stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Boiret M et al. | Setting local rank constraints by orthogonal projections for image resolution analysis: application to the determination of a low dose pharmaceutical compound. | 2015 | Anal. Chim. Acta | pmid:26388474 |
Veit M and Siche S | S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? | 2015 | Vaccine | pmid:26387429 |
Wang D et al. | One-pot synthesized hierarchical zeolite supported metal nanoparticles for highly efficient biomass conversion. | 2015 | Chem. Commun. (Camb.) | pmid:26361087 |
Xu L et al. | The Surface Modification and Antimicrobial Activity of Basic Magnesium Hypochlorite Nanoparticles. | 2015 | J Nanosci Nanotechnol | pmid:26353638 |
Zhang X et al. | Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. | 2015 | J Nanosci Nanotechnol | pmid:26353513 |
Bhattacharya S et al. | Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. | 2015 | Plant Physiol. Biochem. | pmid:26351151 |
Seethamraju S et al. | Reactive interlayer based ultra-low moisture permeable membranes for organic photovoltaic encapsulation. | 2015 | Phys Chem Chem Phys | pmid:26278515 |
Yang W et al. | Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging. | 2015 | ACS Appl Mater Interfaces | pmid:26257133 |
Zhong T et al. | Effects of ultrasound treatment on lipid self-association and properties of methylcellulose/stearic acid blending films. | 2015 | Carbohydr Polym | pmid:26256202 |
He H et al. | VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. | 2015 | Int J Pharm | pmid:26253378 |
Xu W et al. | Bilayers at High pH in the Fatty Acid Soap Systems and the Applications for the Formation of Foams and Emulsions. | 2015 | J Phys Chem B | pmid:26237503 |
Hoffmann M et al. | Investigation into process-induced de-aggregation of cohesive micronised API particles. | 2015 | Int J Pharm | pmid:26235919 |
Gong X et al. | Dependence of tablet brittleness on tensile strength and porosity. | 2015 | Int J Pharm | pmid:26226338 |
Liu G et al. | Cell membrane-inspired polymeric micelles as carriers for drug delivery. | 2015 | Biomater Sci | pmid:26222292 |
Qu L et al. | Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. | 2015 | Eur J Pharm Sci | pmid:26215464 |
Kelidari HR et al. | Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. | 2015 | Colloids Surf B Biointerfaces | pmid:25797482 |
Seyedi S et al. | Improving the physical and moisture barrier properties of Lepidium perfoliatum seed gum biodegradable film with stearic and palmitic acids. | 2015 | Int. J. Biol. Macromol. | pmid:25795389 |
Su Y et al. | Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy. | 2015 | Mol. Pharm. | pmid:25751168 |
Phaechamud T et al. | Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. | 2015 | Mater Sci Eng C Mater Biol Appl | pmid:25746264 |
Jedinger N et al. | Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids. | 2015 | Eur J Pharm Biopharm | pmid:25733499 |
Castellanos-Tapia L et al. | Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. | 2015 | Nutr Res | pmid:25727313 |
Kerth CR et al. | Consumer sensory evaluation, fatty acid composition, and shelf-life of ground beef with subcutaneous fat trimmings from different carcass locations. | 2015 | Meat Sci. | pmid:25688688 |
Tai Z et al. | Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo. | 2015 | Biomacromolecules | pmid:25686200 |
Thakkar A et al. | Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. | 2015 | Int. J. Oncol. | pmid:25652350 |
Sagiri SS et al. | Stearic acid based oleogels: a study on the molecular, thermal and mechanical properties. | 2015 | Mater Sci Eng C Mater Biol Appl | pmid:25579972 |
Rana S et al. | A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. | 2015 | J Control Release | pmid:25575863 |
Wei X et al. | Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. | 2015 | Carbohydr Polym | pmid:25542116 |
Zeng Q et al. | Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. | 2015 | J Control Release | pmid:25540903 |
Piantoni P et al. | Milk production responses to dietary stearic acid vary by production level in dairy cattle. | 2015 | J. Dairy Sci. | pmid:25529423 |
Vercruysse J et al. | Use of a continuous twin screw granulation and drying system during formulation development and process optimization. | 2015 | Eur J Pharm Biopharm | pmid:25528462 |
Schrank S et al. | The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. | 2015 | Int J Pharm | pmid:25526671 |
Foraita S et al. | Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. | 2015 | Chemistry | pmid:25504844 |
Cantor SL et al. | Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. | 2015 | Drug Dev Ind Pharm | pmid:25000481 |
Qu L et al. | Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. | 2015 | Drug Dev Ind Pharm | pmid:24738790 |
Vervaeck A et al. | Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. | 2015 | Eur J Pharm Biopharm | pmid:26428938 |
Nandini PT et al. | Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles. | 2015 | Drug Deliv | pmid:24283392 |
Chen Q et al. | Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. | 2015 | Artif Cells Nanomed Biotechnol | pmid:24093764 |
Senyilmaz D et al. | Regulation of mitochondrial morphology and function by stearoylation of TFR1. | 2015 | Nature | pmid:26214738 |
Gotoh K et al. | Introduction of Atmospheric Pressure Plasma to Aqueous Detergent Processes. | 2015 | J Oleo Sci | pmid:26179001 |
Astanina K et al. | Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells. | 2015 | Sci Rep | pmid:26095213 |
VranÃková B et al. | Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods. | 2015 | Biomed Res Int | pmid:26075249 |
Patil PS et al. | Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. | 2015 | Nat Commun | pmid:26037164 |
Onishi H et al. | In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. | 2015 | Biol. Pharm. Bull. | pmid:26027834 |
Rehman M et al. | Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. | 2015 | Int J Nanomedicine | pmid:25897224 |
Harding SV et al. | Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. | 2015 | BMC Res Notes | pmid:25879456 |
Silva-Neta IC et al. | Expression of genes related to tolerance to low temperature for maize seed germination. | 2015 | Genet. Mol. Res. | pmid:25867416 |
Jung SW et al. | Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. | 2015 | PLoS ONE | pmid:25793403 |
Othman AR et al. | Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. | 2015 | BMC Complement Altern Med | pmid:25652309 |
Aardema H et al. | Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. | 2015 | J. Dairy Sci. | pmid:25648816 |
Ma W et al. | Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. | 2015 | Am. J. Clin. Nutr. | pmid:25527759 |