stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Foreign Bodies D005547 5 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Arteriosclerosis D001161 86 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Ocloo FCK et al. Effects of stearic acid and gamma irradiation, alone and in combination, on pasting properties of high amylose maize starch. 2016 Food Chem pmid:26212935
Patadia R et al. Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets. 2016 Pharm Dev Technol pmid:25566928
Souza AF et al. Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. 2016 Int J Mol Sci pmid:27669227
Teh SS et al. Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification. 2016 J Oleo Sci pmid:27477075
Sun Y et al. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. 2016 J. Lipid Res. pmid:27371261
Du H et al. Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene. 2016 BMC Plant Biol. pmid:27297560
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
Jeyanathan J et al. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. 2016 BMC Microbiol. pmid:27283157
Hashemi Goradel N et al. Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid. 2016 Iran. Biomed. J. pmid:27090202
Ma Y et al. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. 2016 Molecules pmid:26938513
Šrámek J et al. p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. 2016 Int J Mol Sci pmid:26861294
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Fretts AM et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. 2016 J. Nutr. pmid:26701797
Sergeant S et al. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. 2016 Br. J. Nutr. pmid:26615716
Mazel V et al. Reevaluation of the diametral compression test for tablets using the flattened disc geometry. 2016 Int J Pharm pmid:27702696
Nie H et al. Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. 2016 Mol. Pharm. pmid:27542728
Passerini N et al. Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model. 2016 Int J Pharm pmid:27530293
Karthik S et al. Quillaja saponin: A prospective emulsifier for the preparation of solid lipid nanoparticles. 2016 Colloids Surf B Biointerfaces pmid:27521748
Ghate VM et al. Nanostructured lipid carriers for the topical delivery of tretinoin. 2016 Eur J Pharm Biopharm pmid:27519827
Ohiri RC and Bassey EE Gas Chromatography-Mass Spectrometry Analysis of Constituent Oil from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from Nigeria. 2016 Int J Med Mushrooms pmid:27481303
Monteyne T et al. Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. 2016 Int J Pharm pmid:27452420
Ariyasu A et al. Delay effect of magnesium stearate on tablet dissolution in acidic medium. 2016 Int J Pharm pmid:27444551
Schulze C et al. A one-stage cultivation process for lipid- and carbohydrate-rich biomass of Scenedesmus obtusiusculus based on artificial and natural water sources. 2016 Bioresour. Technol. pmid:27394996
Mužíková J and Kubíčková A A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride. 2016 Acta Pharm pmid:27383891
Yang D et al. Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine. 2016 Anticancer Res. pmid:27354583
Liu H et al. Self-assembled dual-modality contrast agents for non-invasive stem cell tracking via near-infrared fluorescence and magnetic resonance imaging. 2016 J Colloid Interface Sci pmid:27299677
Hu Y et al. Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier. 2016 Oncotarget pmid:27825127
Billès E et al. Cellulose oligomers production and separation for the synthesis of new fully bio-based amphiphilic compounds. 2016 Carbohydr Polym pmid:27577903
Krasnou I et al. Permeability of water and oleic acid in composite films of phase separated polypropylene and cellulose stearate blends. 2016 Carbohydr Polym pmid:27516292
Liu L et al. Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. 2016 Eur J Clin Nutr pmid:26733041
Zhang C et al. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. 2016 Int J Pharm pmid:26943975
Zhang Y et al. CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. 2016 Langmuir pmid:26907546
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Lohan SB et al. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers. 2016 Int J Pharm pmid:26853315
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109
Lavergne SN et al. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. 2016 Vet. Dermatol. pmid:26748887
Baig MS et al. Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity. 2016 Int. J. Biol. Macromol. pmid:26740466
Adler C et al. Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion. 2016 Int J Pharm pmid:26721729
Wood MH et al. Comparative Adsorption of Saturated and Unsaturated Fatty Acids at the Iron Oxide/Oil Interface. 2016 Langmuir pmid:26707597
Bothun GD et al. Cooperative effects of fatty acids and n-butanol on lipid membrane phase behavior. 2016 Colloids Surf B Biointerfaces pmid:26700234
Uvanesh K et al. Effect of Span 60 on the Microstructure, Crystallization Kinetics, and Mechanical Properties of Stearic Acid Oleogels: An In-Depth Analysis. 2016 J. Food Sci. pmid:26677007
Toral PG et al. Does supplemental 18:0 alleviate fish oil-induced milk fat depression in dairy ewes? 2016 J. Dairy Sci. pmid:26627853
Boiret M et al. Setting local rank constraints by orthogonal projections for image resolution analysis: application to the determination of a low dose pharmaceutical compound. 2015 Anal. Chim. Acta pmid:26388474
Veit M and Siche S S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? 2015 Vaccine pmid:26387429
Wang D et al. One-pot synthesized hierarchical zeolite supported metal nanoparticles for highly efficient biomass conversion. 2015 Chem. Commun. (Camb.) pmid:26361087
Xu L et al. The Surface Modification and Antimicrobial Activity of Basic Magnesium Hypochlorite Nanoparticles. 2015 J Nanosci Nanotechnol pmid:26353638
Zhang X et al. Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. 2015 J Nanosci Nanotechnol pmid:26353513
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
Seethamraju S et al. Reactive interlayer based ultra-low moisture permeable membranes for organic photovoltaic encapsulation. 2015 Phys Chem Chem Phys pmid:26278515
