stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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pmid:9608395 | ||||
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Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
Gupta A et al. | Difference in the lubrication efficiency of bovine and vegetable-derived magnesium stearate during tabletting. | 2009 | AAPS PharmSciTech | pmid:19390976 |
Zhou QT et al. | Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. | 2013 | AAPS PharmSciTech | pmid:23196863 |
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Mir VG et al. | Application of crustacean chitin as a co-diluent in direct compression of tablets. | 2010 | AAPS PharmSciTech | pmid:20238188 |
Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
Cunha TA et al. | Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. | 2013 | AAPS PharmSciTech | pmid:23897034 |
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Zhang SW et al. | A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. | 2014 | AAPS PharmSciTech | pmid:25037732 |
Zaki Rizkalla CM et al. | In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. | 2011 | AAPS PharmSciTech | pmid:21800216 |
Shidhaye SS et al. | Buccal drug delivery of pravastatin sodium. | 2010 | AAPS PharmSciTech | pmid:20300898 |
Räsänen E et al. | A new method to predict flowability using a microscale fluid bed. | 2003 | AAPS PharmSciTech | pmid:15198548 |
Li S et al. | Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. | 2011 | AAPS PharmSciTech | pmid:21811889 |
Waters LJ et al. | Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. | 2011 | AAPS PharmSciTech | pmid:21842309 |
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Khan FN and Dehghan MH | Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. | 2011 | AAPS PharmSciTech | pmid:21879394 |
Swaminathan V and Kildsig DO | An examination of the moisture sorption characteristics of commercial magnesium stearate. | 2001 | AAPS PharmSciTech | pmid:14727865 |
Fernández EG et al. | Rapid development and optimization of tablet manufacturing using statistical tools. | 2008 | AAPS PharmSciTech | pmid:18459048 |
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Kumar R and Sinha VR | Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). | 2017 | AAPS PharmSciTech | pmid:27368921 |
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Thotakura N et al. | Chitosan-Stearic Acid Based Polymeric Micelles for the Effective Delivery of Tamoxifen: Cytotoxic and Pharmacokinetic Evaluation. | 2017 | AAPS PharmSciTech | pmid:27287243 |
Kelidari HR et al. | Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. | 2017 | AAPS PharmSciTech | pmid:27834054 |
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Ahmed TA et al. | Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. | 2012 | AAPS PharmSciTech | pmid:22585373 |