stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Brain Edema D001929 20 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Seizures D012640 87 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
McGee R and Spector AA Fatty acid biosynthesis in Erlich cells. The mechanism of short term control by exogenous free fatty acids. 1975 J. Biol. Chem. pmid:237919
Chien JL and Hogan EL Novel pentahexosyl ganglioside of the globo series purified from chicken muscle. 1983 J. Biol. Chem. pmid:6885798
Fujimoto T et al. P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. 1993 J. Biol. Chem. pmid:7684381
DEYKIN D and GOODMAN DS The hydrolysis of long-chain fatty acid esters of cholesterol with rat liver enzymes. 1962 J. Biol. Chem. pmid:14027461
DeGeorge JJ et al. Acetylcholine stimulates selective liberation and re-esterification of arachidonate and accumulation of inositol phosphates and glycerophosphoinositol in C62B glioma cells. 1987 J. Biol. Chem. pmid:3110145
Muszbek L and Laposata M Myristoylation of proteins in platelets occurs predominantly through thioester linkages. 1993 J. Biol. Chem. pmid:8463334
Ting TC et al. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. 2011 J. Biol. Chem. pmid:21596756
Seeliger JC et al. Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. 2012 J. Biol. Chem. pmid:22194604
Reverey H et al. Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). 1996 J. Biol. Chem. pmid:8798573
TOVE SB et al. Turnover of palmitic, stearic, and unsaturated fatty acids in rat liver. 1956 J. Biol. Chem. pmid:13278335
MEAD JF et al. Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. 1956 J. Biol. Chem. pmid:13278347
Broekman MJ et al. Fatty acid composition of phosphatidylinositol and phosphatidic acid in stimulated platelets. Persistence of arachidonyl-stearyl structure. 1981 J. Biol. Chem. pmid:6790536
Koroly MJ and Conner RL Unsaturated fatty acid biosynthesis in Tetrahymena. Evidence for two pathways. 1976 J. Biol. Chem. pmid:826532
CONIGLIO JG and CATE DL The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. 1958 J. Biol. Chem. pmid:13549425
Björkhem I On the mechanism of regulation of omega oxidation of fatty acids. 1976 J. Biol. Chem. pmid:956185
Sampath H et al. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. 2007 J. Biol. Chem. pmid:17127673
Plötz BM et al. Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid a of the lipopolysaccharide from the hyperthermophilic bacterium Aquifex pyrophilus. 2000 J. Biol. Chem. pmid:10753930
Kole HK et al. A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling. 1996 J. Biol. Chem. pmid:8940181
Richieri GV et al. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. 1994 J. Biol. Chem. pmid:7929039
Hong SL and Deykin D Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin. 1982 J. Biol. Chem. pmid:6806265
Armoni M et al. Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements. 2005 J. Biol. Chem. pmid:16096283
Vitturi DA et al. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. 2013 J. Biol. Chem. pmid:23878198
Ong DE et al. Acyl-CoA-independent esterification of retinol bound to cellular retinol-binding protein (type II) by microsomes from rat small intestine. 1987 J. Biol. Chem. pmid:3818619
Paumen MB et al. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. 1997 J. Biol. Chem. pmid:9013572
Slomiany A et al. Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. 1983 J. Biol. Chem. pmid:6863300
Liang X et al. Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. 2002 J. Biol. Chem. pmid:12105219
