stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Bessesen DH et al. Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10827016
Wei Y et al. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16492686
Hodson L et al. Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20628024
Montell E et al. DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11158925
Green CD and Olson LK Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21266672
Kadotani A et al. Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:19755671
Peter A et al. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21045174
Dasu MR and Jialal I Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959532
Subauste AR and Burant CF Role of FoxO1 in FFA-induced oxidative stress in adipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17374693
Bassilian S et al. Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11832351