stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Ferrari F et al. The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. 2004 AAPS PharmSciTech pmid:15760057
Missaghi S and Fassihi R A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. 2004 AAPS PharmSciTech pmid:15760087
Watanabe L et al. Structural insights for fatty acid binding in a Lys49-phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid. 2005 Biochimie pmid:15760708
Schreiner T et al. Immediate drug release from solid oral dosage forms. 2005 J Pharm Sci pmid:15761936
Risé P et al. Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines. 2005 Biochem. Pharmacol. pmid:15763545
Coscione AR and Artz WE Vegetable oil stability at elevated temperatures in the presence of ferric stearate and ferrous octanoate. 2005 J. Agric. Food Chem. pmid:15769140
Garg M et al. Hepatic de novo lipogenesis in stable low-birth-weight infants during exclusive breast milk feedings and during parenteral nutrition. JPEN J Parenter Enteral Nutr pmid:15772384
Aoshima H et al. Glycerin fatty acid esters as a new lubricant of tablets. 2005 Int J Pharm pmid:15778041
Fujii M et al. Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone. 2005 Int J Pharm pmid:15778052
Egerton TA et al. Characterization of TiO2 nanoparticles surface modified with aluminum stearate. 2005 Langmuir pmid:15780001
Geslin JM et al. [Allergic respiratory disorders and vein sclerosis with lauromacrogol 400]. Therapie pmid:15789831
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--saponification reaction and saponification value]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15806965
Savickas A and Bernatoniene J Optimization of "Askoeziuofito" tablets. 2005 Medicina (Kaunas) pmid:15827390
Fabianowski W et al. Integrated circuits protection with the Langmuir-Blodgett Films. 2005 Bioelectrochemistry pmid:15833702
Shim SK et al. Analysis of cellular fatty acids in Orientia tsutsugamushi as taxonomic markers. 2005 Microbiol. Immunol. pmid:15840959
Menéndez R et al. In vitro and in vivo study of octacosanol metabolism. 2005 Mar-Apr Arch. Med. Res. pmid:15847942
Li W and Worosila GD Quantitation of active pharmaceutical ingredients and excipients in powder blends using designed multivariate calibration models by near-infrared spectroscopy. 2005 Int J Pharm pmid:15848006
Adams M and Kwon GS Spectroscopic investigation of the aggregation state of amphotericin B during loading, freeze-drying, and reconstitution of polymeric micelles. 2004 J Pharm Pharm Sci pmid:15850542
Scaglia N and Igal RA Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. 2005 J. Biol. Chem. pmid:15851470
Ibáñez L et al. Population-based drug-induced agranulocytosis. 2005 Arch. Intern. Med. pmid:15851637
Katsuta Y et al. Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. 2005 J. Invest. Dermatol. pmid:15854043
Tomassetti M et al. Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures. 2005 J Pharm Biomed Anal pmid:15862672
Salzman RA et al. Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses. 2005 Plant Physiol. pmid:15863699
Hosaka S et al. Effect of compression on interaction between 1,4-dihydropyridine compounds and lactose monohydrate. 2005 Chem. Pharm. Bull. pmid:15863920
Harris RK et al. Quantification of bambuterol hydrochloride in a formulated product using solid-state NMR. 2005 J Pharm Biomed Anal pmid:15869858
Vanholder T et al. Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. 2005 Anim. Reprod. Sci. pmid:15885439
Yagi T et al. Lymphatic absorption of structured triacylglycerols, 1(3)-stearoyl-2,3 (1)-dilinoleoylglycerol and 2-linoleoyl-1,3-distearoylglycerol in rats. 2004 J. Nutr. Sci. Vitaminol. pmid:15895523
Jurkiewicz K Adsorptive bubble separation of zinc and cadmium cations in presence of ferric and aluminum hydroxides. 2005 J Colloid Interface Sci pmid:15897071
Choi MY et al. Pheromone biosynthetic pathways in the moths Heliothis subflexa and Heliothis virescens. 2005 Arch. Insect Biochem. Physiol. pmid:15898118
Green RL et al. Comparison of near-infrared and laser-induced breakdown spectroscopy for determination of magnesium stearate in pharmaceutical powders and solid dosage forms. 2005 Appl Spectrosc pmid:15901316
Donoso M and Ghaly ES Prediction of tablets disintegration times using near-infrared diffuse reflectance spectroscopy as a nondestructive method. 2005 Pharm Dev Technol pmid:15926669
Mirmehrabi M and Rohani S An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals. 2005 J Pharm Sci pmid:15929066
