| MeSH term | MeSH ID | Detail |
|---|---|---|
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wenzel DG and Kleoppel JW | Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. | 1980 | Toxicology | pmid:7210021 |
| Nohynek GJ et al. | Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. | 2006 | Toxicol. Lett. | pmid:16243460 |
| Mitra A et al. | Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. | 1992 | Toxicol. Lett. | pmid:1595087 |
| Salminen S and Salminen E | Urinary excretion of orally administered oxalic acid in MYRJ 45-treated NMRI mice. | 1987 | Toxicol. Lett. | pmid:3590233 |
| FITZHUGH OG et al. | Chronic oral toxicities of four stearic acid emulsifiers. | 1959 | Toxicol. Appl. Pharmacol. | pmid:13659539 |
| Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26739624 |
| Simon MN et al. | Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. | 2008 | Toxicol In Vitro | pmid:18395405 |
| Abdel-Hameid NA | Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats. | 2007 | Toxicol In Vitro | pmid:17267170 |
| Simon C et al. | Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. | 2016 | Toxicol In Vitro | pmid:27633901 |
| Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |