| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anemia, Dyserythropoietic, Congenital | D000742 | 2 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dohme F et al. | Digestive and metabolic utilization of lauric, myristic and stearic acid in cows, and associated effects on milk fat quality. | 2004 | Arch Anim Nutr | pmid:15195905 |
| NIGHTINGALE G et al. | Effect of dihydroxystearic acid on vitamin K synthesis by rats. | 1947 | Arch Biochem | pmid:20291026 |
| Sayari A and Gargouri Y | [Enzymatic synthesis of homogenous triacylglycerol in media without solvent]. | 2006 | Arch Inst Pasteur Tunis | pmid:19388599 |
| Bengochea LA et al. | Changes in microsomal phospholipid fatty acids composition in cholestatic rats. | 1992 Mar-Apr | Arch Int Physiol Biochim Biophys | pmid:1379485 |
| Nicoletti R et al. | [Palmitic acid-stearic acid ratio with reference to the fatty tissue properties in the human species]. | 1979 May-Jun | Arch Kriminol | pmid:573992 |
| Caille MP et al. | [Acute forms of lead poisoning by lead stearate]. | 1971 | Arch Mal Prof | pmid:5123552 |
| VALADE P and COSTE E | [Toxicity of the organic lead salts; experimental study]. | 1953 | Arch Mal Prof | pmid:13149301 |
| NORKIN SA et al. | EFFECT OF ALBUMIN AND FATTY ACIDS ON CELLULAR GROWTH IN VITRO. | 1965 | Arch Pathol | pmid:14322948 |
| Weston WL and Morelli JG | Steroid rosacea in prepubertal children. | 2000 | Arch Pediatr Adolesc Med | pmid:10632252 |
| BOUCROT P and CLEMENT J | [METABOLIC TRANSFORMATIONS SUSTAINED BY PALMITIC AND STEARIC ACIDS DURING THEIR DIGESTION AND ABSORPTION]. | 1965 | Arch Sci Physiol (Paris) | pmid:14348516 |
| Wagner K et al. | Influence of duodenal infusion of nicotinic acid on the milk fat composition of dairy cows. | 1997 | Arch Tierernahr | pmid:9272222 |
| Rizzuti B et al. | Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation. | 2015 | Arch. Biochem. Biophys. | pmid:26048999 |
| Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
| WALLEN LL et al. | The microbiological production of 10-hydroxystearic acid from oleic acid. | 1962 | Arch. Biochem. Biophys. | pmid:13998583 |
| Crost S et al. | Hormonal effects on mitochondrial respiration: potential role of endogenous lipolytic activities. | 1987 | Arch. Biochem. Biophys. | pmid:3113334 |
| LONG CL et al. | Studies on absorption and metabolism of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584006 |
| LONG CL et al. | An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584007 |
| Porra RJ and Stumpf PK | Lipid biosynthesis in developing and germinating soybean cotyledons. The formation of palmitate and stearate by chopped tissue and supernatant preparations. | 1976 | Arch. Biochem. Biophys. | pmid:987755 |
| Roughan PG et al. | Metabolism of exogenous long-chain fatty acids by spinach leaves. | 1987 | Arch. Biochem. Biophys. | pmid:3426240 |
| Smith DM and Waite M | Phospholipid metabolism in human neutrophil subfractions. | 1986 | Arch. Biochem. Biophys. | pmid:3083776 |
| Singh H and Poulos A | A comparative study of stearic and lignoceric acid oxidation by human skin fibroblasts. | 1986 | Arch. Biochem. Biophys. | pmid:3767370 |
| Oh-Hashi Y et al. | Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. | 1986 | Arch. Biochem. Biophys. | pmid:3729431 |
| Tonnet ML and Green AG | Characterization of the seed and leaf lipids of high and low linolenic acid flax genotypes. | 1987 | Arch. Biochem. Biophys. | pmid:3813554 |
| Kido H et al. | Inhibition of chymase activity by long chain fatty acids. | 1984 | Arch. Biochem. Biophys. | pmid:6424574 |
| del Carmen RamÃrez-Medeles M et al. | Amino acid sequence, biochemical characterization, and comparative modeling of a nonspecific lipid transfer protein from Amaranthus hypochondriacus. | 2003 | Arch. Biochem. Biophys. | pmid:12801509 |
| VAHOUNY GV et al. | MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. | 1964 | Arch. Biochem. Biophys. | pmid:14211570 |
| Nishihira J et al. | Identification of the hydrophobic ligand-binding region in recombinant glutathione S-transferase P and its binding effect on the conformational state of the enzyme. | 1993 | Arch. Biochem. Biophys. | pmid:8470890 |
| ROGENESS G and ABOOD LG | THE ACTION OF CALCIUM AND ANTICHOLINERGIC PSYCHOTOMIMETIC AGENTS ON SURFACE FILMS. | 1964 | Arch. Biochem. Biophys. | pmid:14217198 |
| Pajor L et al. | Microsomal desaturation of stearic acid in relation to lymphocyte activation. | 1986 | Arch. Biochem. Biophys. | pmid:3485399 |