Patil S and Chan C Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. 2005 Neurosci. Lett. pmid:15939536
Grabowski A et al. Characterization of long-chain fatty-acid-degrading syntrophic associations from a biodegraded oil reservoir. 2005 Res. Microbiol. pmid:15939576
Muzíková J and Páleník L [A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose]. 2005 Ceska Slov Farm pmid:15945458
Mitra A et al. Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. 1992 Toxicol. Lett. pmid:1595087
Berry SE and Sanders TA Influence of triacylglycerol structure of stearic acid-rich fats on postprandial lipaemia. 2005 Proc Nutr Soc pmid:15960865
Barkai G et al. Community prescribing and resistant Streptococcus pneumoniae. 2005 Emerging Infect. Dis. pmid:15963276
Verma RK and Garg S Selection of excipients for extended release formulations of glipizide through drug-excipient compatibility testing. 2005 J Pharm Biomed Anal pmid:15967291
Lin WC et al. Determination of carotenoids in spear shrimp shells (Parapenaeopsis hardwickii) by liquid chromatography. 2005 J. Agric. Food Chem. pmid:15969489
Fernández-Moya V et al. Oils from improved high stearic acid sunflower seeds. 2005 J. Agric. Food Chem. pmid:15969513
Vanholder T et al. Effect of non-esterified fatty acids on bovine theca cell steroidogenesis and proliferation in vitro. 2006 Anim. Reprod. Sci. pmid:15978752
Shibata Y et al. Evaluation of the compaction properties of a solid dispersion of indomethacin with crospovidone by tableting process analyzer. 2005 Chem. Pharm. Bull. pmid:15997130
Sahin N et al. Lipase-catalyzed acidolysis of tripalmitin with hazelnut oil fatty acids and stearic acid to produce human milk fat substitutes. 2005 J. Agric. Food Chem. pmid:15998148
Jiang RG et al. [Effect of surface modification on surface energy of lactose and performance of dry powder inhalations]. 2005 Yao Xue Xue Bao pmid:16011271
Zhao XY et al. [Studies on chemical constituents from rhizome of Impatiens pritzellii var. hupehensis]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011279
Tappia PS et al. Phospholipid profile of developing heart of rats exposed to low-protein diet in pregnancy. 2005 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16020521
Morais S et al. Dietary protein:lipid ratio and lipid nature affects fatty acid absorption and metabolism in a teleost larva. 2005 Br. J. Nutr. pmid:16022750
Serrano-Vega MJ et al. Lipid characterization of seed oils from high-palmitic, low-palmitoleic, and very high-stearic acid sunflower lines. 2005 Lipids pmid:16028719
Mungur R et al. Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. 2005 J. Biomed. Biotechnol. pmid:16046826
Staiger K et al. Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells. 2005 Diabetologia pmid:16078017
Dennis M and Kolattukudy PE A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1608940
el-Naghy MA et al. Fungistatic action of natural oils and fatty acids on dermatophytic and saprophytic fungi. 1992 Zentralbl. Mikrobiol. pmid:1609554
Armoni M et al. Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements. 2005 J. Biol. Chem. pmid:16096283
Wang X et al. Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole. 2005 Int J Pharm pmid:16105723
Li D et al. Plasma coagulation factor VII activity and its correlates in healthy men. 2005 Eur J Clin Nutr pmid:16106263
St-Onge L et al. Rapid quantitative analysis of magnesium stearate in tablets using laser-induced breakdown spectroscopy. 2005 J Pharm Pharm Sci pmid:16124938
Guo LJ et al. [The structure and properties of self-assembly complex LB films of silver nanoparticles]. 2005 Guang Pu Xue Yu Guang Pu Fen Xi pmid:16128074
Hoppu U et al. Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant. 2005 J. Pediatr. Gastroenterol. Nutr. pmid:16131990
Staiger H et al. Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. 2005 Diabetologia pmid:16132959
Parra-Barraza H et al. Chitosan-cholesterol and chitosan-stearic acid interactions at the air-water interface. 2005 Sep-Oct Biomacromolecules pmid:16153076
Gelders GG et al. Potato phosphorylase catalyzed synthesis of amylose-lipid complexes. 2005 Sep-Oct Biomacromolecules pmid:16153100
Hong J et al. The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro. 2005 Metab. Clin. Exp. pmid:16154432
Thijssen MA and Mensink RP Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. 2005 Am. J. Clin. Nutr. pmid:16155261
Chen Y et al. Side reactions in controlling the quality, yield, and stability of high quality colloidal nanocrystals. 2005 J. Am. Chem. Soc. pmid:16173766
