| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bleyl DW and Przybilski H | [Diaplacental transition of selected fatty acids in the rat]. | 1991 | Nahrung | pmid:1865884 |
| Brestkina MD et al. | [Use of bio-testing on aquatic animals in the assessment of the quality of raw materials in the production of polymeric materials of medical purpose]. | 1991 | Gig Sanit | pmid:2055528 |
| Hart CM et al. | Supplemental fatty acids alter lipid peroxidation and oxidant injury in endothelial cells. | 1991 | Am. J. Physiol. | pmid:2058691 |
| Applegate KR and Glomset JA | Effect of acyl chain unsaturation on the conformation of model diacylglycerols: a computer modeling study. | 1991 | J. Lipid Res. | pmid:1797944 |
| Buttke TM et al. | Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1799970 |
| Denke MA and Grundy SM | Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. | 1991 | Am. J. Clin. Nutr. | pmid:1845606 |
| Morgan H et al. | Proton transport at the monolayer-water interface. | 1991 | Biochim. Biophys. Acta | pmid:1848448 |
| YashRoy RC | Protein heat denaturation and study of membrane lipid-protein interactions by spin label ESR. | 1991 | J. Biochem. Biophys. Methods | pmid:1848569 |
| Qian MW and Eaton JW | Iron translocation by free fatty acids. | 1991 | Am. J. Pathol. | pmid:1750512 |
| Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
| Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
| Squier TC et al. | Resolution of phospholipid conformational heterogeneity in model membranes by spin-label EPR and frequency-domain fluorescence spectroscopy. | 1991 | Biophys. J. | pmid:1646658 |
| Streichman S et al. | EPR study of the hydrophobic interaction of spectrin with fatty acids. | 1991 | Biochim. Biophys. Acta | pmid:1648396 |
| Irita K et al. | Substitution by fatty acids for phosphatidylserine in a reconstitution of phorbol ester binding to protein kinase C. | 1991 | Int. J. Biochem. | pmid:1650723 |
| Townsend WE et al. | Effect of level of endophyte infection, nitrogen fertilization rate, grazing period, and paddock exchange on some chemical properties of four bovine tissues. | 1991 | J. Anim. Sci. | pmid:1653201 |
| Koike R et al. | Physiological significance of fatty acid elongation system in adrenoleukodystrophy. | 1991 | J. Neurol. Sci. | pmid:1880537 |
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| Bogataj M et al. | Eudragit E microspheres containing bacampicillin: preparation by solvent removal methods. | 1991 Jul-Sep | J Microencapsul | pmid:1941447 |
| Smith DM and Waite M | Phosphatidylinositol hydrolysis by phospholipase A2 and C activities in human peripheral blood neutrophils. | 1992 | J. Leukoc. Biol. | pmid:1464738 |
| Ashes JR et al. | Incorporation of n-3 fatty acids of fish oil into tissue and serum lipids of ruminants. | 1992 | Lipids | pmid:1406074 |
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| Emken EA | What is the metabolic fate of dietary long-chain fatty acids (especially stearic acid) in normal physiological states, and how might this relate to thrombosis? | 1992 | Am. J. Clin. Nutr. | pmid:1414985 |
| Leinonen UI et al. | Physical and lubrication properties of magnesium stearate. | 1992 | J Pharm Sci | pmid:1491339 |
| Giusto NM et al. | Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system. | 1992 | Lipids | pmid:1491598 |
| Dotson KD et al. | High-performance liquid chromatography of human milk triacylglycerols and gas chromatography of component fatty acids. | 1992 | Lipids | pmid:1491614 |
| Judd AM and MacLeod RM | Thyrotropin-releasing hormone and lysine-bradykinin stimulate arachidonate liberation from rat anterior pituitary cells through different mechanisms. | 1992 | Endocrinology | pmid:1505463 |
| Johnson PE et al. | Effects of stearic acid and beef tallow on iron utilization by the rat. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1508937 |
| Wheelan P and Clay KL | Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. | 1992 | Biochim. Biophys. Acta | pmid:1511005 |
| Flynn TT et al. | Modification of plasma and hepatic lipids of guinea pigs by feeding high oleic acid pork compared with regular pork. | 1992 | J. Nutr. | pmid:1512635 |
| Wieland SJ et al. | Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids. | 1992 | Am. J. Physiol. | pmid:1514578 |
| NakonechnyÄ II et al. | [The atomic absorption determination of calcium, zinc, barium, lead and silver stearates in the air of a work area]. | 1992 | Gig Sanit | pmid:1427217 |
| Mensink RP et al. | Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. | 1992 | J. Lipid Res. | pmid:1431574 |
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| Dennis M and Kolattukudy PE | A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1608940 |
| el-Naghy MA et al. | Fungistatic action of natural oils and fatty acids on dermatophytic and saprophytic fungi. | 1992 | Zentralbl. Mikrobiol. | pmid:1609554 |
| Mitra A et al. | Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. | 1992 | Toxicol. Lett. | pmid:1595087 |
| Garcia Marquez MA et al. | [The effect of two lubricants (magnesium stearate and pruv) in the formation of tablets of four anti-ulcer agents/ by means of direct compression]. | 1992 | Pharm Acta Helv | pmid:1631172 |
| Bonanome A et al. | Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. | 1992 | Atherosclerosis | pmid:1632865 |
| Komata Y et al. | In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. | 1992 | J Pharm Sci | pmid:1403716 |
| Urquhart R et al. | omega-6 and omega-3 fatty acids: monolayer packing and effects on bilayer permeability and cholesterol exchange. | 1992 | Biochem. Int. | pmid:1535197 |
| Lagrost L | Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. | 1992 | Biochim. Biophys. Acta | pmid:1543738 |
| Rafi MA et al. | Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency. | 1992 | Am. J. Hum. Genet. | pmid:1350885 |
| Simões AP et al. | Incorporation of free fatty acids can explain alterations in the molecular species composition of phosphatidylcholine and phosphatidylethanolamine in human erythrocytes as induced by Plasmodium falciparum. | 1992 | Cell Biol. Int. Rep. | pmid:1327542 |
| Fanjul LF et al. | Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1329745 |