MeSH term | MeSH ID | Detail |
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Decalcification, Pathologic | D003649 | 1 associated lipids |
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dougherty RM et al. | Effects of diets containing high or low amounts of stearic acid on plasma lipoprotein fractions and fecal fatty acid excretion of men. | 1995 | Am. J. Clin. Nutr. | pmid:7733038 |
Yu S et al. | Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. | 1995 | Am. J. Clin. Nutr. | pmid:7733039 |
Connor WE | Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content? | 1999 | Am. J. Clin. Nutr. | pmid:10584037 |
Crowe FL et al. | Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. | 2008 | Am. J. Clin. Nutr. | pmid:18996872 |
Watts GF et al. | Dietary fatty acids and progression of coronary artery disease in men. | 1996 | Am. J. Clin. Nutr. | pmid:8694021 |
Sanders TA et al. | Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats. | 2003 | Am. J. Clin. Nutr. | pmid:12663272 |
Heude B et al. | Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663275 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Tholstrup T et al. | Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men. | 1996 | Am. J. Clin. Nutr. | pmid:8694016 |
Ma W et al. | Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. | 2015 | Am. J. Clin. Nutr. | pmid:25527759 |