Liang X et al. Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. 2001 J. Biol. Chem. pmid:11423543
Lee W et al. Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. 2013 J. Biol. Chem. pmid:23306194
Ogata S et al. Chemical characterization of the membrane-anchoring domain of human placental alkaline phosphatase. 1988 J. Biol. Chem. pmid:3392021
Doering TL et al. Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. 1993 J. Biol. Chem. pmid:8486622
Moehren G et al. Activation and desensitization of phospholipase D in intact rat hepatocytes. 1994 J. Biol. Chem. pmid:8288637
Christian F et al. Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. 2011 J. Biol. Chem. pmid:21177871
Townsend LE et al. In vitro acylation of rat brain myelin proteolipid protein. 1982 J. Biol. Chem. pmid:7107590
HOLLOWAY PW and WAKIL SJ SYNTHESIS OF FATTY ACIDS IN ANIMAL TISSUES. II. THE OCCURRENCE AND BIOSYNTHESIS OF CIS-VACCENIC ACID. 1964 J. Biol. Chem. pmid:14235526
WEINMAN EO et al. Conversion of first and sixth carbons of stearic acid to carbon dioxide by rats. 1951 J. Biol. Chem. pmid:14861197
DAVIDOFF F and KORN ED THE CONVERSION OF LONG CHAIN SATURATED FATTY ACIDS TO THEIR ALPHA, BETA-UNSATURATED, BETA, GAMMA-UNSATURATED, AND BETA-HYDROXY DERIVATIVES BY ENZYMES FROM THE CELLULAR SLIME MOLD, DICTYOSTELIUM DISCOIDEUM. 1964 J. Biol. Chem. pmid:14235527
Hope MJ and Cullis PR Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. 1987 J. Biol. Chem. pmid:3558410
Kolesnick RN and Paley AE 1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action. 1987 J. Biol. Chem. pmid:3597411
Leonardi R et al. Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis. 2009 J. Biol. Chem. pmid:19666474
Habenicht AJ et al. Cell cycle-dependent changes in arachidonic acid and glycerol metabolism in Swiss 3T3 cells stimulated by platelet-derived growth factor. 1985 J. Biol. Chem. pmid:3918038
Hsia JC and Kwan NH Human serum albumin: binding specificity and allosteric effect of parinarate and stearate. A dianionic spin label study. 1981 J. Biol. Chem. pmid:6257712
KANFER J OBSERVATIONS ON CEREBROSIDE METABOLISM IN VIVO. 1965 J. Biol. Chem. pmid:14275111
Petrescu AD et al. Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity. 2005 J. Biol. Chem. pmid:15741159
BACHUR NR et al. FATTY ACID AMIDES OF ETHANOLAMINE IN MAMMALIAN TISSUES. 1965 J. Biol. Chem. pmid:14284696
Abumrad NA et al. Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. 1984 J. Biol. Chem. pmid:6746632
Pahuja SL and Hochberg RB A comparison of the fatty acid esters of estradiol and corticosterone synthesized by tissues of the rat. 1989 J. Biol. Chem. pmid:2492532
Wang G et al. Phosphatidylcholines with sn-1 saturated and sn-2 cis-monounsaturated acyl chains. Their melting behavior and structures. 1995 J. Biol. Chem. pmid:7559399
TIETZ A et al. A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS. 1964 J. Biol. Chem. pmid:14247652
OVERATH P and STUMPF PK FAT METABOLISM IN HIGHER PLANTS. 23. PROPERTIES OF A SOLUBLE FATTY ACID SYNTHETASE FROM AVOCADO MESOCARP. 1964 J. Biol. Chem. pmid:14247655
FULCO AJ and BLOCH K COFACTOR REQUIREMENTS FOR THE FORMATION OF DELTA-9-UNSATURATED FATTY ACIDS IN MYCOBACTERIUM PHLEI. 1964 J. Biol. Chem. pmid:14167617
HULANICKA D et al. LIPID METABOLISM OF EUGLENA GRACILIS. 1964 J. Biol. Chem. pmid:14216427
Masuoka HC et al. Mcl-1 degradation during hepatocyte lipoapoptosis. 2009 J. Biol. Chem. pmid:19734538
FULCO AJ et al. THE BIOSYNTHESIS OF DELTA-9 AND DELTA-5-MONOSATURATED FATTY ACIDS BY BACTERIA. 1964 J. Biol. Chem. pmid:14167618
