| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Erectile Dysfunction | D007172 | 19 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Seizures | D012640 | 87 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| FLEMMING K | RADIATION PROTECTIVE EFFECT AND PHARMACOLOGICALLY CHANGED ACTIVITY OF THE RETICULO-ENDOTHELIAL SYSTEM. | 1963 | Nature | pmid:14098457 |
| SHORE PA and ALPERS HS | PLATELET DAMAGE INDUCED IN PLASMA BY CERTAIN FATTY ACIDS. | 1963 | Nature | pmid:14098491 |
| Senyilmaz D et al. | Regulation of mitochondrial morphology and function by stearoylation of TFR1. | 2015 | Nature | pmid:26214738 |
| VROMAN L and LUKOSEVICIUS A | ELLIPSOMETER RECORDINGS OF CHANGES IN OPTICAL THICKNESS OF ADSORBED FILMS ASSOCIATED WITH SURFACE ACTIVATION OF BLOOD CLOTTING. | 1964 | Nature | pmid:14236308 |
| SPINK JA | Structure of stearic acid films on copper. | 1950 | Nature | pmid:15416726 |
| Arici M et al. | Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C. | 2002 | Nephrol. Dial. Transplant. | pmid:12270980 |
| Gault MH et al. | Heparin, fatty acids and sodium, potassium-ATPase inhibition by plasma factors during hemodialysis. | 1992 | Nephron | pmid:1314335 |
| Politi LE et al. | Dexamethasone effect on free fatty acid and diacylglycerol accumulation during experimentally induced vasogenic brain edema. | 1985 | Neurochem Pathol | pmid:3831846 |
| Boiron F et al. | A comparison of substrate-dependent fatty acyl-CoA synthetase activities and ATP hydrolysis in membrane pellets from normal and trembler mouse sciatic nerves. | 1985 | Neurochem. Int. | pmid:20492990 |
| Samochocki M and Strosznajder J | Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes. | 1993 | Neurochem. Int. | pmid:8220171 |
| Shih JC and Ohsawa R | Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites. | 1983 | Neurochem. Res. | pmid:6621769 |
| Messier AM and Bizzozero OA | Conserved fatty acid composition of proteolipid protein during brain development and in myelin subfractions. | 2000 | Neurochem. Res. | pmid:10823577 |
| Prasad MR et al. | Regional membrane phospholipid alterations in Alzheimer's disease. | 1998 | Neurochem. Res. | pmid:9482271 |
| LaFontaine MA et al. | 3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease. | 2002 | Neurochem. Res. | pmid:12199156 |
| Mehta JR et al. | Lipid fluidity and composition of the erythrocyte membrane from healthy dogs and Labrador retrievers with hereditary muscular dystrophy. | 1991 | Neurochem. Res. | pmid:1908955 |
| Todorow S and Elies W | [Oily contrast medium in liquor space following myelography. A clinical-radiological study on extent, velocity and ways of elimination of monoiodine stearate]. | 1976 | Neurochirurgia (Stuttg) | pmid:185538 |
| Gabriel SM and Simpkins JW | Effects of a sustained-release naloxone pellet on luteinizing hormone secretion in female rats. | 1983 | Neuroendocrinology | pmid:6139759 |
| Hattori T et al. | Attenuation by pentobarbital of free fatty acid and diacylglycerol liberation during global ischaemia in rat brain. | 1986 | Neurol. Res. | pmid:2871507 |
| Hattori T et al. | Membrane phospholipid composition and membrane fluidity of human brain tumour: a spin label study. | 1987 | Neurol. Res. | pmid:2883605 |
| Beleslin DB et al. | Hyperthermic effect of palmitate sodium, stearate sodium and oleate sodium injected into the cerebral ventricles of conscious cats. | 1974 | Neuropharmacology | pmid:4840846 |
| Patil S and Chan C | Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. | 2005 | Neurosci. Lett. | pmid:15939536 |
| Broderick PA | Distinguishing in vitro electrochemical signatures for norepinephrine and dopamine. | 1988 | Neurosci. Lett. | pmid:3226613 |
| Yang DY et al. | Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. | 2007 | Neurotoxicology | pmid:17854901 |
| Qi B et al. | A Golgi and tonoplast localized S-acyl transferase is involved in cell expansion, cell division, vascular patterning and fertility in Arabidopsis. | 2013 | New Phytol. | pmid:23795888 |
| Nakagawa T et al. | [Design and application of oral sustained-release anticancer drug--a new oral dosage form of cisplatin]. | 1998 | Nippon Rinsho | pmid:9549356 |
| Nyblom HK et al. | Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids. | 2008 | NMR Biomed | pmid:17691080 |
| Teyssier G et al. | [Adult-type respiratory distress syndrome in children. Course of the palmitic acid/stearic acid ratio in tracheal aspirations]. | 1981 | Nouv Presse Med | pmid:7290945 |
| Sabbah A | [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. | 1976 | Nouv Presse Med | pmid:1264643 |
| Beckurts TE et al. | Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo. | 1985 | Nucl Med Commun | pmid:4047532 |
| Sobal G et al. | Uptake of 99mTc-labeled chondroitin sulfate by chondrocytes and cartilage: a promising agent for imaging of cartilage degeneration? | 2009 | Nucl. Med. Biol. | pmid:19181270 |
| Golubić M et al. | Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids. | 1998 | Nutr Cancer | pmid:9589427 |
| Evans LM et al. | Stearate preferentially induces apoptosis in human breast cancer cells. | 2009 | Nutr Cancer | pmid:19838949 |
| Nelson B et al. | Effect of Dietary-Resistant Starch on Inhibition of Colonic Preneoplasia and Wnt Signaling in Azoxymethane-Induced Rodent Models. | Nutr Cancer | pmid:27367460 | |
| Dancey CP et al. | Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449]. | 2006 | Nutr J | pmid:16762076 |
| Naidu KA | Vitamin C in human health and disease is still a mystery? An overview. | 2003 | Nutr J | pmid:14498993 |
| Oosterveer MH et al. | Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function. | 2011 | Nutr Metab (Lond) | pmid:22201701 |
| Ding EL et al. | Chocolate and prevention of cardiovascular disease: a systematic review. | 2006 | Nutr Metab (Lond) | pmid:16390538 |
| Karupaiah T and Sundram K | Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications. | 2007 | Nutr Metab (Lond) | pmid:17625019 |
| van den Berg SA et al. | High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity. | 2010 | Nutr Metab (Lond) | pmid:20346174 |
| Wang L et al. | Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | 2003 | Nutr Metab Cardiovasc Dis | pmid:14717057 |
| Ash MM et al. | Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters. | 2011 | Nutr Res | pmid:21840470 |
| Castellanos-Tapia L et al. | Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. | 2015 | Nutr Res | pmid:25727313 |
| Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
| Choi SE et al. | Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. | 2011 | Nutr Res | pmid:21745629 |
| Park MY et al. | Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice. | 2011 | Nutr Res Pract | pmid:22259675 |
| Berry SE | Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease. | 2009 | Nutr Res Rev | pmid:19442321 |
| POLYOXYETHYLENE stearates in food. | 1955 | Nutr. Rev. | pmid:14394517 | |
| Cerf ME and Herrera E | High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. | 2016 | Nutrients | pmid:26742067 |
| Wong RH et al. | Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. | 2012 | Nutrients | pmid:22690320 |
| Peck MD et al. | Fatty acid unsaturation increases expression and capping of murine lymphocyte CD44 and CD45. | 1996 | Nutrition | pmid:8878171 |