stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Decsi T et al. Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. 2002 Lipids pmid:12530555
Murakami C et al. A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid. 2003 Biochim. Biophys. Acta pmid:12535613
Vink BW et al. A case of rhinolithiasis in botswana: a mineralogical, microscopic and chemical study. 2002 J Laryngol Otol pmid:12537618
Zhang Q et al. [Retention behavior of solutes on liquid chromatographic column packed with dynamically modified zirconia]. 1999 Se Pu pmid:12549113
Rege PR et al. Spray-dried chitinosans. Part II: in vitro drug release from tablets made from spray-dried chitinosans. 2003 Int J Pharm pmid:12550780
McDaid FM et al. Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug-excipient interactions. 2003 Int J Pharm pmid:12550799
Higashi N and Senoo H Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study. 2003 Anat Rec A Discov Mol Cell Evol Biol pmid:12552640
Heurtault B et al. The influence of lipid nanocapsule composition on their size distribution. 2003 Eur J Pharm Sci pmid:12554073
Fee JV et al. Influence of hydrophobic materials on dissolution of a nondisintegrating hydrophilic solid (potassium chloride). 1976 J Pharm Sci pmid:1255446
Alvarez-Lueje A et al. A selective HPLC method for determination of lercanidipine in tablets. 2003 J Pharm Biomed Anal pmid:12560043
Ulloth JE et al. Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells. 2003 J. Neurochem. pmid:12562510
Matera M et al. History of L-carnitine: implications for renal disease. 2003 J Ren Nutr pmid:12563618
Rastogi S et al. Effect of treatment for Chlamydia trachomatis during pregnancy. 2003 Int J Gynaecol Obstet pmid:12566185
Duan J et al. [Analysis of ethereal extracts from Odondotermes formosanus and fungus garden]. 1999 Zhong Yao Cai pmid:12571918
Sun X et al. [Studies on chemical constituents of fat oil of Polygala tenuifolia]. 2000 Zhong Yao Cai pmid:12575116
Begum S et al. Pentacyclic triterpenoids from the aerial parts of Lantana camara. 2003 Chem. Pharm. Bull. pmid:12576645
Chen DB et al. [In vitro and in vivo study of two kinds of long-circulating solid lipid nanoparticles containing paclitaxel]. 2002 Yao Xue Xue Bao pmid:12579901
Steinberg FM et al. Cocoa and chocolate flavonoids: implications for cardiovascular health. 2003 J Am Diet Assoc pmid:12589329
Tsydendambaev VD and Vereshchagin AG Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. 2003 J. Agric. Food Chem. pmid:12590468
Spencer MM et al. Mapping the Fas locus controlling stearic acid content in soybean. 2003 Theor. Appl. Genet. pmid:12595989
Lisetski LN et al. Effects of membranotropic agents on mono- and multilayer structures of dipalmitoylphosphatidylcholine. 2002 Eur. Biophys. J. pmid:12602341
Weigert C et al. Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase. 2003 Diabetes pmid:12606504
Adams ML and Kwon GS Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles: effects of acyl chain length. 2003 J Control Release pmid:12618020
Al-Belasy FA and Hairam AR The efficacy of azithromycin in the treatment of acute infraorbital space infection. 2003 J. Oral Maxillofac. Surg. pmid:12618970
Fernández-Moya V et al. Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. 2003 Planta pmid:12624771
Yamashita T et al. [Blood concentration and urinary excretion in human of OE-7, a gastric hard capsule containing enteric-coated granules. I (author's transl)]. 1976 Jpn J Antibiot pmid:1263346
Musiał W and Kubis A Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum. 2003 Eur J Pharm Biopharm pmid:12637103
Adlof RO and List GR Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. 2003 J. Agric. Food Chem. pmid:12643679
Grassi M et al. Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system. 2003 J Control Release pmid:12644364
Sabbah A [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. 1976 Nouv Presse Med pmid:1264643
Sugimoto T et al. Synthesis of uniform anatase TiO2 nanoparticles by gel-sol method. 4. Shape control. 2003 J Colloid Interface Sci pmid:12651133
Roy S et al. Characterization of physical mixtures and directly compressed tablets of sulfamerazine polymorphs: implications on in vitro release characteristics. 2003 J Pharm Sci pmid:12661061
Sanders TA et al. Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats. 2003 Am. J. Clin. Nutr. pmid:12663272