| SKIPSKI VP et al. | Identification of 2-hydroxystearic acid in spinal cord phrenosine by chromatographic separation of hydroxy fatty acids. | 1959 | Arch. Biochem. Biophys. | pmid:13661981 |
| Sharma P et al. | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. | 2013 | Arch. Biochem. Biophys. | pmid:23149273 |
| SKIPSKI VP and MOREHOUSE MG | THE INCORPORATION OF INGESTED GLYCEROL-C14 INTO THE LIPIDS ON THE RAT. | 1964 | Arch. Biochem. Biophys. | pmid:14234504 |
| PORTMAN OW and SUGANO M | FACTORS INFLUENCING THE LEVEL AND FATTY ACID SPECIFICITY OF THE CHOLESTEROL ESTERIFICATION ACTIVITY IN HUMAN PLASMA. | 1964 | Arch. Biochem. Biophys. | pmid:14236639 |
| JACKSON HD et al. | FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. | 1964 | Arch. Biochem. Biophys. | pmid:14240563 |
| GEYER RP et al. | Aerobic C14O2 formation from carboxyl-labeled stearic and palmitic acids in the presence of ascorbic acid. | 1955 | Arch. Biochem. Biophys. | pmid:14377605 |
| Metz SA and Dunlop M | Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol. | 1990 | Arch. Biochem. Biophys. | pmid:2125821 |
| Nemecz G et al. | Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. | 1991 | Arch. Biochem. Biophys. | pmid:1897956 |
| Chavez JA and Summers SA | Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. | 2003 | Arch. Biochem. Biophys. | pmid:14592453 |
| Muñoz-Espin T et al. | Erythromycin versus tetracycline for treatment of Mediterranean spotted fever. | 1986 | Arch. Dis. Child. | pmid:3535687 |
| HUEPER WC and PAYNE WW | Polyoxyethylene(8)stearate. Carcinogenic studies. | 1963 | Arch. Environ. Health | pmid:13955486 |
| Eltahlawy H et al. | Evidence for two-step regulation of pheromone biosynthesis by the pheromone biosynthesis-activating neuropeptide in the moth Heliothis virescens. | 2007 | Arch. Insect Biochem. Physiol. | pmid:17294424 |
| Choi MY et al. | Pheromone biosynthetic pathways in the moths Heliothis subflexa and Heliothis virescens. | 2005 | Arch. Insect Biochem. Physiol. | pmid:15898118 |
| Sanders KL et al. | Relapse of Legionnaires' disease in a renal transplant recipient. | 1980 | Arch. Intern. Med. | pmid:6992727 |
| Abramov LA et al. | Acute respiratory distress caused by erythromycin hypersensitivity. | 1978 | Arch. Intern. Med. | pmid:666483 |
| Ibáñez L et al. | Population-based drug-induced agranulocytosis. | 2005 | Arch. Intern. Med. | pmid:15851637 |
| Menéndez R et al. | In vitro and in vivo study of octacosanol metabolism. | 2005 Mar-Apr | Arch. Med. Res. | pmid:15847942 |
| Cieśliński H et al. | A cold-adapted esterase from psychrotrophic Pseudoalteromas sp. strain 643A. | 2007 | Arch. Microbiol. | pmid:17516048 |
| Le Hénaff M and Fontenelle C | Chemical analysis of processing of spiralin, the major lipoprotein of Spiroplasma melliferum. | 2000 May-Jun | Arch. Microbiol. | pmid:10896212 |
| Garton NJ and Sutcliffe IC | Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis. | 2006 | Arch. Microbiol. | pmid:16320036 |
| Carranco E et al. | Carbamazepine toxicity induced by concurrent erythromycin therapy. | 1985 | Arch. Neurol. | pmid:3977647 |
| Slomiany BL et al. | Lipid composition of the matrix of human submandibular salivary gland stones. | 1982 | Arch. Oral Biol. | pmid:6958224 |
| Ahmad SN et al. | Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. | 1990 | Arch. Oral Biol. | pmid:2281999 |
| Mutalik S et al. | Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. | 2007 | Arch. Pharm. Res. | pmid:17366745 |
| Lee SH et al. | End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression. | 2012 | Arch. Pharm. Res. | pmid:23054717 |
| Kim IS and Oh IJ | Preparation and characterization of stearic acid-pullulan nanoparticles. | 2010 | Arch. Pharm. Res. | pmid:20512475 |
| Kasliwal N et al. | Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. | 2011 | Arch. Pharm. Res. | pmid:22076769 |
| Jeong SH and Park K | Simple preparation of coated resin complexes and their incorporation into fast-disintegrating tablets. | 2010 | Arch. Pharm. Res. | pmid:20191352 |
| Yu BT et al. | Enhanced liver targeting by synthesis of N1-stearyl-5-Fu and incorporation into solid lipid nanoparticles. | 2003 | Arch. Pharm. Res. | pmid:14723346 |
| Cha KH et al. | Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. | 2009 | Arch. Pharm. Res. | pmid:20091273 |
| Peura P et al. | The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. | 1986 | Arch. Toxicol. Suppl. | pmid:3468932 |
