stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypothyroidism D007037 32 associated lipids
Melanoma D008545 69 associated lipids
Occupational Diseases D009784 42 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Bos CE et al. Native starch in tablet formulations: properties on compaction. 1987 Pharm Weekbl Sci pmid:3432037
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Hasin Y et al. Dietary lipid intake and myocardial electrophysiology. 1987 Isr. J. Med. Sci. pmid:3440741
Cutler RR et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. 1987 Tubercle pmid:3448797
Peura P et al. The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. 1986 Arch. Toxicol. Suppl. pmid:3468932
Matsui MS and Jeffrey AM Fatty acid modification of C3H 10T 1/2 fibroblast cells: changes in benzo(a)pyrene metabolism and phorbol ester binding. 1987 Cancer Res. pmid:3471326
Pajor L et al. Microsomal desaturation of stearic acid in relation to lymphocyte activation. 1986 Arch. Biochem. Biophys. pmid:3485399
Ras GJ and Anderson R An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. 1986 J. Antimicrob. Chemother. pmid:3486178
Albertini G et al. Studies of structural modifications induced by gamma-irradiation in distearoylphosphatidylcholine liposomes. 1987 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. pmid:3496306
Carter BL et al. Gastrointestinal side effects with erythromycin preparations. 1987 Drug Intell Clin Pharm pmid:3498618
Goto S et al. Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen. 1986 Oct-Dec J Microencapsul pmid:3508190
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Slomiany BL et al. Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. 1986 Biochim. Biophys. Acta pmid:3518803
Muñoz-Espin T et al. Erythromycin versus tetracycline for treatment of Mediterranean spotted fever. 1986 Arch. Dis. Child. pmid:3535687
McCormack WM et al. Effect on birth weight of erythromycin treatment of pregnant women. 1987 Obstet Gynecol pmid:3543767
Bridges CD et al. Rhodopsin, vitamin A, and interstitial retinol-binding protein in the rd chicken. 1987 Invest. Ophthalmol. Vis. Sci. pmid:3557867
Hope MJ and Cullis PR Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. 1987 J. Biol. Chem. pmid:3558410
Habib NA et al. Desaturation-producing factor present in the tissue, blood, and urine of cancer patients. 1987 Cancer Detect. Prev. pmid:3568009
Wang ST et al. A comparison of fatty acid composition of cholesteryl esters in subjects at various concentrations of serum lipid. 1987 Clin. Biochem. pmid:3568345
Pospísilová B and Kubes J [Stability of erythromycin stearate in coated tablets during the action of gastric juice in vitro]. 1987 Cesk Farm pmid:3581192
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Kolesnick RN and Paley AE 1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action. 1987 J. Biol. Chem. pmid:3597411
Habib NA et al. Increased erythrocyte stearic acid desaturation in rats with chemically induced colorectal carcinomas. 1987 Int J Colorectal Dis pmid:3598325
Husebye ES and Flatmark T Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla. 1987 Biochim. Biophys. Acta pmid:3607074
Cavalleri A and Minoia C Lead level of whole blood and plasma in workers exposed to lead stearate. 1987 Scand J Work Environ Health pmid:3616550
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Pyörälä S Effect of some vehicles used in intramammary mastitis preparations on inflammation indicators in milk. 1987 J. Vet. Pharmacol. Ther. pmid:3656512
Worman CP et al. Saturation index of blood cell membrane fatty acids before and after IFN treatment in hairy cell leukemia. 1987 Leukemia pmid:3669764
Mäntylä R et al. Bioavailability and effect of food on the gastrointestinal absorption of two erythromycin derivatives. 1978 Ann. Clin. Res. pmid:367255
Caglayan S et al. Is medical therapy effective for regional lymphadenitis following BCG vaccination? 1987 Am. J. Dis. Child. pmid:3673975
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Venho VM et al. The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. 1987 Methods Find Exp Clin Pharmacol pmid:3683018
Habib NA et al. Stearic acid and carcinogenesis. 1987 Br. J. Cancer pmid:3689663
Kaya K and Nohara K Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena. 1987 Chem. Biol. Interact. pmid:3690725
Goto S et al. [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. 1986 Yakugaku Zasshi pmid:3701600
Shah KB et al. An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. 1986 J Pharm Sci pmid:3701614
Okabe H et al. Effects of anti-convulsants on fatty acid metabolism in human serum. 1986 Tohoku J. Exp. Med. pmid:3705068
Thompson W and Belina H Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. 1986 Biochim. Biophys. Acta pmid:3707975
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Caponnetto A et al. [Correlations between unsaturated fatty acids and medium C-chain triglycerides]. 1986 Boll. Soc. Ital. Biol. Sper. pmid:3718739
Beaumelle BD and Vial HJ Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. 1986 Biochim. Biophys. Acta pmid:3719005
Chalupa W et al. Ruminal fermentation in vivo as influenced by long-chain fatty acids. 1986 J. Dairy Sci. pmid:3722545
Wan LS and Choong YL The effect of excipients on the penetration of liquid into tablets. 1986 Pharm Acta Helv pmid:3725815
Oh-Hashi Y et al. Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. 1986 Arch. Biochem. Biophys. pmid:3729431
Carter-Dawson L et al. Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. 1986 Dev. Biol. pmid:3732615
Chowhan ZT and Chi LH Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution. 1986 J Pharm Sci pmid:3735096
Chowhan ZT and Chi LH Drug-excipient interactions resulting from powder mixing. IV: Role of lubricants and their effect on in vitro dissolution. 1986 J Pharm Sci pmid:3735097
Fujii T et al. Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. 1986 Biochem. Int. pmid:3741447
Chester DW et al. The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. 1986 Biochim. Biophys. Acta pmid:3741857