stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Boutonneuse Fever D001907 5 associated lipids
Foreign Bodies D005547 5 associated lipids
Prostatic Diseases D011469 4 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Chancroid D002602 4 associated lipids
Yaws D015001 4 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Syphilis, Latent D013592 4 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Calculi D002137 3 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
Wahle KW and Garton GA Desaturation of stearate by sheep tissue microsomal preparations. 1972 Biochem. J. pmid:4643297
Dudley DT and Spector AA Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. 1986 Biochem. J. pmid:3098231
COOKE NJ et al. The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). 1956 Biochem. J. pmid:13363830
DAWSON RM The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. 1958 Biochem. J. pmid:13522653
Bruce JS and Salter AM Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes. 1996 Biochem. J. pmid:8670161
Hasegawa K et al. Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH. 2008 Biochem. J. pmid:18637792
Yamamoto A and Kawashima Y Perfluorodecanoic acid enhances the formation of oleic acid in rat liver. 1997 Biochem. J. pmid:9230124
Weaire PJ and Kekwick RG The fractionation of the fatty acid synthetase activities of avocado mesocarp plastids. 1975 Biochem. J. pmid:1156381
Zhao H and Hardy RW Long-chain saturated fatty acids induce annexin II translocation to detergent-resistant membranes. 2004 Biochem. J. pmid:15099193
Veit M et al. Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. 1996 Biochem. J. pmid:8761467
Agarwal HC and Nair AM Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). 1976 Biochem. J. pmid:962852
Anderton P et al. Measles-virus-persistent infection in BGM cells. Modification of the incorporation of [3H]arachidonic acid and [14C]stearic acid into lipids. 1983 Biochem. J. pmid:6414459
Kemp P and Lander DJ The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. 1983 Biochem. J. pmid:6318740
Trinchera M et al. Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts. 1988 Biochem. J. pmid:3415659
Graham A et al. Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes. 1988 Biochem. J. pmid:3355493
Russell NJ and Harwood JL Changes in the acyl lipid composition of photosynthetic bacteria grown under photosynthetic and non-photosynthetic conditions. 1979 Biochem. J. pmid:115463
Price CJ and Rowe CE Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine. 1972 Biochem. J. pmid:5075269
Faas FH and Carter WJ Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism. 1982 Biochem. J. pmid:7181859
DUNCOMBE WG and GLASCOCK RF The contribution of dietary stearic acid to milk fat. 1954 Biochem. J. pmid:13172205
BERGSTROM S et al. Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. 1954 Biochem. J. pmid:13230010
Jordan BR and Harwood JL Fatty acid elongation by a particulate fraction from germinating pea. 1980 Biochem. J. pmid:7283974
NOBLE RC and MOORE JH FURTHER STUDIES ON THE LIPID METABOLISM OF THE NORMAL AND VITAMIN B-12 DEFICIENT CHICK EMBRYO. 1965 Biochem. J. pmid:14333549
SRIDHARA S and BHAT JV FURTHER INVESTIGATIONS OF THE INCORPORATION OF (1-14C)ACETATE INTO THE LIPIDS OF THE SILKWORM BOMBYX MORI L. 1965 Biochem. J. pmid:14340061
GLASCOCK RF and REINIUS LR Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. 1954 Biochem. J. pmid:13230049
ROOTS BI and JOHNSTON PV LIPIDS OF ISOLATED NEURONS. 1965 Biochem. J. pmid:14342249
Griffiths G et al. The acylation of sn-glycerol 3-phosphate and the metabolism of phosphatidate in microsomal preparations from the developing cotyledons of safflower (Carthamus tinctorius L.) seed. 1985 Biochem. J. pmid:4052051
McIlhinney RA and McGlone K Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. 1990 Biochem. J. pmid:2244873
Giudici TA et al. Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. 1986 Biochem. Med. Metab. Biol. pmid:2872907
Lurie E et al. N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. 1993 Biochem. Mol. Biol. Int. pmid:8358340
Melik-Nubarov NS et al. Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. 1993 Biochem. Mol. Biol. Int. pmid:8508145
Ohyama H et al. Age-related differences in synaptosomal membrane fluidity. 1995 Biochem. Mol. Biol. Int. pmid:8653075
Croxtall JD et al. Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. 1994 Biochem. Pharmacol. pmid:8304964
Erman A et al. Phospholipase A2 inhibitors. Differential inhibition of fatty acid acylation into kidney lipids by mepacrine and p-bromophenacyl bromide. 1983 Biochem. Pharmacol. pmid:6870935
Ondrias K et al. Spin label study of the perturbation effect of the local anaesthetics tetracaine and dibucaine on synaptosomes at pharmacological concentrations. 1987 Biochem. Pharmacol. pmid:2825709
Risé P et al. Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines. 2005 Biochem. Pharmacol. pmid:15763545
Hara A et al. Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. 2017 Biochem. Pharmacol. pmid:28450226
Rendu F et al. Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. 1989 Biochem. Pharmacol. pmid:2539823
Kerr BD et al. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. 2009 Biochem. Pharmacol. pmid:19523458
Bruce JS et al. Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes. 1995 Biochem. Soc. Trans. pmid:7672331
Sherrington EJ et al. Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. 1996 Biochem. Soc. Trans. pmid:8736816
Kaushik N and Vir S Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. 2000 Biochem. Soc. Trans. pmid:11171243
Parveez GK et al. Transgenic oil palm: production and projection. 2000 Biochem. Soc. Trans. pmid:11171275
Clouet P et al. Mitochondrial respiration on rumenic and linoleic acids. 2001 Biochem. Soc. Trans. pmid:11356175
Liu Q et al. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. 2000 Biochem. Soc. Trans. pmid:11288706
Wu F and Gaffney BJ Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. 2006 Biochemistry pmid:17029406
Huang G et al. Identification of the thiol ester linked lipids in apolipoprotein B. 1988 Biochemistry pmid:3365394
Perkins RC et al. Equilibrium binding of spin-labeled fatty acids to bovine serum albumin: suitability as surrogate ligands for natural fatty acids. 1982 Biochemistry pmid:6289869
Zornetzer GA et al. Solution structures of spinach acyl carrier protein with decanoate and stearate. 2006 Biochemistry pmid:16618110