stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Kumar Gaur P et al. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. 2016 Artif Cells Nanomed Biotechnol pmid:26375758
Li X et al. Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. 2016 Drug Dev Ind Pharm pmid:26289006
Uğurlu T and Halaçoğlu MD Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500. 2016 Pharm Dev Technol pmid:25716058
Jójárt I et al. Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. 2016 Pharm Dev Technol pmid:25673279
Patadia R et al. Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets. 2016 Pharm Dev Technol pmid:25566928
Pradhan M et al. Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. 2016 Artif Cells Nanomed Biotechnol pmid:25229831
Yin L et al. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. 2016 Toxicol In Vitro pmid:26820058
Guan Q et al. Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation. 2016 Molecules pmid:27918445
Shur J et al. From single excipients to dual excipient platforms in dry powder inhaler products. 2016 Int J Pharm pmid:27262269
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Kanasaki Y et al. Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. 2016 J Oleo Sci pmid:27725481
Souza AF et al. Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. 2016 Int J Mol Sci pmid:27669227
Teh SS et al. Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification. 2016 J Oleo Sci pmid:27477075
Simon C et al. Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. 2016 Toxicol In Vitro pmid:27633901
Sun Y et al. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. 2016 J. Lipid Res. pmid:27371261
Du H et al. Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene. 2016 BMC Plant Biol. pmid:27297560
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
Jeyanathan J et al. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. 2016 BMC Microbiol. pmid:27283157
Shah RM et al. Microwave-assisted formulation of solid lipid nanoparticles loaded with non-steroidal anti-inflammatory drugs. 2016 Int J Pharm pmid:27789371
Abreu P et al. Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. 2016 Exp. Physiol. pmid:27579497
Garba L et al. Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. 2016 Mol. Biotechnol. pmid:27629791
Mazel V et al. Reevaluation of the diametral compression test for tablets using the flattened disc geometry. 2016 Int J Pharm pmid:27702696
Nie H et al. Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. 2016 Mol. Pharm. pmid:27542728
Schrank S et al. Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. 2016 Int J Pharm pmid:27282540
Eltayeb M et al. Electrosprayed nanoparticle delivery system for controlled release. 2016 Mater Sci Eng C Mater Biol Appl pmid:27207047
Hu Y et al. Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier. 2016 Oncotarget pmid:27825127
Zhao H et al. Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. 2016 Phys Chem Chem Phys pmid:27170421
Billès E et al. Cellulose oligomers production and separation for the synthesis of new fully bio-based amphiphilic compounds. 2016 Carbohydr Polym pmid:27577903
Afonso MS et al. Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. 2016 J. Nutr. Biochem. pmid:27142741
Krasnou I et al. Permeability of water and oleic acid in composite films of phase separated polypropylene and cellulose stearate blends. 2016 Carbohydr Polym pmid:27516292
Haware RV et al. Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. 2016 Eur J Pharm Sci pmid:27108117
Liu L et al. Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. 2016 Eur J Clin Nutr pmid:26733041
Wang HJ et al. Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. 2016 J Mater Sci Mater Med pmid:26979976
Cheng CL et al. Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. 2016 Dig Liver Dis pmid:26976784
Moazeni M et al. Time to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. 2016 Colloids Surf B Biointerfaces pmid:26974361
Lu H et al. Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. 2016 Diabetologia pmid:26969487
Thilakarathna SH et al. Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. 2016 Food Funct pmid:26961726
Ma F et al. Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. 2016 Mater Sci Eng C Mater Biol Appl pmid:26952440
Zhang C et al. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. 2016 Int J Pharm pmid:26943975
Zhang Y et al. CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. 2016 Langmuir pmid:26907546
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Lohan SB et al. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers. 2016 Int J Pharm pmid:26853315
Qu L et al. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. 2015 Eur J Pharm Sci pmid:26215464
Hong J et al. Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition. 2015 Meat Sci. pmid:26172243
Park JH et al. Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. 2015 Int J Pharm pmid:26149935
Vercruysse J et al. Use of a continuous twin screw granulation and drying system during formulation development and process optimization. 2015 Eur J Pharm Biopharm pmid:25528462
Schrank S et al. The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. 2015 Int J Pharm pmid:25526671
Foraita S et al. Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. 2015 Chemistry pmid:25504844
Yan S et al. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. 2015 Fungal Genet. Biol. pmid:25498164
Qu L et al. Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015 Drug Dev Ind Pharm pmid:24738790