stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
Prostatic Diseases D011469 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Insulin Resistance D007333 99 associated lipids
Obesity, Abdominal D056128 3 associated lipids
Rosacea D012393 13 associated lipids
Amnesia D000647 12 associated lipids
Gonorrhea D006069 7 associated lipids
Calculi D002137 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Narayanan VS and Storch J Fatty acid transfer in taurodeoxycholate mixed micelles. 1996 Biochemistry pmid:8652524
Noy N and Zakim D Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase. 1985 Biochemistry pmid:2931113
Rich MR and Evans JS Molecular dynamics simulations of adipocyte lipid-binding protein: effect of electrostatics and acyl chain unsaturation. 1996 Biochemistry pmid:8634281
Negash S et al. Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. 1996 Biochemistry pmid:8784178
Huber AH et al. Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin. 2006 Biochemistry pmid:17128966
Wu F and Gaffney BJ Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. 2006 Biochemistry pmid:17029406
Hamilton KS et al. Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. 1993 Biochemistry pmid:8471610
Zornetzer GA et al. The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. 2010 Biochemistry pmid:20014832
Richieri GV et al. Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. 2000 Biochemistry pmid:10852718
Mantipragada SB et al. Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. 2003 Biochemistry pmid:12885251
Huang G et al. Identification of the thiol ester linked lipids in apolipoprotein B. 1988 Biochemistry pmid:3365394
Perkins RC et al. Equilibrium binding of spin-labeled fatty acids to bovine serum albumin: suitability as surrogate ligands for natural fatty acids. 1982 Biochemistry pmid:6289869
Feix JB et al. An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. 1984 Biochemistry pmid:6329270
Murate M et al. Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. 2010 Biochemistry pmid:20433166
Pohl J et al. Long-chain fatty acid uptake into adipocytes depends on lipid raft function. 2004 Biochemistry pmid:15065861
Woodward H et al. Isolation, purification, and properties of respiratory mucus glycoproteins. 1982 Biochemistry pmid:7074033
Smaby JM and Brockman HL Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups. 1981 Biochemistry pmid:7213606
Chen SC et al. Calorimetric evidence for phase transitions in spin-label lipid bilayers. 1982 Biochemistry pmid:7138849
Wolf BA et al. Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. 1989 Biochemistry pmid:2504278
Davis PJ et al. Gel to liquid-crystalline transition temperatures of water dispersions of two pairs of positional isomers of unsaturated mixed-acid phosphatidylcholines. 1981 Biochemistry pmid:7260060
HIRSHFIELD IN and KORITZ SB THE STIMULATION OF PREGNENOLONE SYNTHESIS IN THE LARGE PARTICLES FROM RAT ADRENALS BY SOME AGENTS WHICH CAUSE MITOCHONDRIAL SWELLING. 1964 Biochemistry pmid:14269324
Zornetzer GA et al. Solution structures of spinach acyl carrier protein with decanoate and stearate. 2006 Biochemistry pmid:16618110
Horváth LI et al. Exchange rates at the lipid-protein interface of myelin proteolipid protein studied by spin-label electron spin resonance. 1988 Biochemistry pmid:2450570
Gomez GA et al. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. 2004 Biochemistry pmid:15096040
Iot T et al. Synthesis of a new phosphatidylserine spin-label and calcium-induced lateral phase separation in phosphatidylserine-phosphatidylcholine membranes. 1975 Biochemistry pmid:167814
Ramanadham S et al. Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. 1993 Biochemistry pmid:8257685
Malykh EV et al. Effect of hydrophobization of basic pancreatic proteinase inhibitor on the inhibition of bovine trypsin and human leukocyte elastase. 1998 Biochemistry Mosc. pmid:9864442
Prasinou P et al. Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. 2017 Biochim Biophys Acta Biomembr pmid:28688796
Wheelan P and Clay KL Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. 1992 Biochim. Biophys. Acta pmid:1511005
CREASEY WA Observations on the activation of stearic acid by rat-liver preparations. 1962 Biochim. Biophys. Acta pmid:14023748
Fitch CD et al. A role for linoleic acid in erythrocytes infected with Plasmodium berghei. 2000 Biochim. Biophys. Acta pmid:11113630
Aspbury RA et al. Fatty acylation of polypeptides in the nematode Caenorhabditis elegans. 1998 Biochim. Biophys. Acta pmid:9507081
Clandinin MT et al. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. 1997 Biochim. Biophys. Acta pmid:9219909
Thompson W and Belina H Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. 1986 Biochim. Biophys. Acta pmid:3707975
Kordyukova LV et al. Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. 2011 Biochim. Biophys. Acta pmid:21420932
Walsh CE et al. Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. 1983 Biochim. Biophys. Acta pmid:6402027
Galpin JR and Allen JC The influence of micelle formation on lipoxygenase kinetics. 1977 Biochim. Biophys. Acta pmid:409436
Bolton P and Harwood JL Some characteristics of soluble fatty acid synthesis in germinating pea seeds. 1977 Biochim. Biophys. Acta pmid:20971
DAVIDOFF FF THE METABOLISM OF 9(10)-HYDROXYSTEARIC ACID BY THE CELLULAR SLIME MOLD, DICTYOSTELIUM DISCOIDEUM. 1964 Biochim. Biophys. Acta pmid:14220732
Morgan H et al. Proton transport at the monolayer-water interface. 1991 Biochim. Biophys. Acta pmid:1848448
Chien JL and Hogan EL Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. 1980 Biochim. Biophys. Acta pmid:7236652
ANDERSON RL and TOVE SB GLYCERIDE DISTRIBUTION OF FATTY ACIDS ASSIMILATED BY ADIPOSE TISSUE. 1964 Biochim. Biophys. Acta pmid:14250489
PASCAUD M [THE PHOSPHOLIPIDS OF THE HEPATIC CELL. FUNCTIONAL INTERPRETATION OF THEIR RENEWAL. I. NATURE. SPECIFICITY OF THEIR CONSTITUTIVE FATTY ACIDS]. 1964 Biochim. Biophys. Acta pmid:14250490
DOBIASOVA M et al. FATTY ACID COMPOSITION IN DEVELOPING RATS. FATTY ACID COMPOSITION OF TRIGLYCERIDES AND PHOSPHOLIPIDS IN SOME ORGANS OF THE RAT DURING POSTNATAL DEVELOPMENT. 1964 Biochim. Biophys. Acta pmid:14250492
WILLEBRANDS AF UTILIZATION OF INDIVIDUAL NON-ESTERIFIED FATTY ACIDS BY THE ISOLATED PERFUSED RAT HEART. 1964 Biochim. Biophys. Acta pmid:14250498
Avdulov NA et al. Lipid binding to sterol carrier protein-2 is inhibited by ethanol. 1999 Biochim. Biophys. Acta pmid:9931423
Kumar SS et al. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. 2014 Biochim. Biophys. Acta pmid:24440669
Redgrave TG et al. The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. 1994 Biochim. Biophys. Acta pmid:8117751
Miller RW and De La Roche IA Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. 1976 Biochim. Biophys. Acta pmid:182261
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786