stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Foreign Bodies D005547 5 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Arteriosclerosis D001161 86 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Fatemi SH et al. The glycophospholipid anchor of Thy-1. Biosynthetic labeling experiments with wild-type and class E Thy-1 negative lymphomas. 1987 J. Biol. Chem. pmid:2881925
Nakanishi H et al. Comparative studies on additive effects of sodium dodecylbenzensulfonate and sodium stearate on uptake of chemicals by willow shiner (Gnathopogon caerulescens). 1987 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2882933
Bergquist SO et al. Erythromycin in the treatment of pertussis: a study of bacteriologic and clinical effects. 1987 Pediatr. Infect. Dis. J. pmid:2885802
Zara GP et al. Erythromycin and gastrointestinal motility. 1987 Lancet pmid:2889954
Hohl C and Rösen P Arachidonic acid metabolism in isolated rat heart myocytes. 1987 Prog. Clin. Biol. Res. pmid:3118380
Taylor AJ et al. An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. 1987 Clin. Chem. pmid:3119255
Shanson DC Antibiotic prophylaxis of infective endocarditis in the United Kingdom and Europe. 1987 J. Antimicrob. Chemother. pmid:3119557
Dudley DT et al. Depletion of arachidonic acid from GH3 cells. Effects on inositol phospholipid turnover and cellular activation. 1987 Biochem. J. pmid:3120699
Faden AI et al. Alterations in lipid metabolism, Na+,K+-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury. 1987 J. Neurochem. pmid:3033150
Imai A and Gershengorn MC Measurement of lipid turnover in response to thyrotropin-releasing hormone. 1987 Meth. Enzymol. pmid:3037241
Habib NA et al. Stearic acid and carcinogenesis. 1987 Br. J. Cancer pmid:3689663
Rhoads DE et al. Metabolism of saturated fatty acids by Paramecium tetraurelia. 1987 J. Lipid Res. pmid:3430068
Kaya K and Nohara K Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena. 1987 Chem. Biol. Interact. pmid:3690725
Habib NA et al. Desaturation-producing factor present in the tissue, blood, and urine of cancer patients. 1987 Cancer Detect. Prev. pmid:3568009
Wang ST et al. A comparison of fatty acid composition of cholesteryl esters in subjects at various concentrations of serum lipid. 1987 Clin. Biochem. pmid:3568345
Pospísilová B and Kubes J [Stability of erythromycin stearate in coated tablets during the action of gastric juice in vitro]. 1987 Cesk Farm pmid:3581192
Worman CP et al. Saturation index of blood cell membrane fatty acids before and after IFN treatment in hairy cell leukemia. 1987 Leukemia pmid:3669764
Caglayan S et al. Is medical therapy effective for regional lymphadenitis following BCG vaccination? 1987 Am. J. Dis. Child. pmid:3673975
Venho VM et al. The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. 1987 Methods Find Exp Clin Pharmacol pmid:3683018
Bridges CD et al. Rhodopsin, vitamin A, and interstitial retinol-binding protein in the rd chicken. 1987 Invest. Ophthalmol. Vis. Sci. pmid:3557867
Hope MJ and Cullis PR Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. 1987 J. Biol. Chem. pmid:3558410
Adebayo GI et al. Time-dependent inhibition of theophylline elimination by erythromycin stearate. 1986 Sep-Oct Biopharm Drug Dispos pmid:3779037
Goto S et al. Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen. 1986 Oct-Dec J Microencapsul pmid:3508190
Goto S et al. Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen. 1986 Oct-Dec J Microencapsul pmid:3508191
Alcalay J et al. Asymptomatic liver injury due to erythromycin stearate. 1986 Jul-Aug Drug Intell Clin Pharm pmid:3743417
Giudici TA et al. Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. 1986 Biochem. Med. Metab. Biol. pmid:2872907
Marchut E et al. The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. 1986 Acta Biochim. Pol. pmid:2940781
Mock T et al. Effects of fatty acids on phosphatidylcholine biosynthesis in isolated hamster heart. 1986 Biochem. Cell Biol. pmid:3013250
Yoshida S et al. Cerebral phosphoinositide, triacylglycerol, and energy metabolism in reversible ischemia: origin and fate of free fatty acids. 1986 J. Neurochem. pmid:3016186
Reddy TS et al. Fatty acid composition and arachidonic acid metabolism in vitreous lipids from canine and human eyes. 1986 Curr. Eye Res. pmid:3089690
Dudley DT and Spector AA Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. 1986 Biochem. J. pmid:3098231
Chester DW et al. The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. 1986 Biochim. Biophys. Acta pmid:3741857
Tsao FH Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung. 1986 Lipids pmid:3796238
Ito Y et al. Fatty acid synthetase as a thermoreceptor in Candida utilis. 1986 J. Biochem. pmid:3745143
Muralidharan FN and Muralidharan VB Phytanoyl-CoA ligase activity in rat liver. 1986 Biochem. Int. pmid:3753503
Ball MD et al. Acyl coenzyme A:retinol acyltransferase activity and the vitamin A content of polar bear (Ursus maritimus) liver. 1986 Comp. Biochem. Physiol., B pmid:3757481
van den Reek MM et al. Use of published analyses of food items to determine dietary trans octadecenoic acid. 1986 J Am Diet Assoc pmid:3760430
Sugimoto Y et al. A 2H NMR study on alteration of the membrane organization of mouse B16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate. 1986 J. Biochem. pmid:3818567
Thompson W and Belina H Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. 1986 Biochim. Biophys. Acta pmid:3707975
Heape AM et al. Technique for injection into the sciatic nerve of the mouse for quantitative in vivo metabolic studies. 1986 Anal. Biochem. pmid:3717558
Caponnetto A et al. [Correlations between unsaturated fatty acids and medium C-chain triglycerides]. 1986 Boll. Soc. Ital. Biol. Sper. pmid:3718739
Beaumelle BD and Vial HJ Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. 1986 Biochim. Biophys. Acta pmid:3719005
Pajor L et al. Microsomal desaturation of stearic acid in relation to lymphocyte activation. 1986 Arch. Biochem. Biophys. pmid:3485399
Ras GJ and Anderson R An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. 1986 J. Antimicrob. Chemother. pmid:3486178
Chalupa W et al. Ruminal fermentation in vivo as influenced by long-chain fatty acids. 1986 J. Dairy Sci. pmid:3722545
Yamamoto O Radiation-induced crosslinks between carboxylic acids and compounds of biological interest. 1986 Radiat. Res. pmid:3952268
Villa P et al. Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver. 1986 J. Antibiot. pmid:3084433
Okabe H et al. Effects of anti-convulsants on fatty acid metabolism in human serum. 1986 Tohoku J. Exp. Med. pmid:3705068
Siegel I et al. Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. 1986 Fertil. Steril. pmid:2868925
Johansson ME and Nicklasson M Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. 1986 J. Pharm. Pharmacol. pmid:2869127