stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypothyroidism D007037 32 associated lipids
Melanoma D008545 69 associated lipids
Occupational Diseases D009784 42 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Tadros MI and Fahmy RH Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. 2014 Int J Pharm pmid:24928130
Evoli S et al. Molecular simulations of β-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites. 2014 Proteins pmid:24916607
Loften JR et al. Invited review: palmitic and stearic acid metabolism in lactating dairy cows. 2014 J. Dairy Sci. pmid:24913651
Uğurlu T and Halaçoğlu MD Effects of some lubricants and evaluation of compression parameters on directly compressible powders. 2014 Pharm Dev Technol pmid:23590449
Chen FY et al. TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. 2014 Int J Nanomedicine pmid:25298734
Saerens L et al. Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion. 2014 Anal. Chim. Acta pmid:24331054
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Aljaberi A et al. Understanding and optimizing the dual excipient functionality of sodium lauryl sulfate in tablet formulation of poorly water soluble drug: wetting and lubrication. 2013 Mar-Apr Pharm Dev Technol pmid:23009028
Kushner J Utilizing quantitative certificate of analysis data to assess the amount of excipient lot-to-lot variability sampled during drug product development. 2013 Mar-Apr Pharm Dev Technol pmid:21877870
Hussain T et al. Effect of two hydrophobic polymers on the release of gliclazide from their matrix tablets. 2013 Jul-Aug Acta Pol Pharm pmid:23923399
Muzíková J and Sináglová P Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses. 2013 Jan-Feb Acta Pol Pharm pmid:23610968
Dawes J et al. Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations. 2013 Pharm Dev Technol pmid:22813432
Stanisz B et al. Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations. 2013 Drug Dev Ind Pharm pmid:22348774
Mazel V et al. The surface layer of pharmaceutical compacts: the role of the punch surface and its impact on the mechanical properties of the compacts. 2013 Int J Pharm pmid:22902389
Intorre F et al. Fatty acid content of serum lipid fractions and blood lipids in normolipidaemic volunteers fed two types of cheese having different fat compositions: a pilot study. 2013 Int J Food Sci Nutr pmid:22849318
Vitturi DA et al. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. 2013 J. Biol. Chem. pmid:23878198
Saeedi Vahdat A et al. Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. 2013 Int J Pharm pmid:23820132
Li L et al. Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film. 2013 Int J Pharm pmid:23624081
Neutsch L et al. UPEC biomimickry at the urothelial barrier: lectin-functionalized PLGA microparticles for improved intravesical chemotherapy. 2013 Int J Pharm pmid:23628404
Emken E Human studies using isotope labeled fatty acids: answered and unanswered questions. 2013 J Oleo Sci pmid:23648399
Dangarembizi R et al. Aloe ferox seed: a potential source of oil for cosmetic and pharmaceutical use. 2013 Nat Prod Commun pmid:23678824
Maia M et al. A novel, direct, reagent-free method for the detection of beeswax adulteration by single-reflection attenuated total reflectance mid-infrared spectroscopy. 2013 Talanta pmid:23598195
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Salehi M et al. Debinding mechanisms in thermoplastic processing of a Ba(0.5)Sr(0.5)Co(0.8)Fe(0.2)O(3-δ)- stearic acid-polystyrene mixture. 2013 ChemSusChem pmid:23281298
He M et al. Controllable stearic acid crystal induced high hydrophobicity on cellulose film surface. 2013 ACS Appl Mater Interfaces pmid:23289586
Wan Q et al. Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery. 2013 Nanoscale pmid:23224057
Nakagawa H et al. Real-time monitoring of lubrication properties of magnesium stearate using NIR spectrometer and thermal effusivity sensor. 2013 Int J Pharm pmid:23174413
Otsuka Y et al. Effects of polymorphic transformation on pharmaceutical properties of direct compressed tablets containing theophylline anhydrate bulk powder under high humidity. 2013 Colloids Surf B Biointerfaces pmid:23178204
Azordegan N et al. Carcinogenesis alters fatty acid profile in breast tissue. 2013 Mol. Cell. Biochem. pmid:23180247
Delbecq F et al. N-stearoyl amino acid derivatives: potent biomimetic hydro/organogelators as templates for preparation of gold nanoparticles. 2013 J Colloid Interface Sci pmid:23089597
John CT et al. Formulating weakly basic HCl salts: relative ability of common excipients to induce disproportionation and the unique deleterious effects of magnesium stearate. 2013 Pharm. Res. pmid:23512680
Stank K and Steckel H Physico-chemical characterisation of surface modified particles for inhalation. 2013 Int J Pharm pmid:23518364
Kumar N et al. Salt dependent stability of stearic acid Langmuir-Blodgett films exposed to aqueous electrolytes. 2013 Langmuir pmid:23565719
Han SH et al. Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices. 2013 Biomacromolecules pmid:23550841
Khan AA et al. Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. 2013 Anticancer Res. pmid:23749903
Li C et al. Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. 2013 Sci Rep pmid:23712069
Lakio S et al. Challenges in detecting magnesium stearate distribution in tablets. 2013 AAPS PharmSciTech pmid:23378252
Järvinen MA et al. Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. 2013 Drug Dev Ind Pharm pmid:23163644
Schrank S et al. Microstructure of calcium stearate matrix pellets: a function of the drying process. 2013 J Pharm Sci pmid:23983150
Yang C et al. Production of aviation fuel via catalytic hydrothermal decarboxylation of fatty acids in microalgae oil. 2013 Bioresour. Technol. pmid:23973977
Jin Q et al. A novel cationic microbubble coated with stearic acid-modified polyethylenimine to enhance DNA loading and gene delivery by ultrasound. 2013 PLoS ONE pmid:24086748
Eltayeb M et al. Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery. 2013 Nanotechnology pmid:24164775
Boshtam M et al. Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein. 2013 Dis. Markers pmid:24167374
Shibata E et al. Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. 2013 Cell. Physiol. Biochem. pmid:24107614
Zhang W et al. Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. 2013 Bioconjug. Chem. pmid:24107137
Michailidou VN et al. Anisotropic diffusion of concentrated hard-sphere colloids near a hard wall studied by evanescent wave dynamic light scattering. 2013 J Chem Phys pmid:24182077
Hosseini A et al. Direct compression of cushion-layered ethyl cellulose-coated extended release pellets into rapidly disintegrating tablets without changes in the release profile. 2013 Int J Pharm pmid:23892153
Neupane YR et al. Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. 2013 Nanotechnology pmid:24061410
Yan J et al. Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. 2013 Mol. Pharm. pmid:23679858
Kwan HY et al. The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. 2013 J. Gastroenterol. pmid:22722903