Turkoglu M et al. Evaluation of hexagonal boron nitride as a new tablet lubricant. 2005 Pharm Dev Technol pmid:16176018
Rao KP et al. Impact of solid-state properties on lubrication efficacy of magnesium stearate. 2005 Pharm Dev Technol pmid:16176023
Leroy JL et al. Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. 2005 Reproduction pmid:16183866
Dentin R et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. 2005 J. Clin. Invest. pmid:16184193
Stanisz B The influence of pharmaceutical excipients on quinapril hydrochloride stability. 2005 May-Jun Acta Pol Pharm pmid:16193811
Kiuru PS and Wähälä K Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters. 2006 Steroids pmid:16198386
Vueba ML et al. Role of cellulose ether polymers on ibuprofen release from matrix tablets. 2005 Drug Dev Ind Pharm pmid:16207613
Jonat S et al. Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. 2005 Drug Dev Ind Pharm pmid:16207616
Zeman M et al. N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. 2006 J. Nutr. Biochem. pmid:16214329
Terán M et al. Hydrophilic and lipophilic radiopharmaceuticals as tracers in pharmaceutical development: in vitro--in vivo studies. 2005 BMC Nucl Med pmid:16232323
Nohynek GJ et al. Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. 2006 Toxicol. Lett. pmid:16243460
Lee J Intrinsic adhesion properties of poly(vinyl pyrrolidone) to pharmaceutical materials: humidity effect. 2005 Macromol Biosci pmid:16245267
Bajaj M et al. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. 2005 Diabetes pmid:16249438
Choi HJ et al. Structure and thermal behavior of a layered silver hydroxyalkanecarboxylate. 2003 J Colloid Interface Sci pmid:16256665
Lad MD et al. Protein-lipid interactions at the air/water interface. 2005 Phys Chem Chem Phys pmid:16273149
Chiang EP et al. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. 2005 Arthritis Res. Ther. pmid:16277693
Segre N et al. Surface characterization of recycled tire rubber to be used in cement paste matrix. 2002 J Colloid Interface Sci pmid:16290558
Garcia Marquez MA et al. [The effect of two lubricants (magnesium stearate and pruv) in the formation of tablets of four anti-ulcer agents/ by means of direct compression]. 1992 Pharm Acta Helv pmid:1631172
Jahn T and Steffens KJ Press chamber coating as external lubrication for high speed rotary presses: lubricant spray rate optimization. 2005 Drug Dev Ind Pharm pmid:16316850
Thijssen MA et al. Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. 2005 J. Nutr. pmid:16317124
Mayer KM et al. Linking enzyme sequence to function using Conserved Property Difference Locator to identify and annotate positions likely to control specific functionality. 2005 BMC Bioinformatics pmid:16318626
Garton NJ and Sutcliffe IC Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis. 2006 Arch. Microbiol. pmid:16320036
Fukami J et al. Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy. 2005 Chem. Pharm. Bull. pmid:16327184
Bonanome A et al. Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. 1992 Atherosclerosis pmid:1632865
Wang L et al. [Synthesis, characterization and evaluation of octadecyl ester-bonded monolithic column]. 2005 Se Pu pmid:16350795
Tatavarti AS et al. Assessment of NIR spectroscopy for nondestructive analysis of physical and chemical attributes of sulfamethazine bolus dosage forms. 2005 AAPS PharmSciTech pmid:16353969
Soares LA et al. Dry granulation and compression of spray-dried plant extracts. 2005 AAPS PharmSciTech pmid:16353993
Navaneethan CV et al. Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. 2005 AAPS PharmSciTech pmid:16353997
Pérez-Vich B et al. Molecular analysis of the high stearic acid content in sunflower mutant CAS-14. 2006 Theor. Appl. Genet. pmid:16362273
Wurster DE et al. The influence of magnesium stearate on the Hiestand Tableting Indices and other related mechanical properties of maltodextrins. 2005 Pharm Dev Technol pmid:16370175
Wyttenbach N et al. Drug-excipient compatibility testing using a high-throughput approach and statistical design. 2005 Pharm Dev Technol pmid:16370179
Pirozhkov SV et al. Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. 1992 Jul-Aug Alcohol pmid:1637499
Demirbas A et al. Adsorption thermodynamics of stearic acid onto bentonite. 2006 J. Hazard. Mater. pmid:16386845
Ding EL et al. Chocolate and prevention of cardiovascular disease: a systematic review. 2006 Nutr Metab (Lond) pmid:16390538
Douliez JP et al. Self-assembly of fatty acid-alkylboladiamine salts. 2006 Langmuir pmid:16401110