Heude B et al. Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study. 2003 Am. J. Clin. Nutr. pmid:12663275
Eitel K et al. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. 2003 Diabetes pmid:12663471
Guo M and Augsburger LL Potential application of silicified microcrystalline cellulose in direct-fill formulations for automatic capsule-filling machines. 2003 Pharm Dev Technol pmid:12665197
Lundberg B Thermal properties of systems containing cholesteryl esters and triglycerides. 1976 Acta Chem. Scand., B, Org. Chem. Biochem. pmid:1266525
Bolhuis GK et al. Hollow filler-binders as excipients for direct compaction. 2003 Pharm. Res. pmid:12669977
Pickart LR and Thaler MM Free fatty acids and albumin as mediators of thrombin-stimulated fibrinogen synthesis. 1976 Am. J. Physiol. pmid:1267031
Bonaventure G et al. Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth. 2003 Plant Cell pmid:12671095
Feller SE et al. Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. 2003 J. Am. Chem. Soc. pmid:12683809
Lu ZH et al. Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. 2003 Biochem. Biophys. Res. Commun. pmid:12684033
Ayvaz G et al. Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets. 2002 Diabetes Metab. pmid:12688627
Sauvant P et al. Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake. 2003 Metab. Clin. Exp. pmid:12701068
AbuGhazaleh AA et al. Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. 2003 J. Dairy Sci. pmid:12703631
Siswoyo TA and Morita N Thermal properties of partially hydrolyzed starch-glycerophosphatidylcholine complexes with various acyl chains. 2003 J. Agric. Food Chem. pmid:12720409
Eitel K et al. [Apoptosis induced by free fatty acids]. 2003 Med. Klin. (Munich) pmid:12721668
Mashek DG and Grummer RR Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. 2003 J. Dairy Sci. pmid:12741546
Adams ML et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules pmid:12741794
Gorinstein S et al. Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. 2003 J. Nutr. Biochem. pmid:12742543
Torres A et al. Characterization of surface n-alkanes and fatty acids of the epiphytic lichen Xanthoria parietina, its photobiont a green alga Trebouxia sp., and its mycobiont, from the Jerusalem hills. 2003 Eur. J. Biochem. pmid:12752431
Garzón Serra Mde L and Villafuerte Robles L Compactibility of agglomerated mixtures of calcium carbonate and microcrystalline cellulose. 2003 Int J Pharm pmid:12753762
Planinsek O and Buckton G Inverse gas chromatography: considerations about appropriate use for amorphous and crystalline powders. 2003 J Pharm Sci pmid:12761817
Lo YL Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. 2003 J Control Release pmid:12767705
Tang HF et al. [Studies on the chemical constituents from marine brown alga Ishige okamurai (3)]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12774370
Bulotta A et al. GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release. 2003 J. Lipid Res. pmid:12777469
Ogwal S and Xide TU Bioavailability and stability of erythromycin delayed release tablets. 2001 Afr Health Sci pmid:12789122
Wu PC et al. Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. 2003 Eur J Pharm Sci pmid:12791413
Tholstrup T et al. Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. 2003 Eur J Clin Nutr pmid:12792657
Brunengraber DZ et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12799315
del Carmen Ramírez-Medeles M et al. Amino acid sequence, biochemical characterization, and comparative modeling of a nonspecific lipid transfer protein from Amaranthus hypochondriacus. 2003 Arch. Biochem. Biophys. pmid:12801509
Wu PC et al. Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose. 2003 Int J Pharm pmid:12818816
Mittendorfer B et al. What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? 2003 Diabetes pmid:12829627
Yang L et al. Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. 2003 J. Biol. Chem. pmid:12829715
McNamara S et al. Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. 2003 Anim. Reprod. Sci. pmid:12853178
Lian Z et al. [Studies on chemical constituents of Choerospondias axillaris]. 2003 Zhong Yao Cai pmid:12858769
Mantipragada SB et al. Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. 2003 Biochemistry pmid:12885251
