stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Dong X et al. [Analysis of meibum by gas chromatography-mass spectrometry]. 2015 Zhonghua Yan Ke Za Zhi pmid:26693651
Chen Y et al. [Studies on chemical constituents of Forsythia suspensa (Thunb) Vahl]. 1999 Zhongguo Zhong Yao Za Zhi pmid:12205888
Liu Z et al. [Chemical constituents from root bark of Tripterygium hypoglaucum]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22256754
Tang HF et al. [Studies on the chemical constituents from marine brown alga Ishige okamurai (3)]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12774370
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--saponification reaction and saponification value]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15806965
Xiong W et al. [Hydrothobic constituents of Nyssa sinensis Oliv]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8737471
Shu R et al. [Chemical constituents of Cyclocarya paliurus (Batal.) Iljinsk]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8737472
Cao C et al. [Chemical study on petroleum ether portion of Sarcandra hainanensis]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19639789
Gu W et al. [Chemical composition of Fordia cauliflora Hemsl]. 1999 Zhongguo Zhong Yao Za Zhi pmid:12242814
Zhao XY et al. [Studies on chemical constituents from rhizome of Impatiens pritzellii var. hupehensis]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011279
Hu SY et al. [Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23311152
Wei S et al. [Chemical constituents in the stem of Premna crassa Hand. -Mazz]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2093323
Liang P et al. [Chemical constituents of Pericampylus glaucus (Lam.) Merr]. 1998 Zhongguo Zhong Yao Za Zhi pmid:11243154
Jian WX et al. [Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern]. 2010 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20815270
Zhang JW et al. [Studies on the chemical constituents of Toricellia angulata var. intermedia]. 2010 Zhong Yao Cai pmid:21434432
Chen M et al. [Study on the chemical constituents from Fructus Toosendan (III)]. 2011 Zhong Yao Cai pmid:22500422
Pi K et al. [Study on liposoluble constituents of Teucrium labiosum]. 2008 Zhong Yao Cai pmid:18973016
Yin AW and Huang SJ [Research on chemical constituents of xuefu zhuyu decoction]. 2011 Zhong Yao Cai pmid:22372145
Zeng XJ et al. [Chemical constituents of Berchemia lineate]. 2012 Zhong Yao Cai pmid:22822666
Duan J et al. [Analysis of ethereal extracts from Odondotermes formosanus and fungus garden]. 1999 Zhong Yao Cai pmid:12571918
Sun X et al. [Studies on chemical constituents of fat oil of Polygala tenuifolia]. 2000 Zhong Yao Cai pmid:12575116
Lian Z et al. [Studies on chemical constituents of Choerospondias axillaris]. 2003 Zhong Yao Cai pmid:12858769
Wang YN et al. [Study on chemical constituents from Anoectochilus chapaensis]. 2012 Zhong Yao Cai pmid:23236826
Zhu SH et al. [Study on the chemical constituents of Dichrocephala integrifolia]. 2010 Zhong Yao Cai pmid:20518304
Luan L et al. [Studies on the chemical constituents of extract with water from Forsythia suspensa]. 2010 Zhong Yao Cai pmid:20575415
Wang YY et al. [Studies on the chemical constituents of Sarcopyramis nepalensis]. 2009 Zhong Yao Cai pmid:20034215
Cai JY et al. [Studies on chemical constituents from Anoectochilus roxburghii]. 2008 Zhong Yao Cai pmid:18619237
Li YW et al. [Studies on the chemical constituents of Ficus microcarpa]. 2010 Zhong Yao Cai pmid:21049616
Ma BJ et al. [Chemical constituents study on the fruiting bodies of Lactarius rufus]. 2008 Zhong Yao Cai pmid:18619269
Wang Y et al. [Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia]. 2011 Zhong Xi Yi Jie He Xue Bao pmid:21288451
Zakhariv OIa and Ianovich VG [The utilization of [9,10-(3)H] stearic and [1-(14)C] linolenic acids in the in-vitro synthesis of lipids in ruminant tissues]. 1995 Jul-Aug Zh. Evol. Biokhim. Fiziol. pmid:8779280
el-Naghy MA et al. Fungistatic action of natural oils and fatty acids on dermatophytic and saprophytic fungi. 1992 Zentralbl. Mikrobiol. pmid:1609554
Kankofer M et al. The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. 1996 Zentralbl Veterinarmed A pmid:8940891
Kraus G et al. [The modification of different element levels in human blood by occupational cadmium exposure]. 1988 Zentralbl Bakteriol Mikrobiol Hyg B pmid:3138836
