stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Dermatitis D003872 30 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Hyperlipidemias D006949 73 associated lipids
Bronchitis D001991 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Callaghan R et al. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. 1993 Biochim. Biophys. Acta pmid:8435444
Das T et al. Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. 1993 Eur. J. Biochem. pmid:8436130
Poulos A et al. Fatty acid synthesis from [2-14C]acetate in normal and peroxisome-deficient (Zellweger) fibroblasts. 1993 Lipids pmid:8441343
Derr J et al. The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids. 1993 Metab. Clin. Exp. pmid:8446040
Muszbek L and Laposata M Myristoylation of proteins in platelets occurs predominantly through thioester linkages. 1993 J. Biol. Chem. pmid:8463334
Nishihira J et al. Identification of the hydrophobic ligand-binding region in recombinant glutathione S-transferase P and its binding effect on the conformational state of the enzyme. 1993 Arch. Biochem. Biophys. pmid:8470890
Hamilton KS et al. Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. 1993 Biochemistry pmid:8471610
Hari PR and Sharma CP Protein adsorption--effect of external lubricants at the interface. 1993 J Biomater Appl pmid:8473987
Mensink RP Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. 1993 Am. J. Clin. Nutr. pmid:8475888
Michiels C et al. Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. 1993 Am. J. Physiol. pmid:8476019
el-Sharkawy SH et al. Microbiological transformations of lipids: acyl-specific hydrolysis of lard by yeasts. 1993 Appl. Environ. Microbiol. pmid:8480999
Woldseth B et al. Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. 1993 Biochim. Biophys. Acta pmid:8481391
Doering TL et al. Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. 1993 J. Biol. Chem. pmid:8486622
Mustad VA et al. Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. 1993 Metab. Clin. Exp. pmid:8487669
Sastri MS et al. In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. 1993 Arzneimittelforschung pmid:8489559
Sylvester PW et al. Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation. 1993 Life Sci. pmid:8505862
Melik-Nubarov NS et al. Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. 1993 Biochem. Mol. Biol. Int. pmid:8508145
Cárdenas L et al. Isolation, chemical structures and biological activity of the lipo-chitin oligosaccharide nodulation signals from Rhizobium etli. 1995 Plant Mol. Biol. pmid:8534845
Iskhakova FKh et al. [Synthesis of stearoyl derivatives of proline-containing hydrophobic peptides]. 1995 Bioorg. Khim. pmid:8540900
Singh S et al. Multiple emulsion-based systems carrying insulin: development and characterization. 1995 Nov-Dec J Microencapsul pmid:8558383