stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

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What functions are associated with stearic acid?


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What lipids are associated with stearic acid?

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What genes are associated with stearic acid?

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What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Rosenthal MD and Whitehurst MC Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. 1983 Biochim. Biophys. Acta pmid:6615875
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Philip J and Daly RE Test for selection of erythromycin stearate bulk drug for tablet preparation. 1983 J Pharm Sci pmid:6620167
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Eccleston GM The influence of fatty alcohols on the structure and stability of creams prepared with polyethylene glycol 1000 monostearate/fatty alcohols. 1982 Int J Cosmet Sci pmid:19469959
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Akesson B Content of phospholipids in human diets studied by the duplicate-portion technique. 1982 Br. J. Nutr. pmid:7066286
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Pritzker KP et al. Adrenal and hepatic calcium stearate crystal deposits in dogs fed a thiamine-deficient diet. 1982 Am. J. Vet. Res. pmid:7103233
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Mroso PV et al. Solid-state stability of aspirin in the presence of excipients: kinetic interpretation, modeling, and prediction. 1982 J Pharm Sci pmid:7143203
Katz AM and Messineo FC Fatty acid effects on membranes: possible role in the pathogenesis of ischemic myocardial damage. 1982 J. Mol. Cell. Cardiol. pmid:7143451
Lerk CF et al. Interaction of tablet disintegrants and magnesium stearate during mixing. II. Effect on dissolution rate. 1982 Pharm Acta Helv pmid:7146030
Warner T and Zar JH Fatty acid composition of brown fat and brain fat of the little brown bat, Myotis lucifugus, during hibernation. 1982 Comp. Biochem. Physiol., B pmid:7151405
Iliopoulou A et al. Should erythromycin dose be altered in haemodialysis patients? 1982 Eur. J. Clin. Pharmacol. pmid:7151848
Faas FH and Carter WJ Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism. 1982 Biochem. J. pmid:7181859
Bazan NG et al. High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. 1982 Biochim. Biophys. Acta pmid:6215065
Nozawa CM and Apostolov K Increase in the saturation of C18 fatty acids induced by coxsackie B6 virus in Vero cells. 1982 Virology pmid:6285601