stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Yaws D015001 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Chancroid D002602 4 associated lipids
Relapsing Fever D012061 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
PILZ W and HOERLEIN H [INVESTIGATIONS CONCERNING ENZYMES OF HUMAN BLOOD, VIII. THE POSSIBLE ROLE OF ARYLESTERASE I IN HUMAN FAT METABOLISM]. 1964 Hoppe-Seyler's Z. Physiol. Chem. pmid:14124985
WAIBEL PE and MRAZ FR CALCIUM, STRONTIUM AND PHOSPHORUS UTILIZATION BY CHICKS AS INFLUENCED BY NUTRITIONAL AND ENDOCRINE VARIATIONS. 1964 J. Nutr. pmid:14210023
VAHOUNY GV et al. MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. 1964 Arch. Biochem. Biophys. pmid:14211570
SHELTON DC et al. THE UPTAKE AND DISTRIBUTION OF STEARIC ACID BY SUBCELLULAR COMPONENTS OF INTESTINAL MUCOSA. 1964 Am. J. Clin. Nutr. pmid:14240483
JACKSON HD et al. FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. 1964 Arch. Biochem. Biophys. pmid:14240563
GOTO Y et al. EXPERIMENTAL STUDY ON THE LIPID METABOLISM IN THE HEART MUSCLE. 1964 Jpn. Circ. J. pmid:14167720
KRITCHEVSKY D EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS FED CHOLESTEROL-FREE DIETS. 1964 Jan-Feb J Atheroscler Res pmid:14112225
MAKLEIT JK et al. THIN LAYER AND GAS CHROMATOGRAPHIC ANALYSIS OF SYPHILIS ANTIGENS. 1964-1965 Acta Microbiol Acad Sci Hung pmid:14314670
SCHROEPFER GJ and BLOCH K THE STEREOSPECIFIC CONVERSION OF STEARIC ACID TO OLEIC ACID. 1965 J. Biol. Chem. pmid:14253467
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
KANFER J OBSERVATIONS ON CEREBROSIDE METABOLISM IN VIVO. 1965 J. Biol. Chem. pmid:14275111
KEITEL HG and CHU E PREMATURE INFANT FEEDING. I. THE CLINICAL USEFULNESS OF CALORIC CONCENTRATION OF FORMULAS, OF EARLY VERSUS LATE FEEDINGS AND OF LOW STEARIC ACID CONTENT FORMULAS. 1965 Pediatr. Clin. North Am. pmid:14276882
KORN ED et al. SYNTHESIS OF UNSATURATED FATTY ACIDS IN THE SLIME MOLD PHYSARUM POLYCEPHALUM AND THE ZOOFLAGELLATES LEISHMANIA TARENTOLAE, TRYPANOSOMA LEWISI, AND CRITHIDIA SP.: A COMPARATIVE STUDY. 1965 J. Lipid Res. pmid:14280472
BACHUR NR et al. FATTY ACID AMIDES OF ETHANOLAMINE IN MAMMALIAN TISSUES. 1965 J. Biol. Chem. pmid:14284696
HANSEN HJ et al. THE EFFECT OF WHOLE-BODY X-IRRADIATION ON THE SYNTHESIS OF INDIVIDUAL FATTY ACIDS IN LIVER SLICES FROM NORMAL AND FASTED RATS. 1965 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. pmid:14309652
LAMBREMONT EN BIOSYNTHESIS OF FATTY ACIDS IN ASEPTICALLY REARED INSECTS. 1965 Comp. Biochem. Physiol. pmid:14314981
ANSTALL HB and TRUJILLO JM DETERMINATION OF FREE FATTY ACIDS IN PLASMA BY A COLORIMETRIC PROCEDURE: AN APPRAISAL OF THE METHOD AND COMPARISON WITH OTHER TECHNICS. 1965 Clin. Chem. pmid:14319230
SHAFRIR E et al. PARTITION OF FATTY ACIDS OF 20-24 CARBON ATOMS BETWEEN SERUM ALBUMIN AND LIPOPROTEINS. 1965 Biochim. Biophys. Acta pmid:14320230
GOERANSSON G THE METABOLISM OF FATTY ACIDS IN THE RAT. IV. STEARIC ACID. 1965 Acta Physiol. Scand. pmid:14321752
Keys A et al. Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet. 1965 Metab. Clin. Exp. pmid:25286466