Dixon JF and Hokin LE Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase. 1984 J. Biol. Chem. pmid:6438097
KORN ED FATTY ACIDS OF ACANTHAMOEBA SP. 1963 J. Biol. Chem. pmid:14109190
Thompson W and MacDonald G Isolation and characterization of cytidine diphosphate diglyceride from beef liver. 1975 J. Biol. Chem. pmid:169258
Morrisett JD et al. Multiple thermotropic phase transitions in Escherichia coli membranes and membrane lipids. A comparison of results obtained by nitroxyl stearate paramagnetic resonance, pyrene excimer fluorescence, and enzyme activity measurements. 1975 J. Biol. Chem. pmid:169264
BJOERNTORP P et al. ALBUMIN ANTAGONISM OF FATTY ACID EFFECTS ON OXIDATION AND PHOSPHORYLATION REACTIONS IN RAT LIVER MITOCHONDRIA. 1964 J. Biol. Chem. pmid:14114863
BENJAMIN W and GELLHORN A THE EFFECT OF DIABETES AND INSULIN ON THE BIOSYNTHESIS OF INDIVIDUAL FATTY ACIDS IN ADIPOSE TISSUE. 1964 J. Biol. Chem. pmid:14114873
LEVIS GM and MEAD JF AN ALPHA-HYDROXY ACID DECARBOXYLASE IN BRAIN MICROSOMES. 1964 J. Biol. Chem. pmid:14114875
FUTTERMAN S and ANDREWS JS METABOLISM OF THE RETINA. IV. THE COMPOSITION OF VITAMIN A ESTER SYNTHESIZED BY THE RETINA. 1964 J. Biol. Chem. pmid:14114876
PREISS B and BLOCH K OMEGA-OXIDATION OF LONG CHAIN FATTY ACIDS IN RAT LIVER. 1964 J. Biol. Chem. pmid:14114877
Thomas CP et al. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. 2010 J. Biol. Chem. pmid:20061396
Larner JM et al. The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. 1993 J. Biol. Chem. pmid:8314757
Agrawal HC et al. In vivo incorporation of [3H]palmitic acid into PO protein, the major intrinsic protein of rat sciatic nerve myelin. 1983 J. Biol. Chem. pmid:6189827
Mironova GD et al. Palmitic and stearic acids bind Ca2+ with high affinity and form nonspecific channels in black-lipid membranes. Possible relation to Ca2+-activated mitochondrial pores. 2001 J. Bioenerg. Biomembr. pmid:11710807
YashRoy RC Protein heat denaturation and study of membrane lipid-protein interactions by spin label ESR. 1991 J. Biochem. Biophys. Methods pmid:1848569
Gotoh K et al. Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. 1986 J. Biochem. pmid:2880840
Kushi Y et al. Comparative study of acidic glycosphingolipids by field desorption and secondary ion mass spectrometry. 1983 J. Biochem. pmid:6671968
Muriana FJ et al. Lipid and fatty acid composition of hepatopancreatic brush-border membrane vesicles from the prawn Penaeus japonicus. 1993 J. Biochem. pmid:8340355
Ogata S et al. Chemical identification of lipid components in the membranous form of rat liver alkaline phosphatase. 1987 J. Biochem. pmid:2834351
Tanaka H et al. In situ observation of bovine serum albumin-adsorbed stearic acid monolayer by Brewster angle microscopy. 1997 J. Biochem. pmid:9089391
Ito Y et al. Fatty acid synthetase as a thermoreceptor in Candida utilis. 1986 J. Biochem. pmid:3745143
Sugimoto Y et al. A 2H NMR study on alteration of the membrane organization of mouse B16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate. 1986 J. Biochem. pmid:3818567
WAKU K and NAKAZAWA Y ON THE LIPIDS OF RABBIT SARCOPLASMIC RETICULUM. 1964 J. Biochem. pmid:14202242
Fujii H and Kakinuma K Studies on the superoxide releasing site in plasma membranes of neutrophils with ESR spin-labels. 1990 J. Biochem. pmid:2172228
Hyono A et al. ESR studies on the membrane properties of a moderately halophilic bacterium. I. Physical properties of lipid bilayers in whole cells. 1980 J. Biochem. pmid:6257661
