| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Infertility | D007246 | 3 associated lipids |
| Anemia, Dyserythropoietic, Congenital | D000742 | 2 associated lipids |
| Hypothalamic Diseases | D007027 | 3 associated lipids |
| Pneumoconiosis | D011009 | 3 associated lipids |
| Gallbladder Neoplasms | D005706 | 3 associated lipids |
| Legionnaires' Disease | D007877 | 4 associated lipids |
| Whooping Cough | D014917 | 6 associated lipids |
| Urethritis | D014526 | 9 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| GEYER RP et al. | Aerobic C14O2 formation from carboxyl-labeled stearic and palmitic acids in the presence of ascorbic acid. | 1955 | Arch. Biochem. Biophys. | pmid:14377605 |
| SULMAN FG | A note on the resorption and excretion of riboflavine from aluminium monostearate suspensions in the rat. | 1955 | J. Pharm. Pharmacol. | pmid:14392601 |
| POLYOXYETHYLENE stearates in food. | 1955 | Nutr. Rev. | pmid:14394517 | |
| SKOU JC | Local anaesthetics. V. The action of local anaesthetics on monomolecular layers of stearic acid. | 1954 | Acta Pharmacol Toxicol (Copenh) | pmid:14398295 |
| HURLEY HJ and SHELLEY WB | The colloidal state as a stimulus for non-allergic epithelioid granulomas: experimental studies in man with pure sodium stearate and palmitate. | 1959 | J. Invest. Dermatol. | pmid:14405513 |
| LIN TM et al. | Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. | 1960 | Am. J. Physiol. | pmid:14417022 |
| Naidu KA | Vitamin C in human health and disease is still a mystery? An overview. | 2003 | Nutr J | pmid:14498993 |
| Um SJ et al. | Potent cytotoxic effects of novel retinamide derivatives in ovarian cancer cells. | 2003 | Biol. Pharm. Bull. | pmid:14519946 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Watanabe L et al. | Initiating structural studies of Lys49-PLA2 homologues complexed with an anionic detergent, a fatty acid and a natural lipid. | 2003 | Protein Pept. Lett. | pmid:14561144 |
| Grassi M et al. | Theoretical and experimental study on theophylline release from stearic acid cylindrical delivery systems. | 2003 | J Control Release | pmid:14568409 |
| Sutch JC et al. | Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy. | 2003 | J Control Release | pmid:14568414 |
| Rao R and Lokesh BR | TG containing stearic acid, synthesized from coconut oil, exhibit lipidemic effects in rats similar to those of cocoa butter. | 2003 | Lipids | pmid:14584598 |
| Chavez JA and Summers SA | Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. | 2003 | Arch. Biochem. Biophys. | pmid:14592453 |
| Ohta K et al. | Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway. | 2003 | Brain Res. Mol. Brain Res. | pmid:14597232 |
| Hellgren L and Vincent J | Erythromycin stearate in acne vulgaris: its effect on the skin surface lipids and on the activity of purified pancreatic lipase. | 1978 | Dermatologica | pmid:145975 |
| Donoso M et al. | Prediction of tablet hardness and porosity using near-infrared diffuse reflectance spectroscopy as a nondestructive method. | 2003 | Pharm Dev Technol | pmid:14601960 |
| Bedair M and El Rassi Z | Capillary electrochromatography with monolithic stationary phases. II. Preparation of cationic stearyl-acrylate monoliths and their electrochromatographic characterization. | 2003 | J Chromatogr A | pmid:14604106 |
| Bedair M and El Rassi Z | Capillary electrochromatography with monolithic stationary phases. III. Evaluation of the electrochromatographic retention of neutral and charged solutes on cationic stearyl-acrylate monoliths and the separation of water-soluble proteins and membrane proteins. | 2003 | J Chromatogr A | pmid:14604107 |
| Mills E et al. | The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]. | 2003 | BMC Clin Pharmacol | pmid:14614780 |
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| Sakai N and Matile S | Anion-mediated transfer of polyarginine across liquid and bilayer membranes. | 2003 | J. Am. Chem. Soc. | pmid:14624583 |
