stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Boiret M et al. Setting local rank constraints by orthogonal projections for image resolution analysis: application to the determination of a low dose pharmaceutical compound. 2015 Anal. Chim. Acta pmid:26388474
Veit M and Siche S S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? 2015 Vaccine pmid:26387429
de Sousa FF et al. Low-temperature phase transformation studies in the stearic acid: C form. 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25909902
Patil H et al. Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. 2015 Int J Pharm pmid:25863118
Bera H et al. Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone. 2015 Int. J. Biol. Macromol. pmid:25861741
Badal Tejedor M et al. Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure. 2015 Int J Pharm pmid:25841569
Rozman Peterka T et al. Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. 2015 J Pharm Biomed Anal pmid:25804434
Kelidari HR et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. 2015 Colloids Surf B Biointerfaces pmid:25797482
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Thakral NK et al. Compression-induced crystallization of amorphous indomethacin in tablets: characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. 2015 Mol. Pharm. pmid:25438193
Liu Z et al. Process optimization and kinetic evaluation for biosynthesis of D-isoascorbyl stearate. 2015 Bioprocess Biosyst Eng pmid:25407728
Askari M et al. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. 2015 Clin Transl Oncol pmid:25351172
Vervaeck A et al. Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. 2015 Eur J Pharm Biopharm pmid:26428938
Mohanty B et al. Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery. 2015 Pharm Dev Technol pmid:24490828
Guadalupe Sánchez-González E et al. The influence of polymorphism on the manufacturability and in vitro dissolution of sulindac-containing hard gelatin capsules. 2015 Pharm Dev Technol pmid:24417644
Van Hoeck V et al. Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations. 2015 Reprod. Fertil. Dev. pmid:24360349
Nandini PT et al. Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles. 2015 Drug Deliv pmid:24283392
Chen Q et al. Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. 2015 Artif Cells Nanomed Biotechnol pmid:24093764
Iwao Y [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. 2015 Yakugaku Zasshi pmid:26423868
Liu Z et al. A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. 2015 Sci Rep pmid:26400022
Miao H et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. 2015 Sci Rep pmid:26271607
Soliman HM et al. Utilization of Stearic acid Extracted from Olive Pomace for Production of Triazoles, Thiadiazoles and Thiadiazines Derivatives of Potential Biological Activities. 2015 J Oleo Sci pmid:26250422
Fala AM et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. 2015 Sci Rep pmid:26237540
Senyilmaz D et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. 2015 Nature pmid:26214738
Gotoh K et al. Introduction of Atmospheric Pressure Plasma to Aqueous Detergent Processes. 2015 J Oleo Sci pmid:26179001
Astanina K et al. Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells. 2015 Sci Rep pmid:26095213
Sasakura D et al. Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy. 2015 Pharmazie pmid:26601418
Li Y et al. Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai. 2014 Sep-Oct Environ Technol pmid:25145170
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Kushner J and Schlack H Commercial scale validation of a process scale-up model for lubricant blending of pharmaceutical powders. 2014 Int J Pharm pmid:25152166
Mateo-Ortiz D et al. Analysis of powder phenomena inside a Fette 3090 feed frame using in-line NIR spectroscopy. 2014 J Pharm Biomed Anal pmid:25128874
Horio T et al. Effect of particle shape on powder flowability of microcrystalline cellulose as determined using the vibration shear tube method. 2014 Int J Pharm pmid:25079435
Yodkhum K and Phaechamud T Hydrophobic chitosan sponges modified by aluminum monostearate and dehydrothermal treatment as sustained drug delivery system. 2014 Mater Sci Eng C Mater Biol Appl pmid:25063173
Han GR and Jang CH Detection of heavy-metal ions using liquid crystal droplet patterns modulated by interaction between negatively charged carboxylate and heavy-metal cations. 2014 Talanta pmid:25059128
Igne B et al. Modeling strategies for pharmaceutical blend monitoring and end-point determination by near-infrared spectroscopy. 2014 Int J Pharm pmid:25003830
Syamala US et al. Assessment of formulation factors on the release behaviour of BCS Class II drug from tablet dosage form using DoE. 2014 Curr Drug Deliv pmid:24975287
Liu J et al. Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles. 2014 Nanoscale pmid:24969040
Tadros MI and Fahmy RH Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. 2014 Int J Pharm pmid:24928130
Evoli S et al. Molecular simulations of β-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites. 2014 Proteins pmid:24916607
Uğurlu T and Halaçoğlu MD Effects of some lubricants and evaluation of compression parameters on directly compressible powders. 2014 Pharm Dev Technol pmid:23590449
Pavićević ID et al. Fatty acids binding to human serum albumin: Changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal. 2014 Chem. Biol. Interact. pmid:25451573
Chen FY et al. TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. 2014 Int J Nanomedicine pmid:25298734
Díaz R et al. Identification of fatty acids in canine seminal plasma. 2014 Andrologia pmid:23398451
Sertoglu E et al. Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. 2014 Chem. Phys. Lipids pmid:24384240
Khodadoust S et al. Identification and determination of the fatty acid composition of Quercus brantii growing in southwestern Iran by GC-MS. 2014 Nat. Prod. Res. pmid:24499169
Wu MH et al. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. 2014 Sci Rep pmid:24651079
Kumar SS et al. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. 2014 Biochim. Biophys. Acta pmid:24440669
Wang J et al. A soybean acyl carrier protein, GmACP, is important for root nodule symbiosis. 2014 Mol. Plant Microbe Interact. pmid:24400939
Saerens L et al. Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion. 2014 Anal. Chim. Acta pmid:24331054