stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Yaws D015001 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Chancroid D002602 4 associated lipids
Relapsing Fever D012061 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Nadkarni MS et al. Treatment of acute bacterial infections of the upper respiratory tract. 1977 Curr Med Res Opin pmid:326492
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Cooksley WG and Powell LW Erythromycin jaundice: diagnosis by an in vitro challenge test. 1977 Aust N Z J Med pmid:269690
Burns CP et al. Fatty acid utilization by L1210 murine leukemia cells. 1977 Cancer Res. pmid:558821
Bolton P and Harwood JL Fatty acid biosynthesis by a particulate preparation from germinating pea. 1977 Biochem. J. pmid:579600
Oriel JD et al. Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis. 1977 Scott Med J pmid:601555
Giacobino JP and Chmelar M The role of chain elongation systems in the supplying of fatty acids to the adipocyte membrane lipids. 1977 Biochim. Biophys. Acta pmid:861235
Mansbach CM The origin of chylomicron phosphatidylcholine in the rat. 1977 J. Clin. Invest. pmid:874099
Bolton P and Harwood JL Some characteristics of soluble fatty acid synthesis in germinating pea seeds. 1977 Biochim. Biophys. Acta pmid:20971
Rowe RC The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. 1977 J. Pharm. Pharmacol. pmid:22617
Sixsmith D The properties of tablets containing microcrystalline cellulose. 1977 J. Pharm. Pharmacol. pmid:15069
Newton JM and Razzo FN The in vitro bioavailability of various drugs formulated as hard gelatin capsules. 1977 J. Pharm. Pharmacol. pmid:17668
Newton JM and Razzo FN The influence of additives on the presentation of a drug in hard gelatin capsules. 1977 J. Pharm. Pharmacol. pmid:17694
Uyesaka N Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. J. Membrane Biol. 27:283. 1977 J. Membr. Biol. pmid:190405
Moës A [Influence of the addition of aluminium stearate and of colloidal silica on the properties of rectal suppositories formulations (author's transl)]. 1976 Jul-Aug J Pharm Belg pmid:185351
Waring AJ et al. In vivo modification of plant membrane phospholipid composition. 1976 Biochim. Biophys. Acta pmid:953014
Björkhem I On the mechanism of regulation of omega oxidation of fatty acids. 1976 J. Biol. Chem. pmid:956185
Steffen DG and Platner WS Subcellular membrane fatty acids of rat heart after cold acclimation or thyroxine. 1976 Am. J. Physiol. pmid:961919
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Porra RJ and Stumpf PK Lipid biosynthesis in developing and germinating soybean cotyledons. The formation of palmitate and stearate by chopped tissue and supernatant preparations. 1976 Arch. Biochem. Biophys. pmid:987755
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Thies C Development of injectable microcapsules for use in the treatment of narcotic addiction. 1976 Natl Inst Drug Abuse Res Monogr Ser pmid:967230
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Eliasz AW et al. Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds. 1976 Biochim. Biophys. Acta pmid:971432
Graham KC et al. Simple thin-layer chromatographic identification method for erythromycin stearate. 1976 J. Chromatogr. pmid:977688
Matsuda Y et al. Comparative evaluation of tablet lubricants: effect of application method on tablet hardness and ejectability after compression. 1976 J Pharm Sci pmid:978434
Caster WO et al. Effect of dietary palmitate, stearate, oleate and linoleate on the tissue lipid and systolic blood pressure of the rat. 1976 Int J Vitam Nutr Res pmid:1010686
Brown ST Treatment of secondary syphilis. 1976 J Am Vener Dis Assoc pmid:1010778
Hannuksela M et al. Contact sensitivity to emulsifiers. 1976 Contact Derm. pmid:1021350
Horhota ST et al. Effect of storage at specified temperature and humidity on properties of three directly compressible tablet formulations. 1976 J Pharm Sci pmid:1032656
Shen WW et al. Effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide. 1976 J Pharm Sci pmid:1032661
Norwitz G and Galan M Determination of barium and strontium peroxides (active oxygen) in igniters in small-arms tracer ammunition. 1976 Talanta pmid:18961958
Whorton AR et al. The metabolism of (1-14C) stearic acid in rat testicular tissue. 1976 Biochim. Biophys. Acta pmid:1252481
Fee JV et al. Influence of hydrophobic materials on dissolution of a nondisintegrating hydrophilic solid (potassium chloride). 1976 J Pharm Sci pmid:1255446
Yamashita T et al. [Blood concentration and urinary excretion in human of OE-7, a gastric hard capsule containing enteric-coated granules. I (author's transl)]. 1976 Jpn J Antibiot pmid:1263346
Warhurst DC et al. The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei. 1976 Ann Trop Med Parasitol pmid:788656
Boggiano BG and Gleeson M Gastric acid inactivation of erythromycin stearate in solid dosage forms. 1976 J Pharm Sci pmid:5588
Ahmed M and Enever RP Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations [proceedings]. 1976 J. Pharm. Pharmacol. pmid:12326
Sabbah A [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. 1976 Nouv Presse Med pmid:1264643
Lundberg B Thermal properties of systems containing cholesteryl esters and triglycerides. 1976 Acta Chem. Scand., B, Org. Chem. Biochem. pmid:1266525
Pickart LR and Thaler MM Free fatty acids and albumin as mediators of thrombin-stimulated fibrinogen synthesis. 1976 Am. J. Physiol. pmid:1267031
Musty PR and Nickless G Extractants for organochlorine insecticides and polychlorinated biphenyls from water. 1976 J. Chromatogr. pmid:818099
Soler-Argilaga C et al. The effect of sex on the quantity and properties of the very low density lipoprotein secreted by the liver in vitro. 1976 J. Lipid Res. pmid:178815
Uyesaka N et al. Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. 1976 J. Membr. Biol. pmid:181579
Miller RW and De La Roche IA Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. 1976 Biochim. Biophys. Acta pmid:182261
Ruf HH and Gratzl M Binding of nitroxide stearate spin labels to bovine serum albumin. 1976 Biochim. Biophys. Acta pmid:184832
Todorow S and Elies W [Oily contrast medium in liquor space following myelography. A clinical-radiological study on extent, velocity and ways of elimination of monoiodine stearate]. 1976 Neurochirurgia (Stuttg) pmid:185538
Marai L et al. Identification of isomeric doxyl stearic acids by gas-liquid chromatography and mass spectrometry. 1976 Chem. Phys. Lipids pmid:186203
Zenser TV et al. Spin-labeled stearates as probes for microenvironment of murine thymocyte adenylate cyclase-cyclic adenosine 3':5'-monophosphate system. 1976 J. Biol. Chem. pmid:187588