Yang W et al. Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging. 2015 ACS Appl Mater Interfaces pmid:26257133
Zhong T et al. Effects of ultrasound treatment on lipid self-association and properties of methylcellulose/stearic acid blending films. 2015 Carbohydr Polym pmid:26256202
He H et al. VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. 2015 Int J Pharm pmid:26253378
Xu W et al. Bilayers at High pH in the Fatty Acid Soap Systems and the Applications for the Formation of Foams and Emulsions. 2015 J Phys Chem B pmid:26237503
Hoffmann M et al. Investigation into process-induced de-aggregation of cohesive micronised API particles. 2015 Int J Pharm pmid:26235919
Gong X et al. Dependence of tablet brittleness on tensile strength and porosity. 2015 Int J Pharm pmid:26226338
Liu G et al. Cell membrane-inspired polymeric micelles as carriers for drug delivery. 2015 Biomater Sci pmid:26222292
Qu L et al. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. 2015 Eur J Pharm Sci pmid:26215464
Bera H et al. Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone. 2015 Int. J. Biol. Macromol. pmid:25861741
Badal Tejedor M et al. Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure. 2015 Int J Pharm pmid:25841569
Rozman Peterka T et al. Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. 2015 J Pharm Biomed Anal pmid:25804434
Kelidari HR et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. 2015 Colloids Surf B Biointerfaces pmid:25797482
Seyedi S et al. Improving the physical and moisture barrier properties of Lepidium perfoliatum seed gum biodegradable film with stearic and palmitic acids. 2015 Int. J. Biol. Macromol. pmid:25795389
Su Y et al. Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy. 2015 Mol. Pharm. pmid:25751168
Phaechamud T et al. Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. 2015 Mater Sci Eng C Mater Biol Appl pmid:25746264
Jedinger N et al. Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids. 2015 Eur J Pharm Biopharm pmid:25733499
Castellanos-Tapia L et al. Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. 2015 Nutr Res pmid:25727313
Kerth CR et al. Consumer sensory evaluation, fatty acid composition, and shelf-life of ground beef with subcutaneous fat trimmings from different carcass locations. 2015 Meat Sci. pmid:25688688
Tai Z et al. Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo. 2015 Biomacromolecules pmid:25686200
Thakkar A et al. Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. 2015 Int. J. Oncol. pmid:25652350
Sagiri SS et al. Stearic acid based oleogels: a study on the molecular, thermal and mechanical properties. 2015 Mater Sci Eng C Mater Biol Appl pmid:25579972
Rana S et al. A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. 2015 J Control Release pmid:25575863
Wei X et al. Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. 2015 Carbohydr Polym pmid:25542116
Zeng Q et al. Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. 2015 J Control Release pmid:25540903
Piantoni P et al. Milk production responses to dietary stearic acid vary by production level in dairy cattle. 2015 J. Dairy Sci. pmid:25529423
Vercruysse J et al. Use of a continuous twin screw granulation and drying system during formulation development and process optimization. 2015 Eur J Pharm Biopharm pmid:25528462
Schrank S et al. The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. 2015 Int J Pharm pmid:25526671
Foraita S et al. Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. 2015 Chemistry pmid:25504844
Askari M et al. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. 2015 Clin Transl Oncol pmid:25351172
Cantor SL et al. Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. 2015 Drug Dev Ind Pharm pmid:25000481
Qu L et al. Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015 Drug Dev Ind Pharm pmid:24738790
Vervaeck A et al. Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. 2015 Eur J Pharm Biopharm pmid:26428938
Van Hoeck V et al. Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations. 2015 Reprod. Fertil. Dev. pmid:24360349
Nandini PT et al. Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles. 2015 Drug Deliv pmid:24283392
Chen Q et al. Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. 2015 Artif Cells Nanomed Biotechnol pmid:24093764
Miao H et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. 2015 Sci Rep pmid:26271607
Soliman HM et al. Utilization of Stearic acid Extracted from Olive Pomace for Production of Triazoles, Thiadiazoles and Thiadiazines Derivatives of Potential Biological Activities. 2015 J Oleo Sci pmid:26250422
Fala AM et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. 2015 Sci Rep pmid:26237540
Senyilmaz D et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. 2015 Nature pmid:26214738
Gotoh K et al. Introduction of Atmospheric Pressure Plasma to Aqueous Detergent Processes. 2015 J Oleo Sci pmid:26179001
Astanina K et al. Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells. 2015 Sci Rep pmid:26095213
Vraníková B et al. Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods. 2015 Biomed Res Int pmid:26075249
Patil PS et al. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. 2015 Nat Commun pmid:26037164
Onishi H et al. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. 2015 Biol. Pharm. Bull. pmid:26027834
Rehman M et al. Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. 2015 Int J Nanomedicine pmid:25897224
Harding SV et al. Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. 2015 BMC Res Notes pmid:25879456
Silva-Neta IC et al. Expression of genes related to tolerance to low temperature for maize seed germination. 2015 Genet. Mol. Res. pmid:25867416
Jung SW et al. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. 2015 PLoS ONE pmid:25793403
Othman AR et al. Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. 2015 BMC Complement Altern Med pmid:25652309
Aardema H et al. Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. 2015 J. Dairy Sci. pmid:25648816
Ma W et al. Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. 2015 Am. J. Clin. Nutr. pmid:25527759