stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Torres A et al. | Characterization of surface n-alkanes and fatty acids of the epiphytic lichen Xanthoria parietina, its photobiont a green alga Trebouxia sp., and its mycobiont, from the Jerusalem hills. | 2003 | Eur. J. Biochem. | pmid:12752431 |
Garzón Serra Mde L and Villafuerte Robles L | Compactibility of agglomerated mixtures of calcium carbonate and microcrystalline cellulose. | 2003 | Int J Pharm | pmid:12753762 |
Planinsek O and Buckton G | Inverse gas chromatography: considerations about appropriate use for amorphous and crystalline powders. | 2003 | J Pharm Sci | pmid:12761817 |
Lo YL | Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. | 2003 | J Control Release | pmid:12767705 |
Tang HF et al. | [Studies on the chemical constituents from marine brown alga Ishige okamurai (3)]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774370 |
Bulotta A et al. | GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release. | 2003 | J. Lipid Res. | pmid:12777469 |
Ogwal S and Xide TU | Bioavailability and stability of erythromycin delayed release tablets. | 2001 | Afr Health Sci | pmid:12789122 |
Wu PC et al. | Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. | 2003 | Eur J Pharm Sci | pmid:12791413 |
Tholstrup T et al. | Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. | 2003 | Eur J Clin Nutr | pmid:12792657 |
Brunengraber DZ et al. | Influence of diet on the modeling of adipose tissue triglycerides during growth. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12799315 |
del Carmen RamÃrez-Medeles M et al. | Amino acid sequence, biochemical characterization, and comparative modeling of a nonspecific lipid transfer protein from Amaranthus hypochondriacus. | 2003 | Arch. Biochem. Biophys. | pmid:12801509 |
Wu PC et al. | Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose. | 2003 | Int J Pharm | pmid:12818816 |
Mittendorfer B et al. | What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? | 2003 | Diabetes | pmid:12829627 |
Yang L et al. | Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. | 2003 | J. Biol. Chem. | pmid:12829715 |
McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
Lian Z et al. | [Studies on chemical constituents of Choerospondias axillaris]. | 2003 | Zhong Yao Cai | pmid:12858769 |
Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
Duong NH et al. | A homogeneity study using NIR spectroscopy: tracking magnesium stearate in Bohle bin-blender. | 2003 | Drug Dev Ind Pharm | pmid:12889786 |
Ceschel GC et al. | Degradation of components in drug formulations: a comparison between HPLC and DSC methods. | 2003 | J Pharm Biomed Anal | pmid:12899995 |
Jin F et al. | Oxidation reaction of high molecular weight carboxylic acids in supercritical water. | 2003 | Environ. Sci. Technol. | pmid:12901673 |
Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
Yassin AA et al. | Effect of enzymatic interesterification on melting point of palm olein. | 2003 | Appl. Biochem. Biotechnol. | pmid:12909731 |
Lyon RC et al. | Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. | 2002 | AAPS PharmSciTech | pmid:12916932 |
Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
MuzÃková J and Horácek J | [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. | 2003 | Ceska Slov Farm | pmid:12924068 |
Ohta KM et al. | Effect of geometric structure and surface wettability of glidant on tablet hardness. | 2003 | Int J Pharm | pmid:12927389 |
Bracconi P et al. | Structural properties of magnesium stearate pseudopolymorphs: effect of temperature. | 2003 | Int J Pharm | pmid:12927393 |
El-Assaad W et al. | Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. | 2003 | Endocrinology | pmid:12933690 |
Liu CL et al. | [Effect of surface decoration on the spectral characteristics of alpha-Fe2O3 ultrafine particles]. | 2003 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12939995 |
Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
Dave PC et al. | Calculating order parameter profiles utilizing magnetically aligned phospholipid bilayers for 2H solid-state NMR studies. | 2003 Sep-Nov | Solid State Nucl Magn Reson | pmid:12943910 |
Sun Y et al. | [The study of the microwave reaction of stearic acid and pentyl amine]. | 2000 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12945403 |
Zeng F et al. | [Analysis on infrared spectrum of human body gallstone with comparative method]. | 2001 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12947655 |
Kajikawa M et al. | MpFAE3, a beta-ketoacyl-CoA synthase gene in the liverwort Marchantia polymorpha L., is preferentially involved in elongation of palmitic acid to stearic acid. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12951498 |
Topping DL and Targ ME | Time-course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. | 1975 | Horm. Res. | pmid:130333 |
DOXIADIS SA | Procaine penicillin with aluminium monostearate; infrequent injections for children. | 1953 | Lancet | pmid:13085786 |
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DUNCOMBE WG and GLASCOCK RF | The contribution of dietary stearic acid to milk fat. | 1954 | Biochem. J. | pmid:13172205 |
SHAFER JK and SMITH CA | Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. | 1954 | Bull. World Health Organ. | pmid:13182589 |
MUNZEL K and AMMANN R | [Washable oil-water ointments. V. Complex-emulsified ointments; differences between stearate- and complex-emulsified ointments]. | 1954 | Pharm Acta Helv | pmid:13194353 |
SCRIBANTE P and FAVARGER P | [Studies on digestibility of stearic acid and its glyceric esters in rat]. | 1954 | Helv Physiol Pharmacol Acta | pmid:13201008 |
Boza J et al. | Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1322471 |
BERGSTROM S et al. | Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. | 1954 | Biochem. J. | pmid:13230010 |
GLASCOCK RF and REINIUS LR | Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. | 1954 | Biochem. J. | pmid:13230049 |