stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

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What functions are associated with stearic acid?


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What lipids are associated with stearic acid?

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What genes are associated with stearic acid?

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What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
SULMAN FG A note on the resorption and excretion of riboflavine from aluminium monostearate suspensions in the rat. 1955 J. Pharm. Pharmacol. pmid:14392601
GEYER RP et al. Aerobic C14O2 formation from carboxyl-labeled stearic and palmitic acids in the presence of ascorbic acid. 1955 Arch. Biochem. Biophys. pmid:14377605
GLASCOCK RF and REINIUS LR Studies on the origin of milk fat. 1. The location of tritium in stearic acid produced by the catalytic addition of tritium to elaidic acid. 1956 Biochem. J. pmid:13315207
TOVE SB et al. Turnover of palmitic, stearic, and unsaturated fatty acids in rat liver. 1956 J. Biol. Chem. pmid:13278335
MEAD JF et al. Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. 1956 J. Biol. Chem. pmid:13278347
BLOMSTRAND R et al. On the intestinal absorption of 2, 2-dimethylstearic acid fed as free acid or as glyceride. 1956 Acta Physiol. Scand. pmid:13339456
KERN W et al. [Suggestions for the composition of the general section on ointments and salve bases and emulsifiers in the German Pharmacopeia (DAB 6, Annex). II]. 1956 Hautarzt pmid:13345190
Buensod M and Favarger P [Observations on the digestibility of palmitic and stearic acids and their glyceric esters in rats]. 1956 Helv Physiol Pharmacol Acta pmid:13405350
COOKE NJ et al. The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). 1956 Biochem. J. pmid:13363830
JAMES AT and MARTIN AJ Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. 1956 Biochem. J. pmid:13315260
HUME JC and FACIO G An analysis of the results of the treatment of yaws with a single injection of procaine penicillin with 2% aluminium monostearate. 1956 Bull. World Health Organ. pmid:13404472
FABER JS A note on the assay of zinc stearate. 1957 J Am Pharm Assoc Am Pharm Assoc pmid:13491438
BRZEZINSKI A et al. Prolonged effect of riboflavin: aluminum monostearate suspensions in man. 1957 J Am Pharm Assoc Am Pharm Assoc pmid:13438726
KARVINEN E et al. Effect of palmitic and stearic acid on cholesterol absorption in man. 1957 J Appl Physiol pmid:13462909
LONG CL et al. Studies on absorption and metabolism of propylene glycol distearate. 1958 Arch. Biochem. Biophys. pmid:13584006
LONG CL et al. An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate. 1958 Arch. Biochem. Biophys. pmid:13584007
CONIGLIO JG and CATE DL The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. 1958 J. Biol. Chem. pmid:13549425
DAWSON RM The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. 1958 Biochem. J. pmid:13522653
HARDING HE Some enquiries into the toxicology of zinc stearate. 1958 Br J Ind Med pmid:13523087
RUTSTEIN DD et al. Effects of linolenic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue-culture. 1958 Lancet pmid:13515277
COX AJ and DEEDS F Dietary production of lipogranuloma in rats. 1958 Mar-Apr Am. J. Pathol. pmid:13520907
KELLERSHOHN C and BENICHOUX R [Comparative study of the drainage through the lymphatic vessels of a radioactive fat, ethyl diiodosterate labeled with I 131, and a radioactive colloidal substance, colloidal gold 198]. 1958 May-Jun Minerva Nucl pmid:13565747
GERSHFELD NL and SHANES AM Antagonism of veratrine by calcium ion in monolayers of stearic acid. 1959 Science pmid:13658972
BLOMSTRAND R et al. Asymmetric incorporation of linoleic acid-1-C14 and stearic acid-1-C14 into human lymph lecithins during fat absorption. 1959 Proc. Soc. Exp. Biol. Med. pmid:13645714
FITZHUGH OG et al. Chronic oral toxicities of four stearic acid emulsifiers. 1959 Toxicol. Appl. Pharmacol. pmid:13659539
SKIPSKI VP et al. Identification of 2-hydroxystearic acid in spinal cord phrenosine by chromatographic separation of hydroxy fatty acids. 1959 Arch. Biochem. Biophys. pmid:13661981
HURLEY HJ and SHELLEY WB The colloidal state as a stimulus for non-allergic epithelioid granulomas: experimental studies in man with pure sodium stearate and palmitate. 1959 J. Invest. Dermatol. pmid:14405513
LIN TM et al. Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. 1960 Am. J. Physiol. pmid:14417022
SHANES AM and GERSHFELD NL Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action. 1960 J. Gen. Physiol. pmid:13750673
FOTI L et al. [In vitro liver biosynthesis of cholesterol from acetate, stearate and linoleate 1-C-14]. 1961 Boll. Soc. Ital. Biol. Sper. pmid:13958917
AGARWAL SC et al. Blood-level duration limit test of procaine benzylpenicillin in sheep. 1961 Bull. World Health Organ. pmid:13859560
DAVIDOFF F and KORN ED Synthesis of unsaturated fatty acids in the cellular slime mold. 1962 Biochem. Biophys. Res. Commun. pmid:14025332
DEYKIN D and GOODMAN DS The hydrolysis of long-chain fatty acid esters of cholesterol with rat liver enzymes. 1962 J. Biol. Chem. pmid:14027461
TROUT DL and ESTES EH Factors affecting liver uptake of serum free stearic acid-1-C14. 1962 Am. J. Physiol. pmid:13994303
WALLEN LL et al. The microbiological production of 10-hydroxystearic acid from oleic acid. 1962 Arch. Biochem. Biophys. pmid:13998583
CREASEY WA Observations on the activation of stearic acid by rat-liver preparations. 1962 Biochim. Biophys. Acta pmid:14023748
JAMES AT [Studies on the biosynthesis of 18 carbon mono-and tri-unsaturated fatty acids by gas phase chromatography]. 1962 Bull. Soc. Chim. Biol. pmid:13957228
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GUTIERREZ J et al. Lipid metabolism of rumen ciliates and bacteria. I. Uptake of fatty acids by Isotricha prostoma and Entodinium simplex. 1962 Appl Microbiol pmid:13951437
YOUNG RJ and GARRETT RL EFFECT OF OLEIC AND LINOLEIC ACIDS ON THE ABSORPTION OF SATURATED FATTY ACIDS IN THE CHICK. 1963 J. Nutr. pmid:14100991
GOUERE P [BIOCHEMICAL ASPECT AND DIETETIC ROLE OF GRAPE SEED OIL]. 1963 Aliment Vie pmid:14135213
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SHIFRINE M and MARR AG THE REQUIREMENT OF FATTY ACIDS BY PITYROSPORUM OVALE. 1963 J. Gen. Microbiol. pmid:14053273
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HALL PF et al. Synthesis of fatty acids by testicular tissue in vitro. 1963 Can J Biochem Physiol pmid:13952129
RAZIN S and ROTTEM S FATTY ACID REQUIREMENTS OF MYCOPLASMA LAIDLAWII. 1963 J. Gen. Microbiol. pmid:14114935
HJORTH N and TROLLE-LASSEN C SKIN REACTIONS TO OINTMENT BASES. 1963 Trans St Johns Hosp Dermatol Soc pmid:14116129