| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Erectile Dysfunction | D007172 | 19 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Seizures | D012640 | 87 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abe H and Otsuka M | Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. | 2012 | Drug Dev Ind Pharm | pmid:21954869 |
| Li X et al. | Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. | 2016 | Drug Dev Ind Pharm | pmid:26289006 |
| Maghsoodi M et al. | Improved compaction and packing properties of naproxen agglomerated crystals obtained by spherical crystallization technique. | 2007 | Drug Dev Ind Pharm | pmid:18058318 |
| Wei CC and Ge ZQ | Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs). | 2012 | Drug Dev Ind Pharm | pmid:22181005 |
| Rodriguez L et al. | Hot air coating technique as a novel method to produce microparticles. | 2004 | Drug Dev Ind Pharm | pmid:15554215 |
| Palmieri GF et al. | Evaluation of the mixing effectiveness of a new powder mixer. | 1998 | Drug Dev Ind Pharm | pmid:15605601 |
| Swaminathan V and Kildsig DO | The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures. | 2000 | Drug Dev Ind Pharm | pmid:10769777 |
| Choi du H et al. | A new experimental design method to optimize formulations focusing on a lubricant for hydrophilic matrix tablets. | 2012 | Drug Dev Ind Pharm | pmid:22348254 |
| Stanisz B et al. | Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations. | 2013 | Drug Dev Ind Pharm | pmid:22348774 |
| Shibata Y et al. | Fluidity and tableting characteristics of a powder solid dispersion of the low melting drugs ketoprofen and ibuprofen with crospovidone. | 2006 | Drug Dev Ind Pharm | pmid:16638683 |
| Sudah OS et al. | Mixing of cohesive pharmaceutical formulations in tote (bin) blenders. | 2002 | Drug Dev Ind Pharm | pmid:12378960 |
| Siaan M et al. | Influence of Avicel PH-301 on the compressibility of alpha-methyldopa and phenobarbitone in direct compression. | 2000 | Drug Dev Ind Pharm | pmid:10914328 |
| Desai SS et al. | Methods for reduction of cohesive forces between carrier and drug in DPI formulation. | 2013 | Drug Dev Ind Pharm | pmid:23050727 |
| Vaithiyalingam SR et al. | Formulation and stability evaluation of ketoprofen sustained-release tablets prepared by fluid bed granulation with Carbopol 971P solution. | 2002 | Drug Dev Ind Pharm | pmid:12476869 |
| Tamilvanan S et al. | In vitro and in vivo evaluation of hydrophilic and hydrophobic polymers-based nicorandil-loaded peroral tablet compared with its once-daily commercial sustained-release tablet. | 2011 | Drug Dev Ind Pharm | pmid:20923389 |
| UÄŸurlu T et al. | Effects of lubricants on binary direct compression mixtures. | 2010 | Drug Discov Ther | pmid:22491169 |
| Nahata MC | Selection of an erythromycin for the treatment of pertussis. | 1988 | Drug Intell Clin Pharm | pmid:3069427 |
| Alcalay J et al. | Asymptomatic liver injury due to erythromycin stearate. | 1986 Jul-Aug | Drug Intell Clin Pharm | pmid:3743417 |
| Carter BL et al. | Gastrointestinal side effects with erythromycin preparations. | 1987 | Drug Intell Clin Pharm | pmid:3498618 |
| Maghsoodi M | Floating-pulsatile release multiparticulate system for chronopharmacotherapy: effect of some hydrophobic additives on the buoyancy and release behavior of particles. | 2014 | Drug Res (Stuttg) | pmid:23950100 |
| Thirupathi G et al. | Role of Isradipine Loaded Solid Lipid Nanoparticles on the Pharmacodynamic Effect in Rats. | 2017 | Drug Res (Stuttg) | pmid:27992936 |
| Schmidt LE and Dalhoff K | Food-drug interactions. | 2002 | Drugs | pmid:12093316 |
| Nakayoshi T et al. | Comparative study on effects of 14- and 16-membered macrolides on gastrointestinal motility in unanaesthetized dogs. | 1988 | Drugs Exp Clin Res | pmid:3265375 |
