stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu Z et al. | [Chemical constituents from root bark of Tripterygium hypoglaucum]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22256754 |
Ash MM et al. | Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters. | 2011 | Nutr Res | pmid:21840470 |
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Potta SG et al. | Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. | 2011 | J Microencapsul | pmid:21171818 |
Man TY et al. | Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21406612 |
Arora G et al. | Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. | 2011 | J Adv Pharm Technol Res | pmid:22171313 |
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D'Ambrosio DN et al. | Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. | 2011 | PLoS ONE | pmid:21949825 |
Nurul Syazana MS et al. | Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts. | 2011 | BMC Complement Altern Med | pmid:21943200 |
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Kordyukova LV et al. | Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. | 2011 | Biochim. Biophys. Acta | pmid:21420932 |
Wang L et al. | Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations. | 2011 | AIDS Res Ther | pmid:21385339 |
Salem H et al. | Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler. | 2011 | Int J Nanomedicine | pmid:21383856 |
Nicholls HT et al. | Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. | 2011 | Diabetes | pmid:21378177 |
Intorre F et al. | Differential effect of cheese fatty acid composition on blood lipid profile and redox status in normolipidemic volunteers: a pilot study. | 2011 | Int J Food Sci Nutr | pmid:21591986 |
Gresback R et al. | Combined plasma gas-phase synthesis and colloidal processing of InP/ZnS core/shell nanocrystals. | 2011 | Nanoscale Res Lett | pmid:21711589 |
Desai D et al. | Fatty acid and water-soluble polymer-based controlled release drug delivery system. | 2011 | J Pharm Sci | pmid:21374622 |
Christian F et al. | Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. | 2011 | J. Biol. Chem. | pmid:21177871 |
Su Z et al. | Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine. | 2011 | Mol. Pharm. | pmid:21770405 |
Hayashi Y et al. | Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks. | 2011 | Drug Dev Ind Pharm | pmid:21702729 |
Petelska AD and Figaszewski ZA | The equilibria of phosphatidylcholine-fatty acid and phosphatidylcholine-amine in monolayers at the air/water interface. | 2011 | Colloids Surf B Biointerfaces | pmid:20888195 |
Laus MN et al. | Activation of the plant mitochondrial potassium channel by free fatty acids and acyl-CoA esters: a possible defence mechanism in the response to hyperosmotic stress. | 2011 | J. Exp. Bot. | pmid:20801915 |
Pingali K et al. | Mixing order of glidant and lubricant--influence on powder and tablet properties. | 2011 | Int J Pharm | pmid:21356286 |
Zaki Rizkalla CM et al. | In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. | 2011 | AAPS PharmSciTech | pmid:21800216 |
Roblegg E et al. | Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. | 2011 | Eur J Pharm Biopharm | pmid:21801834 |
Van Hoeck V et al. | Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. | 2011 | PLoS ONE | pmid:21858021 |
El Andaloussi S et al. | Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21748634 |
Li Y et al. | Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. | 2011 | Chem. Commun. (Camb.) | pmid:21755081 |
Tsai MJ et al. | Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations. | 2011 | J Pharm Sci | pmid:20740670 |
Varshosaz J et al. | Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. | 2011 | J Drug Deliv | pmid:22175029 |
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Someshwar K et al. | Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride. | 2011 | Acta Pharm | pmid:21684848 |
Pani NR et al. | Compatibility studies of nateglinide with excipients in immediate release tablets. | 2011 | Acta Pharm | pmid:21684850 |
Němcová-Fürstová V et al. | Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction. | 2011 | Cell. Physiol. Biochem. | pmid:21691070 |
Bazzini AA et al. | Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes. | 2011 | PLoS ONE | pmid:22174812 |
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White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
Farboud ES et al. | Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. | 2011 | Int J Nanomedicine | pmid:21674018 |
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