MeSH term | MeSH ID | Detail |
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Obesity, Abdominal | D056128 | 3 associated lipids |
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wieland SJ et al. | Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids. | 1992 | Am. J. Physiol. | pmid:1514578 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Michiels C et al. | Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. | 1993 | Am. J. Physiol. | pmid:8476019 |
Hart CM et al. | Supplemental fatty acids alter lipid peroxidation and oxidant injury in endothelial cells. | 1991 | Am. J. Physiol. | pmid:2058691 |
Lee WN et al. | Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. | 1994 | Am. J. Physiol. | pmid:8166257 |
Zoukhri D and Dartt DA | Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. | 1995 | Am. J. Physiol. | pmid:7900776 |
Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
Burt JM et al. | Uncoupling of cardiac cells by fatty acids: structure-activity relationships. | 1991 | Am. J. Physiol. | pmid:2003571 |
Lee WN et al. | In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. | 1994 | Am. J. Physiol. | pmid:8203508 |