stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Tsuda K et al. Role of insulin in the regulation of membrane fluidity of erythrocytes in essential hypertension: an electron paramagnetic resonance investigation. 2000 Am. J. Hypertens. pmid:10821339
Coyle P et al. Severe lead poisoning in the plastics industry: a report of three cases. 2005 Am. J. Ind. Med. pmid:15662640
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
WILSON LW et al. THE HEMODYNAMIC EFFECTS OF INFUSIONS OF LONG CHAIN SATURATED FATTY ACIDS INTO DOGS. 1965 Am. J. Med. Sci. pmid:14254833
Doran TA et al. Amniotic fluid lecithin/sphingomyelin ratio, palmitic acid, palmitic acid/stearic acid ratio, total cortisol, creatinine, and percentage of lipid-positive cells in assessment of fetal maturity and fetal pulmonary maturity: a comparison. 1979 Am. J. Obstet. Gynecol. pmid:433991
Zackler J et al. A mass screening program for the detection of gonorrhea. 1972 Am. J. Obstet. Gynecol. pmid:4623083
Quinn PA et al. Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasmas. 1983 Am. J. Obstet. Gynecol. pmid:6849358
COX AJ and DEEDS F Dietary production of lipogranuloma in rats. 1958 Mar-Apr Am. J. Pathol. pmid:13520907
Qian MW and Eaton JW Iron translocation by free fatty acids. 1991 Am. J. Pathol. pmid:1750512
Wieland SJ et al. Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids. 1992 Am. J. Physiol. pmid:1514578
TROUT DL and ESTES EH Factors affecting liver uptake of serum free stearic acid-1-C14. 1962 Am. J. Physiol. pmid:13994303
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
Steffen DG and Platner WS Subcellular membrane fatty acids of rat heart after cold acclimation or thyroxine. 1976 Am. J. Physiol. pmid:961919
Michiels C et al. Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. 1993 Am. J. Physiol. pmid:8476019
Wang H et al. Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. 1997 Am. J. Physiol. pmid:9176199
LIN TM et al. Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. 1960 Am. J. Physiol. pmid:14417022
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Zoukhri D and Dartt DA Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. 1995 Am. J. Physiol. pmid:7900776
Oe H et al. Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. 1994 Am. J. Physiol. pmid:7943384
Kennett FF et al. Inhibition of myocardial rotenone-insensitive NADH cytochrome c reductase by amphiphilic compounds. 1984 Am. J. Physiol. pmid:6507637