Shani J et al. Efficacy of sustained-release radioprotective drugs in vivo. 1987 Nov-Dec Z. Naturforsch., C, J. Biosci. pmid:2966504
Simpson JT et al. Identification of major lipids from the scent gland secretions of Dumeril's ground boa (Acrantophis dumerili Jan) by gas chromatography-mass spectrometry. 1988 Nov-Dec Z. Naturforsch., C, J. Biosci. pmid:3245880
Murkovic M et al. Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). 1996 Z Lebensm Unters Forsch pmid:8873459
Gonzalez-Castro MY et al. Effects of blanching, freezing and freeze-drying on the fatty acid contents of green beans. 1996 Z Lebensm Unters Forsch pmid:9123974
Schmidt P et al. [Animal experiments on barium stearate toxicity]. 1975 Z Gesamte Hyg pmid:1189478
Schmidt P et al. [Acute inhalation toxicity of cadmium stearate]. 1971 Z Gesamte Hyg pmid:5123074
Chung DJ et al. Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. 2007 Yonsei Med. J. pmid:17461529
Hatipoglu ON and Tasan Y A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. 2000 Yonsei Med. J. pmid:10957888
Chen JM et al. [Comparison of seed oil physicochemical characteristics among three cultivars of Jatropha curcas L]. 2009 Ying Yong Sheng Tai Xue Bao pmid:20353052
Bai YJ et al. [Structure identification of jujuboside E]. 2003 Yao Xue Xue Bao pmid:15040089
Chen DB et al. [In vitro and in vivo study of two kinds of long-circulating solid lipid nanoparticles containing paclitaxel]. 2002 Yao Xue Xue Bao pmid:12579901
Ye YQ et al. [Preparation and characterization of stearic acid-grafted chitosan oligosaccharide polymeric micelles]. 2004 Yao Xue Xue Bao pmid:15491108
Li CC et al. [In situ rat intestine absorption of paclitaxel-loaded solid lipid nanoparticles modified with cell-penetrating peptides]. 2013 Yao Xue Xue Bao pmid:23600154
Jiang RG et al. [Effect of surface modification on surface energy of lactose and performance of dry powder inhalations]. 2005 Yao Xue Xue Bao pmid:16011271
NAKAGAKI M and NISHINO M [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. III. COMPOSITION OF ALUMINUM STEARATE AND STRUCTURAL VISCOSITY OF BENZENE SOLUTION]. 1963 Yakugaku Zasshi pmid:14094211
NAKAGAKI M and NISHINO M [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. IV. EFFECT OF THERMAL TREATMENT ON THE STRUCTURE OF THE SOAP]. 1963 Yakugaku Zasshi pmid:14094212
Arai T and Hosoi Y [Determination of magnesium stearate in pharmaceutical preparations using derivatization with 2-nitrophenylhydrazine and HPLC]. 2005 Yakugaku Zasshi pmid:15738629
Sunagane N et al. [Possibility of interactions between prescription drugs and OTC drugs (2nd report)--interaction between levodopa preparation and OTC Kampo medicines for upset stomach]. 2006 Yakugaku Zasshi pmid:17077621
Goto S et al. [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. 1986 Yakugaku Zasshi pmid:3701600
Goto S et al. [Effect of magnesium stearate in preparation of eudragit RS-microcapsules containing drugs]. 1985 Yakugaku Zasshi pmid:3835255
Nakagawa H et al. [Effects of particle size of rifampicin and addition of magnesium stearate on release of rifampicin from hard gelatin capsules (author's transl)]. 1980 Yakugaku Zasshi pmid:7205556
Nadai M et al. [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. 1987 Yakugaku Zasshi pmid:3437396
NAKAGAKI M and NISHINO M [Studies on the physicochemical properties of aluminum soap. II. Structural viscosity of aluminum stearate in benzene]. 1963 Yakugaku Zasshi pmid:13937343
Iwao Y [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. 2015 Yakugaku Zasshi pmid:26423868
Miyake Y et al. [Studies on packing-property of pharmaceutical powders. 3. Influence of calcium stearate content on compacting phenomenon of pharmaceutical powders (author's transl)]. 1973 Yakugaku Zasshi pmid:4797567
Miyake Y et al. [Studies on packing-property of pharmaceutical powders. II. Compacting phenomenon of pharmaceutical powders in the course of mixing with calcium stearate]. 1972 Yakugaku Zasshi pmid:4675495
NISHINO M [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. V. STRUCTURAL VISCOSITY OF ALUMINUM STEARATES IN VEGETABLE OILS]. 1964 Yakugaku Zasshi pmid:14266543
NAKAGAKI M and NISHINO M [STUDIES ON THE PHYSICO-CHEMICAL PROPERTIES OF ALUMINUM SOAPS. VI. EFFECT OF ADDITIVES ON THE VISCOSITY OF BENZENE SOLUTION OF ALUMINUM DISTEARATE]. 1964 Yakugaku Zasshi pmid:14266544
KAKEMI K et al. [STUDIES ON SUCROSE ESTERS. 3. EFFECT OF SUCROSE ESTERS ON THE ABSORPTION OF DRUGS FROM THE ALIMENTARY TRACT]. 1964 Yakugaku Zasshi pmid:14266554