Duong NH et al. A homogeneity study using NIR spectroscopy: tracking magnesium stearate in Bohle bin-blender. 2003 Drug Dev Ind Pharm pmid:12889786
Ceschel GC et al. Degradation of components in drug formulations: a comparison between HPLC and DSC methods. 2003 J Pharm Biomed Anal pmid:12899995
Jin F et al. Oxidation reaction of high molecular weight carboxylic acids in supercritical water. 2003 Environ. Sci. Technol. pmid:12901673
Mashek DG and Grummer RR Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. 2003 J. Dairy Sci. pmid:12906057
Yassin AA et al. Effect of enzymatic interesterification on melting point of palm olein. 2003 Appl. Biochem. Biotechnol. pmid:12909731
Lyon RC et al. Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. 2002 AAPS PharmSciTech pmid:12916932
Swaminathan V and Kildsig DO Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. 2002 AAPS PharmSciTech pmid:12916934
Muzíková J and Horácek J [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. 2003 Ceska Slov Farm pmid:12924068
Ohta KM et al. Effect of geometric structure and surface wettability of glidant on tablet hardness. 2003 Int J Pharm pmid:12927389
Bracconi P et al. Structural properties of magnesium stearate pseudopolymorphs: effect of temperature. 2003 Int J Pharm pmid:12927393
El-Assaad W et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. 2003 Endocrinology pmid:12933690
Liu CL et al. [Effect of surface decoration on the spectral characteristics of alpha-Fe2O3 ultrafine particles]. 2003 Guang Pu Xue Yu Guang Pu Fen Xi pmid:12939995
Sirri F et al. Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. 2003 Poult. Sci. pmid:12943310
Dave PC et al. Calculating order parameter profiles utilizing magnetically aligned phospholipid bilayers for 2H solid-state NMR studies. 2003 Sep-Nov Solid State Nucl Magn Reson pmid:12943910
Sun Y et al. [The study of the microwave reaction of stearic acid and pentyl amine]. 2000 Guang Pu Xue Yu Guang Pu Fen Xi pmid:12945403
Zeng F et al. [Analysis on infrared spectrum of human body gallstone with comparative method]. 2001 Guang Pu Xue Yu Guang Pu Fen Xi pmid:12947655
Kajikawa M et al. MpFAE3, a beta-ketoacyl-CoA synthase gene in the liverwort Marchantia polymorpha L., is preferentially involved in elongation of palmitic acid to stearic acid. 2003 Biosci. Biotechnol. Biochem. pmid:12951498
Topping DL and Targ ME Time-course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. 1975 Horm. Res. pmid:130333
DOXIADIS SA Procaine penicillin with aluminium monostearate; infrequent injections for children. 1953 Lancet pmid:13085786
BUTCHER EO Penetration of radioactive stearic acid into the skin of the rat. 1953 J. Invest. Dermatol. pmid:13096866
Dwight JF et al. Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes. 1992 Clin. Sci. pmid:1310925
BERNHARD K and GLOOR U [Some other fatty acids with vitamin F effect]. 1953 Helv Physiol Pharmacol Acta pmid:13128629
MUNZEL K and AMMANN R [On the washable fat-in-water ointments. I. Description and characteristics of fat-in-water ointments]. 1953 Pharm Acta Helv pmid:13133659
Gault MH et al. Heparin, fatty acids and sodium, potassium-ATPase inhibition by plasma factors during hemodialysis. 1992 Nephron pmid:1314335
VALADE P and COSTE E [Toxicity of the organic lead salts; experimental study]. 1953 Arch Mal Prof pmid:13149301
MUNZEL K and AMMANN R [On washable fat-in-water ointments. IV. Stearate ointments]. 1954 Pharm Acta Helv pmid:13166515
DUNCOMBE WG and GLASCOCK RF The contribution of dietary stearic acid to milk fat. 1954 Biochem. J. pmid:13172205
SHAFER JK and SMITH CA Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. 1954 Bull. World Health Organ. pmid:13182589
MUNZEL K and AMMANN R [Washable oil-water ointments. V. Complex-emulsified ointments; differences between stearate- and complex-emulsified ointments]. 1954 Pharm Acta Helv pmid:13194353
SCRIBANTE P and FAVARGER P [Studies on digestibility of stearic acid and its glyceric esters in rat]. 1954 Helv Physiol Pharmacol Acta pmid:13201008
Boza J et al. Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. 1992 Jul-Aug JPEN J Parenter Enteral Nutr pmid:1322471
BERGSTROM S et al. Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. 1954 Biochem. J. pmid:13230010
GLASCOCK RF and REINIUS LR Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. 1954 Biochem. J. pmid:13230049