stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with stearic acid?
Related references are published most in these journals:
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What lipids are associated with stearic acid?
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What genes are associated with stearic acid?
Related references are published most in these journals:
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
| Noy N and Zakim D | Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase. | 1985 | Biochemistry | pmid:2931113 |
| Rich MR and Evans JS | Molecular dynamics simulations of adipocyte lipid-binding protein: effect of electrostatics and acyl chain unsaturation. | 1996 | Biochemistry | pmid:8634281 |
| Negash S et al. | Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. | 1996 | Biochemistry | pmid:8784178 |
| Huber AH et al. | Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin. | 2006 | Biochemistry | pmid:17128966 |
| Feix JB et al. | Interactions of 14N:15N stearic acid spin-label pairs: effects of host lipid alkyl chain length and unsaturation. | 1987 | Biochemistry | pmid:2820479 |
| Bach R et al. | Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. | 1988 | Biochemistry | pmid:3166978 |
| Zornetzer GA et al. | The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. | 2010 | Biochemistry | pmid:20014832 |
| Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
| Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
| Pohl EE et al. | Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids. | 2000 | Biochemistry | pmid:10677234 |
| Huang G et al. | Identification of the thiol ester linked lipids in apolipoprotein B. | 1988 | Biochemistry | pmid:3365394 |
| Feix JB et al. | An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. | 1984 | Biochemistry | pmid:6329270 |
| Murate M et al. | Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. | 2010 | Biochemistry | pmid:20433166 |
| Pohl J et al. | Long-chain fatty acid uptake into adipocytes depends on lipid raft function. | 2004 | Biochemistry | pmid:15065861 |
| Woodward H et al. | Isolation, purification, and properties of respiratory mucus glycoproteins. | 1982 | Biochemistry | pmid:7074033 |
| Smaby JM and Brockman HL | Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups. | 1981 | Biochemistry | pmid:7213606 |
| Chen SC et al. | Calorimetric evidence for phase transitions in spin-label lipid bilayers. | 1982 | Biochemistry | pmid:7138849 |
| Davis PJ et al. | Gel to liquid-crystalline transition temperatures of water dispersions of two pairs of positional isomers of unsaturated mixed-acid phosphatidylcholines. | 1981 | Biochemistry | pmid:7260060 |
| HIRSHFIELD IN and KORITZ SB | THE STIMULATION OF PREGNENOLONE SYNTHESIS IN THE LARGE PARTICLES FROM RAT ADRENALS BY SOME AGENTS WHICH CAUSE MITOCHONDRIAL SWELLING. | 1964 | Biochemistry | pmid:14269324 |
| Zornetzer GA et al. | Solution structures of spinach acyl carrier protein with decanoate and stearate. | 2006 | Biochemistry | pmid:16618110 |
| Horváth LI et al. | Exchange rates at the lipid-protein interface of myelin proteolipid protein studied by spin-label electron spin resonance. | 1988 | Biochemistry | pmid:2450570 |
| Gomez GA et al. | Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. | 2004 | Biochemistry | pmid:15096040 |
| Mogelson S and Lange LG | Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. | 1984 | Biochemistry | pmid:6487591 |
| Iot T et al. | Synthesis of a new phosphatidylserine spin-label and calcium-induced lateral phase separation in phosphatidylserine-phosphatidylcholine membranes. | 1975 | Biochemistry | pmid:167814 |
| Ramanadham S et al. | Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. | 1993 | Biochemistry | pmid:8257685 |
| Malykh EV et al. | Effect of hydrophobization of basic pancreatic proteinase inhibitor on the inhibition of bovine trypsin and human leukocyte elastase. | 1998 | Biochemistry Mosc. | pmid:9864442 |
| Prasinou P et al. | Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. | 2017 | Biochim Biophys Acta Biomembr | pmid:28688796 |
| Chen H et al. | Effect of cholesterol on miscibility and phase behavior in binary mixtures with synthetic ceramide 2 and octadecanoic acid. Infrared studies. | 2001 | Biochim. Biophys. Acta | pmid:11406112 |
| Morrow MR et al. | Glycosphingolipid acyl chain order profiles: substituent effects. | 1995 | Biochim. Biophys. Acta | pmid:7756331 |
| Riordan JR et al. | Plasma membrane lipids of human diploid fibroblasts from normal individuals and patients with cystic fibrosis. | 1979 | Biochim. Biophys. Acta | pmid:476136 |
| Woldseth B et al. | Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. | 1993 | Biochim. Biophys. Acta | pmid:8481391 |
| Watanabe S and Sato T | Effects of free fatty acids on the binding of bovine and human serum albumin with steroid hormones. | 1996 | Biochim. Biophys. Acta | pmid:8620023 |
| Sparks JD et al. | Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. | 1997 | Biochim. Biophys. Acta | pmid:9233686 |
| Streichman S et al. | Unique profile for erythrocyte membrane acetylcholinesterase in hereditary spherocytosis. | 1983 | Biochim. Biophys. Acta | pmid:6849970 |
| ELOVSON J | METABOLISM OF SOME MONOHYDROXYSTEARIC ACIDS IN THE INTACT RAT. | 1964 | Biochim. Biophys. Acta | pmid:14194233 |
| Holub BJ | The relative deacylation of different molecular species of endogenous phosphatidylethanolamine in rat liver microsomes by phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:7093298 |
| MENZEL DB and OLCOTT HS | POSITIONAL DISTRIBUTION OF FATTY ACIDS IN FISH AND OTHER ANIMAL LECITHINS. | 1964 | Biochim. Biophys. Acta | pmid:14181289 |
| Slomiany BL et al. | Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. | 1986 | Biochim. Biophys. Acta | pmid:3518803 |
| Morgan H et al. | Proton transport at the monolayer-water interface. | 1991 | Biochim. Biophys. Acta | pmid:1848448 |
| Streichman S et al. | EPR study of the hydrophobic interaction of spectrin with fatty acids. | 1991 | Biochim. Biophys. Acta | pmid:1648396 |
| Møller JK et al. | Effect of nitrosylmyoglobin and saturated fatty acid anions on metmyoglobin-catalyzed oxidation of aqueous methyl linoleate emulsions. | 2002 | Biochim. Biophys. Acta | pmid:11985897 |
| Baker RR and Chang HY | A comparison of lysophosphatidylcholine acyltransferase activities in neuronal nuclei and microsomes isolated from immature rabbit cerebral cortex. | 1981 | Biochim. Biophys. Acta | pmid:7306562 |
| Wang Y et al. | Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. | 2017 | Biochim. Biophys. Acta | pmid:28526351 |
| George M and Chepenik KP | Phospholipase A activities in embryonic palate mesenchyme cells in vitro. | 1985 | Biochim. Biophys. Acta | pmid:3927980 |
| ELOVSON J | CHAIN-SHORTENING OF STEARIC ACID IN THE INTACT RAT. | 1965 | Biochim. Biophys. Acta | pmid:14290835 |
| MCCARTHY RD et al. | THE CONVERSION OF STEARIC ACID TO OLEIC IN FRESHLY SECRETED MILK. | 1965 | Biochim. Biophys. Acta | pmid:14292868 |
| Malmberg P et al. | Localization of lipids in the aortic wall with imaging TOF-SIMS. | 2007 | Biochim. Biophys. Acta | pmid:17240191 |
| Lagrost L | Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. | 1992 | Biochim. Biophys. Acta | pmid:1543738 |
| Mortimer BC et al. | The effect of added monoacylglycerols on the removal from plasma of chylomicron-like emulsions injected intravenously in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713386 |