stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Ragnarsson G and Sjögren J Force-displacement measurements in tableting. 1985 J. Pharm. Pharmacol. pmid:2858558
Esezobo S The effect of some excipients on the physical properties of a paracetamol tablet formulation. 1985 J. Pharm. Pharmacol. pmid:2858567
Zoeller RA and Wood R The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. 1985 Biochim. Biophys. Acta pmid:2860925
Bangudu AB and Pilpel N Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. 1985 J. Pharm. Pharmacol. pmid:2862234
Yasuda H et al. Biphasic liberation of arachidonic and stearic acids during cerebral ischemia. 1985 J. Neurochem. pmid:2987409
Noy N and Zakim D Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase. 1985 Biochemistry pmid:2931113
Enk L et al. High-dose depot-medroxyprogesterone acetate--effects on the fatty acid composition of serum lecithin and cholesterol ester. 1985 Gynecol. Oncol. pmid:2933308
Onoda T et al. Antitumor activity of D-mannosamine in vitro: cytotoxic effect produced by mannosamine in combination with free fatty acids on human leukemia T-cell lines. 1985 Jpn. J. Clin. Oncol. pmid:3877190
Shanson DC et al. Erythromycin stearate, 1.5 g, for the oral prophylaxis of streptococcal bacteraemia in patients undergoing dental extraction: efficacy and tolerance. 1985 J. Antimicrob. Chemother. pmid:3882657
Boiron F et al. A comparison of substrate-dependent fatty acyl-CoA synthetase activities and ATP hydrolysis in membrane pellets from normal and trembler mouse sciatic nerves. 1985 Neurochem. Int. pmid:20492990
Wood CB et al. Increase of oleic acid in erythrocytes associated with malignancies. 1985 Br Med J (Clin Res Ed) pmid:3926106
George M and Chepenik KP Phospholipase A activities in embryonic palate mesenchyme cells in vitro. 1985 Biochim. Biophys. Acta pmid:3927980
Galey CI et al. Modulation of phospholipid metabolism in murine keratinocytes by tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. 1985 J. Invest. Dermatol. pmid:3930615
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Roughan PG Phosphatidylglycerol and chilling sensitivity in plants. 1985 Plant Physiol. pmid:16664127
Kaplan E and Ansari K High-performance liquid chromatography as a tool for identification of linolenic acid hydroperoxide prepared with soybean lipoxygenase. 1985 J. Chromatogr. pmid:3937844
Maiti H and Haye KR Does detection of chlamydial antibodies by microimmunofluorescence help in managing chlamydial lower genital tract infection in women? 1985 Genitourin Med pmid:3891584
Walker KA and Harwood JL Localization of chloroplastic fatty acid synthesis de novo in the stroma. 1985 Biochem. J. pmid:3994672
Jones PJ et al. Absorption of 13C-labeled stearic, oleic, and linoleic acids in humans: application to breath tests. 1985 J. Lab. Clin. Med. pmid:3998617
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Wadström T et al. Hydrophobized wound dressing in the treatment of experimental Staphylococcus aureus infections in the young pig. 1985 Acta Pathol Microbiol Immunol Scand B pmid:2417448
Wood CB et al. Reduction in the stearic to oleic acid ratio in the circulating red blood cells: a possible tumour marker in solid human neoplasms. 1985 Eur J Surg Oncol pmid:4007173
Harrison GA et al. Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis. 1985 J. Antimicrob. Chemother. pmid:4008379
Schreiner A and Digranes A Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. 1984 Sep-Oct Infection pmid:6511088
Blackett PR et al. Hyperlipidemia in acute lymphoblastic leukemia. 1984 Mar-Apr Ann. Clin. Lab. Sci. pmid:6585175
Hanna GM Nuclear magnetic resonance spectroscopic determination of dicyclomine hydrochloride in tablet, capsule, and injection dosage forms. 1984 Mar-Apr J Assoc Off Anal Chem pmid:6725188
Holub BJ and Celi B Evaluation of the fatty acid selectivity of a phosphatidylinositol-specific cytosolic phospholipase C from pig and human platelets. 1984 Feb-Mar Can. J. Biochem. Cell Biol. pmid:6518412
Ras GJ et al. Chemoprophylaxis with erythromycin stearate or amoxycillin in patients with chronic bronchitis--effects on cellular and humoral immune functions. 1984 Dec 22-29 S. Afr. Med. J. pmid:6515508
Anderson R et al. Studies on the effects of ingestion of a single 500 mg oral dose of erythromycin stearate on leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. 1984 J. Antimicrob. Chemother. pmid:6592163
Colombo I and Carli F Comparative evaluation of structure and micromeritics properties of magnesium stearate. 1984 Farmaco Prat pmid:6510514
Romanowski B and Grace M Non-gonococcal urethritis: a comparison of therapy with minicycline, tetracycline and erthromycin. 1984 Can Fam Physician pmid:21278971
Pediconi MF and Rodríguez de Turco EB Free fatty acid content and release kinetics as manifestations of cerebral lateralization in mouse brain. 1984 J. Neurochem. pmid:6726237
Kido H et al. Inhibition of chymase activity by long chain fatty acids. 1984 Arch. Biochem. Biophys. pmid:6424574
Feix JB et al. An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. 1984 Biochemistry pmid:6329270
Abumrad NA et al. Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. 1984 J. Biol. Chem. pmid:6746632
Wirthensohn G et al. Phospholipid metabolism in rat kidney cortical tubules. I. Effect of renal substrates. 1984 Biochim. Biophys. Acta pmid:6477951
Shechter Y and Henis YI Cis-unsaturated fatty acids induce both lipogenesis and calcium binding in adipocytes. 1984 Biochim. Biophys. Acta pmid:6477975
Bogdanov AA et al. Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes. 1984 FEBS Lett. pmid:6479332
Junginger HE Colloidal structures of O/W creams. 1984 Pharm Weekbl Sci pmid:6483570
Mogelson S and Lange LG Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. 1984 Biochemistry pmid:6487591
Boakes AJ et al. Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin. 1984 Br J Vener Dis pmid:6487986
Fernandes AC et al. Enhancement of human polymorphonuclear leucocyte motility by erythromycin in vitro and in vivo. 1984 S. Afr. Med. J. pmid:6463793
Yoshida S and Takeshita M Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. 1984 Biochim. Biophys. Acta pmid:6466693
Waldman SA et al. Acyl composition and phospholipase activities in plasma membranes isolated from rat embryos. 1984 Int. J. Biochem. pmid:6468725
Slevin ML et al. The pharmacokinetics of subcutaneous bolus cytosine arabinoside in an arachis oil plus aluminium distearate suspension. 1984 Invest New Drugs pmid:6511233
Vandermeerschen-Doizé F and Paquay R Effects of continuous long-term intravenous infusion of long-chain fatty acids on feeding behaviour and blood components of adult sheep. 1984 Appetite pmid:6517567
Hunter JM and Sommerville RG Erythromycin stearate in treating chlamydial infection of the cervix. 1984 Br J Vener Dis pmid:6518350
Farkas T Adaptation of fatty acid composition to temperature--a study on carp (Cyprinus carpio L.) liver slices. 1984 Comp. Biochem. Physiol., B pmid:6518757
Magill A and Becker AR Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate. 1984 J Pharm Sci pmid:6520780
Ueda A et al. Experimental study on the pathological changes in lung tissue caused by zinc stearate dust. 1984 Ind Health pmid:6526700