| Zhou X et al. | The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. | 2013 | Archaea | pmid:23710130 |
| MALJKOVIC I | [A CASE OF CHRONIC OCCUPATIONAL POISONING WITH LEAD STEARATE AND CARBONATE]. | 1964 | Arh Hig Rada Toksikol | pmid:14342211 |
| NadtochiÄ VV and BrodskiÄ RA | [Absorption routes of stearic acid and leucine in the small intestine of the rat after gamma irradiation]. | 1983 | Arkh Anat Gistol Embriol | pmid:6639383 |
| Mitropoulos KA et al. | Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. | 1994 | Arterioscler. Thromb. | pmid:8305411 |
| Anderson EK et al. | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22556332 |
| Turpeinen AM et al. | Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9484999 |
| Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
| Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
| Tulenko TN and Rabinowitz JL | Metabolism of C14 mevalonate by adult and fetal arteries. | 1983 | Artery | pmid:6677248 |
| Krzeski P et al. | Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. | 2007 | Arthritis Res. Ther. | pmid:17958901 |
| Chiang EP et al. | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. | 2005 | Arthritis Res. Ther. | pmid:16277693 |
| Kumar Gaur P et al. | Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. | 2016 | Artif Cells Nanomed Biotechnol | pmid:26375758 |
| Yan G et al. | Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25287740 |
| Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
| Chen Q et al. | Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. | 2015 | Artif Cells Nanomed Biotechnol | pmid:24093764 |
| Tükel S et al. | Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. | 2013 | Artif Cells Nanomed Biotechnol | pmid:23305558 |
| Wang W et al. | Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26754958 |
| Sastri MS et al. | In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. | 1993 | Arzneimittelforschung | pmid:8489559 |
| Männistö P et al. | Absorption of erythromycin. A cross-over study in healthy volunteers. | 1975 | Arzneimittelforschung | pmid:1106445 |
| Asgary S et al. | Evaluation of fatty acid content of some Iranian fast foods with emphasis on trans fatty acids. | 2009 | Asia Pac J Clin Nutr | pmid:19713177 |
| Cohn JS et al. | Reduction in intestinal cholesterol absorption by various food components: mechanisms and implications. | 2010 | Atheroscler Suppl | pmid:20439167 |
| Ebbesson SO et al. | Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. | 2008 | Atherosclerosis | pmid:18054937 |
| HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
| van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
| Berlin E et al. | Influence of saturated and unsaturated fats on platelet fatty acids in cholesterol-fed rabbits. | 1987 | Atherosclerosis | pmid:3827974 |
| Sanders TA et al. | Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). | 2000 | Atherosclerosis | pmid:10729392 |
| van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
| Bonanome A et al. | Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. | 1992 | Atherosclerosis | pmid:1632865 |
| Uehara Y et al. | Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. | 2007 | Atherosclerosis | pmid:16730733 |
| Spigoni V et al. | Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. | 2017 | Atherosclerosis | pmid:28892713 |
| Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
| Ishikado A et al. | Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. | 2009 | Atherosclerosis | pmid:19215923 |
| Cooksley WG and Powell LW | Erythromycin jaundice: diagnosis by an in vitro challenge test. | 1977 | Aust N Z J Med | pmid:269690 |
| Green B et al. | Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby (Macropus eugenii). | 1983 | Aust. J. Biol. Sci. | pmid:6675645 |
| Weber J et al. | [Can zinc stearate cause lung fibrosis? (Case report)]. | 1976 | Beitr Silikoseforsch Pneumokoniose | pmid:990095 |
| Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
| ERWIN J and BLOCH K | POLYUNSATURATED FATTY ACIDS IN SOME PHOTOSYNTHETIC MICROORGANISMS. | 1963 | Biochem Z | pmid:14087318 |
| Robert S et al. | Fatty acid acylation of RNase A using reversed micelles as microreactors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7692851 |
| Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
| Baines DL et al. | Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11676504 |