stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Brain Edema D001929 20 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Seizures D012640 87 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Turpeinen AM et al. Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9484999
Prasad MR et al. Regional membrane phospholipid alterations in Alzheimer's disease. 1998 Neurochem. Res. pmid:9482271
Zerbini E et al. [Characterization of fatty acids and mycolic acid degradation products in mycobacterial species of major incidence in Argentina]. 1997 Oct-Dec Rev. Argent. Microbiol. pmid:9472140
Ali S et al. Acyl chain-length asymmetry alters the interfacial elastic interactions of phosphatidylcholines. 1998 Biophys. J. pmid:9449334
Coulomb B et al. Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/IL-6 ratio. 1997 Skin Pharmacol. pmid:9449167
Jono K et al. Effect of additives on dissolution and swelling of soybean lecithin microcapsules prepared using the Wurster process. 1997 Chem. Pharm. Bull. pmid:9433778
Miyamoto M et al. Design and preparation of gadolinium-reservoir microcapsules for neutron-capture therapy by means of the Wurster process. 1997 Chem. Pharm. Bull. pmid:9433776
Storm H et al. Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. 1997 Diabetes Care pmid:9405898
Ali I and Steele JE Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. 1997 Insect Biochem. Mol. Biol. pmid:9404012
Pérez FR et al. cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells. Suggestion for a direct cis-FFA perturbation of the Ca2+ channel opening. 1997 Biochim. Biophys. Acta pmid:9371418
Kogure K et al. Effect of dicetylphosphate or stearic acid on spontaneous transfer of protein from influenza virus-infected cells to dimyristoylphosphatidylcholine liposomes. 1997 Biochim. Biophys. Acta pmid:9370255
Piel J et al. Cellulysin from the plant parasitic fungus Trichoderma viride elicits volatile biosynthesis in higher plants via the octadecanoid signalling cascade. 1997 FEBS Lett. pmid:9369200
Ali I and Steele JE Fatty acids stimulate trehalose synthesis in trophocytes of the cockroach (Periplaneta americana) fat body. 1997 Gen. Comp. Endocrinol. pmid:9356224
Neubert R et al. Structure of stratum corneum lipids characterized by FT-Raman spectroscopy and DSC. II. Mixtures of ceramides and saturated fatty acids. 1997 Chem. Phys. Lipids pmid:9353900
Dürig T and Fassihi R Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended-release formulation. 1997 J Pharm Sci pmid:9344163
Yamashita T et al. [Studies on erythromycin stearate capsules (OE-7) (author's transl)]. 1976 Jpn J Antibiot pmid:933342
Bondarenko LB et al. Fatty acids hydroxamic derivatives as inhibitors of 5-lipoxygenase. 1997 Adv. Exp. Med. Biol. pmid:9321992
West RR and Stafford DA Occupational exposures and haematological abnormalities among ordnance factory workers: a case control study. 1997 Leuk. Res. pmid:9301689
Moers A and Schrezenmeir J Palmitic acid but not stearic acid inhibits NO-production in endothelial cells. 1997 Exp. Clin. Endocrinol. Diabetes pmid:9288552
Wagner K et al. Influence of duodenal infusion of nicotinic acid on the milk fat composition of dairy cows. 1997 Arch Tierernahr pmid:9272222
Alvarez-Ortega R et al. Characterization of polar and nonpolar seed lipid classes from highly saturated fatty acid sunflower mutants. 1997 Lipids pmid:9270974
Sparks JD et al. Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. 1997 Biochim. Biophys. Acta pmid:9233686
Khomutov GB et al. Interaction of copper ions with stearic acid Langmuir monolayers and formation of cluster structures in monolayers and Langmuir-Blodgett films. 1997 Membr Cell Biol pmid:9231365
Yamamoto A and Kawashima Y Perfluorodecanoic acid enhances the formation of oleic acid in rat liver. 1997 Biochem. J. pmid:9230124
Dhillon HS et al. Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. 1997 Exp. Neurol. pmid:9225757
Noker PE et al. Metabolism of 14C-labelled sucrose esters of stearic acid in rats. 1997 Food Chem. Toxicol. pmid:9225017
Clandinin MT et al. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. 1997 Biochim. Biophys. Acta pmid:9219909
Williams JP et al. Regulation of osteoclastic bone resorption by glucose. 1997 Biochem. Biophys. Res. Commun. pmid:9207213
Hassel CA et al. Dietary stearic acid reduces plasma and hepatic cholesterol concentrations without increasing bile acid excretion in cholesterol-fed hamsters. 1997 J. Nutr. pmid:9187629
Fellner V et al. Effect of nigericin, monensin, and tetronasin on biohydrogenation in continuous flow-through ruminal fermenters. 1997 J. Dairy Sci. pmid:9178132
Vorum H et al. Palmitate and stearate binding to human serum albumin. Determination of relative binding constants. 1997 J. Pept. Res. pmid:9176819
Wang H et al. Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. 1997 Am. J. Physiol. pmid:9176199
Di Pierro D et al. Separation of representative lipid compounds of biological membranes and lipid derivatives from peroxidized polyunsaturated fatty acids by reversed phase high-performance liquid chromatography. 1997 Free Radic. Res. pmid:9167935
Frohlich BT et al. Formation and cell-medium partitioning of autoinhibitory free fatty acids and cyclodextrin's effect in the cultivation of Bordetella pertussis. 1996 J. Biotechnol. pmid:9147447
Aro A et al. Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9129471
Gonzalez-Castro MY et al. Effects of blanching, freezing and freeze-drying on the fatty acid contents of green beans. 1996 Z Lebensm Unters Forsch pmid:9123974
Yamashita T and Tsubura E [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. 1977 Jpn J Antibiot pmid:909141
Tanaka H et al. In situ observation of bovine serum albumin-adsorbed stearic acid monolayer by Brewster angle microscopy. 1997 J. Biochem. pmid:9089391
Pai T and Yeh YY Stearic acid modifies very low density lipoprotein lipid composition and particle size differently from shorter-chain saturated fatty acids in cultured rat hepatocytes. 1997 Lipids pmid:9075203
Hussey HJ and Tisdale MJ Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). 1997 Br. J. Cancer pmid:9062405
Pacini L et al. Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. 1997 J. Neurooncol. pmid:9049841
Murthy KS and Samyn JC Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants. 1977 J Pharm Sci pmid:903855
Brun T et al. Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. 1997 Diabetes pmid:9032094
Mutanen M and Aro A Coagulation and fibrinolysis factors in healthy subjects consuming high stearic or trans fatty acid diets. 1997 Thromb. Haemost. pmid:9031457
Staprans I et al. Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. 1996 J. Lipid Res. pmid:9026539
Mizushima H et al. Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol. 1996 J. Lipid Res. pmid:9026533
Rhee SK et al. Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins. 1997 Am. J. Clin. Nutr. pmid:9022530
Kleinschmidt JH et al. Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study. 1997 Biophys. J. pmid:9017202
Paumen MB et al. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. 1997 J. Biol. Chem. pmid:9013572
Santos MJ et al. Influence of dietary fish on fatty acid composition of the erythrocyte membrane in coronary heart disease patients. 1996 Int J Vitam Nutr Res pmid:8979167