearate-Zn(3)Al LDH nanolayers. 2012 Int J Mol Sci pmid:22942682
Hayashi Y et al. Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet. 2012 Chem. Pharm. Bull. pmid:22878814
Tamokou Jde D et al. Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). 2012 BMC Complement Altern Med pmid:22809287
Slobodkina GB et al. Deferrisoma camini gen. nov., sp. nov., a moderately thermophilic, dissimilatory iron(III)-reducing bacterium from a deep-sea hydrothermal vent that forms a distinct phylogenetic branch in the Deltaproteobacteria. 2012 Int. J. Syst. Evol. Microbiol. pmid:22140176
Meka VS et al. Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl. 2012 Invest Clin pmid:22524109
Lalloo AK et al. Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model. 2012 Int J Pharm pmid:22546295
Chakradhar RP and Dinesh Kumar V Water-repellent coatings prepared by modification of ZnO nanoparticles. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22575349
Agostini F et al. Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. 2012 ScientificWorldJournal pmid:22593706
Guillon A et al. Pulmonary delivery of dry powders to rats: tolerability limits of an intra-tracheal administration model. 2012 Int J Pharm pmid:22609125
Schrank S et al. Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. 2012 AAPS PharmSciTech pmid:22552931
Loutelier-Bourhis C et al. Mechanistic study of maleic anhydride grafting onto fatty double bonds using mass spectrometry. 2012 Rapid Commun. Mass Spectrom. pmid:22555920