Kitajima J et al. [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. 1989 Yakugaku Zasshi pmid:2760813
El Semary NA The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. 2012 World J. Microbiol. Biotechnol. pmid:22806854
Chen JL et al. Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. 2010 World J. Gastroenterol. pmid:21155010
Liu Z et al. Changes in the electron paramagnetic resonance spectra of albumin-associated spin-labeled stearic acid as a diagnostic parameter of colorectal cancer. 2013 World J Surg Oncol pmid:24025321
Miranda LA et al. Performance of UASB and DAEB reactors in the anaerobic digestion of synthetic wastewater containing sodium oleate and sodium stereate. 2006 Water Sci. Technol. pmid:16939093
Alves MM et al. Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability. 2001 Water Res. pmid:11257881
Lalman JA and Bagley DM Anaerobic degradation and methanogenic inhibitory effects of oleic and stearic acids. 2001 Water Res. pmid:11471698
Kosukhin AB et al. [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. 1989 Mar-Apr Vopr. Med. Khim. pmid:2741412
Zaridze DG et al. [Fatty acid composition of phospholipids of erythrocyte membranes and risk of breast cancer]. 1990 Vopr Onkol pmid:2126901
Bridges CD et al. Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids. 1984 Vision Res. pmid:6543481
MacDonald RC et al. Inhibition of sendai virus-induced hemolysis by long chain fatty acids. 1984 Virology pmid:6324464
Nozawa CM and Apostolov K Increase in the saturation of C18 fatty acids induced by coxsackie B6 virus in Vero cells. 1982 Virology pmid:6285601
Kordyukova LV et al. Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. 2010 Virology pmid:20006369
Lavergne SN et al. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. 2016 Vet. Dermatol. pmid:26748887
Veit M and Siche S S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? 2015 Vaccine pmid:26387429
Colmano G et al. Activated silver coatings for surgical implants. 1979 Va Med pmid:316624
Yim B et al. Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. 2002 Ultrason Sonochem pmid:12219583
Mizukoshi Y et al. Preparation of platinum nanoparticles by sonochemical reduction of the Pt(IV) ions: role of surfactants. 2001 Ultrason Sonochem pmid:11105315
Walzthöny D et al. Ice crystals specifically decorate hydrophilic sites on freeze-fractured models membranes. 1981 Ultramicroscopy pmid:7281365
Nielsen GD et al. [Aspiration of talcum or powder containing zinc stearate by children]. 1979 Ugeskr. Laeg. pmid:442270
Williams KJ et al. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. 2011 Tuberculosis (Edinb) pmid:21764638
Cutler RR et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. 1987 Tubercle pmid:3448797
NadtochiÄ­ VV and BrodskiÄ­ RA [Absorption study of 3H-stearic acid in the rat small intestine using electron microscopic autoradiography]. 1982 Tsitologiia pmid:7135486
Meng W et al. A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. 2009 Trials pmid:19419555
Santos GM et al. Negative regulation by nuclear receptors: a plethora of mechanisms. 2011 Trends Endocrinol. Metab. pmid:21196123
HJORTH N and TROLLE-LASSEN C SKIN REACTIONS TO OINTMENT BASES. 1963 Trans St Johns Hosp Dermatol Soc pmid:14116129
Wenzel DG and Kleoppel JW Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. 1980 Toxicology pmid:7210021
Søndergaard D et al. Magnesium stearate given perorally to rats. A short term study. 1980 Toxicology pmid:7434368
Nohynek GJ et al. Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. 2006 Toxicol. Lett. pmid:16243460
Mitra A et al. Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. 1992 Toxicol. Lett. pmid:1595087
Salminen S and Salminen E Urinary excretion of orally administered oxalic acid in MYRJ 45-treated NMRI mice. 1987 Toxicol. Lett. pmid:3590233
FITZHUGH OG et al. Chronic oral toxicities of four stearic acid emulsifiers. 1959 Toxicol. Appl. Pharmacol. pmid:13659539
Michaut A et al. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. 2016 Toxicol. Appl. Pharmacol. pmid:26739624
Simon MN et al. Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. 2008 Toxicol In Vitro pmid:18395405
Yin L et al. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. 2016 Toxicol In Vitro pmid:26820058
Simon C et al. Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. 2016 Toxicol In Vitro pmid:27633901
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178