Sugita M et al. Studies on glycosphingolipids of fresh-water bivalves. VI. Isolation and chemical characterization of neutral glycosphingolipids from spermatozoa of the fresh-water bivalve, Hyriopsis schlegelii. 1981 J. Biochem. pmid:7338520
Tanaka H et al. Morphology of a cytochrome c-adsorbed stearic acid monolayer on Brewster angle microscopy. 1995 J. Biochem. pmid:7490253
Wada H et al. In vitro ferredoxin-dependent desaturation of fatty acids in cyanobacterial thylakoid membranes. 1993 J. Bacteriol. pmid:8419301
JOHNSON RC and GARY ND NUTRITION OF LEPTOSPIRA POMONA. II. FATTY ACID REQUIREMENTS. 1963 J. Bacteriol. pmid:14044026
Wada M et al. Mechanism of biosynthesis of unsaturated fatty acids in Pseudomonas sp. strain E-3, a psychrotrophic bacterium. 1989 J. Bacteriol. pmid:2753856
POLAN CE et al. BIOHYDROGENATION OF UNSATURATED FATTY ACIDS BY RUMEN BACTERIA. 1964 J. Bacteriol. pmid:14219019
Nonogaki T et al. Developmental blockage of mouse embryos caused by fatty acids. 1994 J. Assist. Reprod. Genet. pmid:7633171
Mougios V et al. Duration of coffee- and exercise-induced changes in the fatty acid profile of human serum. 2003 J. Appl. Physiol. pmid:12391036
Mohsenin V and Gee JL Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. 1989 J. Appl. Physiol. pmid:2787317
Jarvis GN et al. Isolation and characterization of two glycerol-fermenting clostridial strains from a pilot scale anaerobic digester treating high lipid-content slaughterhouse waste. 1999 J. Appl. Microbiol. pmid:10196746
Paillard D et al. Quantification of ruminal Clostridium proteoclasticum by real-time PCR using a molecular beacon approach. 2007 J. Appl. Microbiol. pmid:17897229
Pniewski T et al. Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation. 2011 J. Appl. Genet. pmid:21107787
Anderson R et al. Studies on the effects of ingestion of a single 500 mg oral dose of erythromycin stearate on leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. 1984 J. Antimicrob. Chemother. pmid:6592163
Shanson DC Antibiotic prophylaxis of infective endocarditis in the United Kingdom and Europe. 1987 J. Antimicrob. Chemother. pmid:3119557
Malmborg AS Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. 1979 J. Antimicrob. Chemother. pmid:500517
Korkeala H and Männistö PT Time course of the antibacterial activity of erythromycin stearate and erythromycin acistrate against two Staphylococcus aureus strains in vitro. 1988 J. Antimicrob. Chemother. pmid:3182415
Salo OP et al. Efficacy and tolerability of erythromycin acistrate and erythromycin stearate in acute skin infections of patients with atopic eczema. 1988 J. Antimicrob. Chemother. pmid:3391871
Rostila T et al. Erythromycin acistrate and erythromycin stearate in the treatment of non-gonococcal urethritis. 1988 J. Antimicrob. Chemother. pmid:3391873
Männistö PT et al. Fate of single oral doses of erythromycin acistrate, erythromycin stearate and pelleted erythromycin base analysed by mass-spectrometry in plasma of healthy human volunteers. 1988 J. Antimicrob. Chemother. pmid:3391874
Savolainen S et al. Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis. 1988 J. Antimicrob. Chemother. pmid:3391878
Viluksela M et al. Comparative liver toxicity of various erythromycin derivatives in animals. 1988 J. Antimicrob. Chemother. pmid:3391880
McNulty CA et al. Inhibitory antimicrobial concentrations against Campylobacter pylori in gastric mucosa. 1988 J. Antimicrob. Chemother. pmid:3209531
Clarke CW et al. A new formulation of erythromycin stearate: blood and sputum levels in patients with chronic lower respiratory tract infection. 1980 J. Antimicrob. Chemother. pmid:7400071