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| Srinivas CR and Mukhi SV | Stethoscope earpiece-induced chemical depigmentation. | 2003 | Contact Derm. | pmid:14641368 |
| Capelle HA et al. | Sodium stearate adsorption onto titania pigment. | 2003 | J Colloid Interface Sci | pmid:14643230 |
| Bussemer T et al. | A pulsatile drug delivery system based on rupturable coated hard gelatin capsules. | 2003 | J Control Release | pmid:14644583 |
| Smith DM and Waite M | Phosphatidylinositol hydrolysis by phospholipase A2 and C activities in human peripheral blood neutrophils. | 1992 | J. Leukoc. Biol. | pmid:1464738 |
| Baer DJ et al. | Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets. | 2003 | J. Nutr. | pmid:14652360 |
| Liang X et al. | The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading. | 2004 | J. Biol. Chem. | pmid:14660555 |
| Droke EA et al. | Fatty acids alter monolayer integrity, paracellular transport, and iron uptake and transport in Caco-2 cells. | 2003 | Biol Trace Elem Res | pmid:14665727 |
| Hasaba A et al. | Stearic acid stimulates FA ethyl ester synthesis in HepG2 cells exposed to ethanol. | 2003 | Lipids | pmid:14669970 |
| Gu CH et al. | Importance of using physiologically relevant volume of dissolution medium to correlate the oral exposure of formulations of BMS-480188 mesylate. | 2004 | Int J Pharm | pmid:14698591 |
| Amar I et al. | Solubilization patterns of lutein and lutein esters in food grade nonionic microemulsions. | 2003 | J. Agric. Food Chem. | pmid:14705912 |
| Wang L et al. | Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | 2003 | Nutr Metab Cardiovasc Dis | pmid:14717057 |
| Yu BT et al. | Enhanced liver targeting by synthesis of N1-stearyl-5-Fu and incorporation into solid lipid nanoparticles. | 2003 | Arch. Pharm. Res. | pmid:14723346 |
| Inoue T et al. | Solid-liquid phase behavior of binary fatty acid mixtures. 1. Oleic acid/stearic acid and oleic acid/behenic acid mixtures. | 2004 | Chem. Phys. Lipids | pmid:14725997 |
| Swaminathan V and Kildsig DO | An examination of the moisture sorption characteristics of commercial magnesium stearate. | 2001 | AAPS PharmSciTech | pmid:14727865 |
| Yonezawa T et al. | Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741707 |
| Sattar SP et al. | Inert medication ingredients causing nonadherence due to religious beliefs. | 2004 | Ann Pharmacother | pmid:14766995 |
| Cunnane SC | Metabolism of polyunsaturated fatty acids and ketogenesis: an emerging connection. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14769482 |
| KOSS FH and LIEBSCHNER K | [Significance of alpha alpha-dimethylstearic acid in tuberculosis]. | 1950 | Klin. Wochenschr. | pmid:14804983 |
| ZABIN I | On the conversion of palmitic acid to stearic acid in animal tissues. | 1951 | J. Biol. Chem. | pmid:14832248 |
| KIVITS M | [Frambesia therapy with oil procaine-penicillin with aluminium stearate]. | 1951 | Ann Soc Belg Med Trop (1920) | pmid:14838448 |
| WEITZEL G and WOJAHN J | [Biochemistry of branched carboxylic acids. VII. Preparation of racemic monomethyl-stearic acids]. | 1951 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:14860764 |
| WEINMAN EO et al. | Conversion of first and sixth carbons of stearic acid to carbon dioxide by rats. | 1951 | J. Biol. Chem. | pmid:14861197 |
| Zhao CH et al. | Sex pheromone biosynthesis in the pine caterpillar moth, Dendrolimus punctatus (Lepidoptera: Lasiocampidae): pathways leading to Z5-monoene and 5,7-conjugated diene components. | 2004 | Insect Biochem. Mol. Biol. | pmid:14871622 |
| Leinonen UI et al. | Physical and lubrication properties of magnesium stearate. | 1992 | J Pharm Sci | pmid:1491339 |
| Giusto NM et al. | Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system. | 1992 | Lipids | pmid:1491598 |
| Dotson KD et al. | High-performance liquid chromatography of human milk triacylglycerols and gas chromatography of component fatty acids. | 1992 | Lipids | pmid:1491614 |
| Wang Y et al. | LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. | 2004 | J. Lipid Res. | pmid:14967823 |