| de Jong S et al. | A semipermanent coating for preventing protein adsorption at physiological pH in kinetic capillary electrophoresis. | 2012 | Electrophoresis | pmid:22899267 |
| Imamura K et al. | Colony-stimulating factor 1 activates protein kinase C in human monocytes. | 1990 | EMBO J. | pmid:2196173 |
| Stehlin C et al. | X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. | 2001 | EMBO J. | pmid:11689423 |
| Barkai G et al. | Community prescribing and resistant Streptococcus pneumoniae. | 2005 | Emerging Infect. Dis. | pmid:15963276 |
| Maynar M et al. | Menopause-induced changes in lipid fractions and total fatty acids in plasma. | 2001 | Endocr. Res. | pmid:11678583 |
| Wang Y et al. | Chronic effects of different non-esterified fatty acids on pancreatic islets of rats. | 2006 | Endocrine | pmid:16622307 |
| Judd AM and MacLeod RM | Thyrotropin-releasing hormone and lysine-bradykinin stimulate arachidonate liberation from rat anterior pituitary cells through different mechanisms. | 1992 | Endocrinology | pmid:1505463 |
| Canonico PL et al. | Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs. | 1985 | Endocrinology | pmid:2981065 |
| Cheng B et al. | Characterization and identification of an adrenal age-related nonpolar fluorescent substance. | 1996 | Endocrinology | pmid:8641198 |
| El-Assaad W et al. | Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. | 2003 | Endocrinology | pmid:12933690 |
| ELLEFSON RD and MASON HL | EFFECTS OF DEFICIENCY AND EXCESS OF THYROID HORMONE ON THE DISTRIBUTION OF FATTY ACIDS IN LIPIDS OF THE RAT. | 1964 | Endocrinology | pmid:14206987 |
| Pagliassotti MJ et al. | Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. | 2007 | Endocrinology | pmid:17431009 |
| Mu YM et al. | Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. | 2001 | Endocrinology | pmid:11459807 |
| Simonsen ME et al. | Comparison of methods for evaluation of activity of photocatalytic films. | 2012 | Environ Sci Pollut Res Int | pmid:23054739 |
| Lalman JA et al. | Kinetics of glucose fermentation by a mixed culture in the presence of linoleic, oleic, and stearic acid. | 2003 | Environ Technol | pmid:14977143 |
| Li Y et al. | Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai. | 2014 Sep-Oct | Environ Technol | pmid:25145170 |
| Lalman JA and Komjarova I | Impact of long chain fatty acids on glucose fermentation under mesophilic conditions. | 2004 | Environ Technol | pmid:15214444 |
| Zhou Y et al. | An oxygen slow-releasing material and its application in water remediation as oxygen supplier. | 2017 | Environ Technol | pmid:28041538 |
| Galperin MY | Social bacteria and asocial eukaryotes. | 2008 | Environ. Microbiol. | pmid:18199122 |
| De Weirdt R et al. | Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. | 2017 | Environ. Microbiol. | pmid:27883264 |
| Guo J et al. | Phenolic molding compound filled with nonmetals of waste PCBs. | 2008 | Environ. Sci. Technol. | pmid:18284173 |
| Petridis L et al. | Spatial arrangement of organic compounds on a model mineral surface: implications for soil organic matter stabilization. | 2014 | Environ. Sci. Technol. | pmid:24328330 |
| Jin F et al. | Oxidation reaction of high molecular weight carboxylic acids in supercritical water. | 2003 | Environ. Sci. Technol. | pmid:12901673 |
| Ferreira JA et al. | Hydrophobic interactions between spin-label 5-SASL and humic acid as revealed by ESR spectroscopy. | 2001 | Environ. Sci. Technol. | pmid:11349289 |
| Patelski J et al. | Effect of substrate composition and concentration on aortic cholesterol ester hydrolase activity. | 1978 | Enzyme | pmid:25174 |
