stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Dermatitis D003872 30 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Hyperlipidemias D006949 73 associated lipids
Bronchitis D001991 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Woldseth B et al. Monounsaturated trans fatty acids, elaidic acid and trans-vaccenic acid, metabolism and incorporation in phospholipid molecular species in hepatocytes. 1998 Scand. J. Clin. Lab. Invest. pmid:10088200
Kalm O et al. Erythromycin stearate in acute maxillary sinusitis. 1975 Scand. J. Infect. Dis. pmid:241119
Heimdahl A and Nord CE Influence of erythromycin on the normal human flora and colonization of the oral cavity, throat and colon. 1982 Scand. J. Infect. Dis. pmid:7071527
Eriksson M et al. Absorption of erythromycin from pediatric suspension in infants and children. 1981 Scand. J. Infect. Dis. pmid:7313575
Kaukoranta-Tolvanen SS et al. Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora. 1989 Scand. J. Infect. Dis. pmid:2617212
Khan FN and Dehghan MH Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives. 2012 Jan-Mar Sci Pharm pmid:22396916
Pujeri SS et al. Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method. 2012 Jan-Mar Sci Pharm pmid:22396908
Tomuta I et al. High-Throughput NIR-Chemometric Method for Meloxicam Assay from Powder Blends for Tableting. 2011 Oct-Dec Sci Pharm pmid:22145112
Malik K et al. Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets. 2011 Jul-Sep Sci Pharm pmid:21886910
Zaid AN et al. Formulation and bioequivalence of two valsartan tablets after a single oral administration. 2011 Jan-Mar Sci Pharm pmid:21617777
Shah DA et al. Stability indicating LC-method for estimation of paracetamol and lornoxicam in combined dosage form. 2011 Jan-Mar Sci Pharm pmid:21617776
Aburahma MH et al. Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid. 2010 Apr-Jun Sci Pharm pmid:21179352
Singh B et al. Formulation optimization of hydrodynamically balanced oral controlled release bioadhesive tablets of tramadol hydrochloride. 2010 Apr-Jun Sci Pharm pmid:21179349
Chaturvedi K et al. Floating matrix dosage form for propranolol hydrochloride based on gas formation technique: development and in vitro evaluation. 2010 Oct-Dec Sci Pharm pmid:21179326
Nanjwade BK et al. Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs. 2011 Oct-Dec Sci Pharm pmid:22145101
Kaur G et al. Chitosan-carboxymethyl tamarind kernel powder interpolymer complexation: investigations for colon drug delivery. 2010 Jan-Mar Sci Pharm pmid:21179370
Liu Z et al. A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. 2015 Sci Rep pmid:26400022
Miao H et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. 2015 Sci Rep pmid:26271607
Fala AM et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. 2015 Sci Rep pmid:26237540
Li C et al. Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. 2013 Sci Rep pmid:23712069