| Morinaga N et al. | Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. | 2011 | Enzyme Microb. Technol. | pmid:22113022 |
| Leak RE and Woodford JD | Pharmaceutical development of ondansetron tablets. | 1989 | Eur J Cancer Clin Oncol | pmid:2533901 |
| Kelly FD et al. | Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status. | 2002 | Eur J Clin Nutr | pmid:12032647 |
| Tholstrup T et al. | Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. | 2003 | Eur J Clin Nutr | pmid:12792657 |
| Li D et al. | Plasma coagulation factor VII activity and its correlates in healthy men. | 2005 | Eur J Clin Nutr | pmid:16106263 |
| Brown KM et al. | Erythrocyte membrane fatty acid composition of smokers and non-smokers: effects of vitamin E supplementation. | 1998 | Eur J Clin Nutr | pmid:9505161 |
| Zock PL et al. | Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. | 1993 | Eur J Clin Nutr | pmid:8365385 |
| Gebauer SK et al. | Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men. | 2014 | Eur J Clin Nutr | pmid:24736679 |
| Tuomasjukka S et al. | Stearic acid is well absorbed from short- and long-acyl-chain triacylglycerol in an acute test meal. | 2007 | Eur J Clin Nutr | pmid:17299476 |
| Liu L et al. | Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. | 2016 | Eur J Clin Nutr | pmid:26733041 |
| Kelly FD et al. | A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. | 2001 | Eur J Clin Nutr | pmid:11305631 |
| Serebryakova MV et al. | Mass spectrometric sequencing and acylation character analysis of C-terminal anchoring segment from Influenza A hemagglutinin. | 2006 | Eur J Mass Spectrom (Chichester) | pmid:16531651 |
| Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
| Tay T et al. | Dissolution of a poorly water-soluble drug dry coated with magnesium and sodium stearate. | 2012 | Eur J Pharm Biopharm | pmid:22036990 |
| Georget DM et al. | A study on maize proteins as a potential new tablet excipient. | 2008 | Eur J Pharm Biopharm | pmid:18294824 |
| Hu FQ et al. | Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. | 2008 | Eur J Pharm Biopharm | pmid:17997293 |
| Uchimoto T et al. | A comparative study of glycerin fatty acid ester and magnesium stearate on the dissolution of acetaminophen tablets using the analysis of available surface area. | 2011 | Eur J Pharm Biopharm | pmid:21284955 |
| Musiał W and Kubis A | Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum. | 2003 | Eur J Pharm Biopharm | pmid:12637103 |
| Jedinger N et al. | Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids. | 2015 | Eur J Pharm Biopharm | pmid:25733499 |
| Kuno Y et al. | Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol. | 2008 | Eur J Pharm Biopharm | pmid:18396020 |
| Vercruysse J et al. | Use of a continuous twin screw granulation and drying system during formulation development and process optimization. | 2015 | Eur J Pharm Biopharm | pmid:25528462 |
| Podczeck F and Newton JM | Powder and capsule filling properties of lubricated granulated cellulose powder. | 2000 | Eur J Pharm Biopharm | pmid:11072194 |
| Kang JH et al. | Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). | 2012 | Eur J Pharm Biopharm | pmid:22119666 |
| Vervaeck A et al. | Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. | 2015 | Eur J Pharm Biopharm | pmid:26428938 |
| Vervaeck A et al. | Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms. | 2013 | Eur J Pharm Biopharm | pmid:23474381 |
| van Veen B et al. | Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose. | 2005 | Eur J Pharm Biopharm | pmid:15567310 |
| Vueba ML et al. | Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets. | 2004 | Eur J Pharm Biopharm | pmid:15207537 |
| Wong HL et al. | In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. | 2007 | Eur J Pharm Biopharm | pmid:17156986 |
| Baki G et al. | Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets. | 2010 | Eur J Pharm Biopharm | pmid:19931611 |
| Roblegg E et al. | Development of lipophilic calcium stearate pellets using ibuprofen as model drug. | 2010 | Eur J Pharm Biopharm | pmid:20080179 |
| Abdel-Mottaleb MM et al. | Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers. | 2011 | Eur J Pharm Biopharm | pmid:21558002 |
| Lachiver ED et al. | Agglomeration tendency in dry pharmaceutical granular systems. | 2006 | Eur J Pharm Biopharm | pmid:16797949 |
| Davies PN et al. | The determination of the mechanical strength of tablets of different shapes. | 2007 | Eur J Pharm Biopharm | pmid:17329086 |
| Roblegg E et al. | Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. | 2011 | Eur J Pharm Biopharm | pmid:21801834 |
| Wu J et al. | Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with beta-cyclodextrin. | 2001 | Eur J Pharm Biopharm | pmid:11154905 |
| Dudhipala N and Veerabrahma K | Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation. | 2017 | Eur J Pharm Biopharm | pmid:27810472 |
| Voinovich D et al. | Melt pelletization in high shear mixer using a hydrophobic melt binder: influence of some apparatus and process variables. | 2001 | Eur J Pharm Biopharm | pmid:11677073 |
| Wang J et al. | Lubrication in tablet formulations. | 2010 | Eur J Pharm Biopharm | pmid:20096779 |
| Ghate VM et al. | Nanostructured lipid carriers for the topical delivery of tretinoin. | 2016 | Eur J Pharm Biopharm | pmid:27519827 |
| Lippacher A et al. | Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties. | 2002 | Eur J Pharm Biopharm | pmid:11879997 |
| Noor NM et al. | Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery. | 2017 | Eur J Pharm Biopharm | pmid:28412472 |
| Ebba F et al. | Stress relaxation studies of granules as a function of different lubricants. | 2001 | Eur J Pharm Biopharm | pmid:11522488 |
| Fini A et al. | Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. | 2008 | Eur J Pharm Biopharm | pmid:18621516 |
| Bolhuis GK et al. | Compaction properties of isomalt. | 2009 | Eur J Pharm Biopharm | pmid:19327398 |
| Vighi E et al. | Re-dispersible cationic solid lipid nanoparticles (SLNs) freeze-dried without cryoprotectors: characterization and ability to bind the pEGFP-plasmid. | 2007 | Eur J Pharm Biopharm | pmid:17368876 |
| Shao Q et al. | Comparison of neurofuzzy logic and decision trees in discovering knowledge from experimental data of an immediate release tablet formulation. | 2007 | Eur J Pharm Sci | pmid:17459671 |
| Shao Q et al. | Investigation of an artificial intelligence technology--Model trees. Novel applications for an immediate release tablet formulation database. | 2007 | Eur J Pharm Sci | pmid:17452096 |
| Aling J and Podczeck F | The filling of powdered herbs into two-piece hard capsules using hydrogenated cotton seed oil as lubricant. | 2012 | Eur J Pharm Sci | pmid:22960627 |
| Qu L et al. | Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. | 2015 | Eur J Pharm Sci | pmid:26215464 |
| Järvinen K et al. | In-line monitoring of the drug content of powder mixtures and tablets by near-infrared spectroscopy during the continuous direct compression tableting process. | 2013 | Eur J Pharm Sci | pmid:23313622 |
| Wu PC et al. | Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. | 2003 | Eur J Pharm Sci | pmid:12791413 |
| Salazar J et al. | Application of the combinative particle size reduction technology H 42 to produce fast dissolving glibenclamide tablets. | 2013 | Eur J Pharm Sci | pmid:23587645 |