stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Venho VM et al. | The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. | 1987 | Methods Find Exp Clin Pharmacol | pmid:3683018 |
El Andaloussi S et al. | Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21748634 |
Andaloussi SE et al. | Application of PepFect peptides for the delivery of splice-correcting oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21053143 |
Peng Q et al. | A novel esterase gene cloned from a metagenomic library from neritic sediments of the South China Sea. | 2011 | Microb. Cell Fact. | pmid:22067554 |
Yu WL et al. | Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. | 2011 | Microb. Cell Fact. | pmid:22047615 |
Shim SK et al. | Analysis of cellular fatty acids in Orientia tsutsugamushi as taxonomic markers. | 2005 | Microbiol. Immunol. | pmid:15840959 |
Suo T et al. | Fixed-point and stratified analysis of the fine structure and composition of five gallstones with Fourier transform infrared (FT-IR) specular reflection spectroscopy. | 2012 | Microsc. Res. Tech. | pmid:21809418 |
Richter K et al. | Localization of fatty acids with selective chain length by imaging time-of-flight secondary ion mass spectrometry. | 2007 | Microsc. Res. Tech. | pmid:17393479 |
Krogmann A et al. | Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids. | 2011 | Microvasc. Res. | pmid:21112343 |
Staiger K et al. | Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. | 2009 | Microvasc. Res. | pmid:19327373 |
Udod VM et al. | [Microbial breakdown of stearox-6 and a study of the genetic determination of the nature of the degradative activity]. | 1987 May-Jun | Mikrobiol. Zh. | pmid:3150493 |
Diani F et al. | [Fatty acid composition of the cervical mucus obtained during ovulation and at the term of pregnancy]. | 1998 | Minerva Ginecol | pmid:9866950 |
Albanese A et al. | [Preparation of patients in diagnostic contrast radiography of the urinary and bile tracts and the large intestine]. | 1981 | Minerva Med. | pmid:7290472 |
KELLERSHOHN C and BENICHOUX R | [Comparative study of the drainage through the lymphatic vessels of a radioactive fat, ethyl diiodosterate labeled with I 131, and a radioactive colloidal substance, colloidal gold 198]. | 1958 May-Jun | Minerva Nucl | pmid:13565747 |
Dobrzyn P et al. | Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation. | 2012 | Mitochondrion | pmid:21664496 |
Ahn J et al. | Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. | 2012 | Mol Nutr Food Res | pmid:22968990 |
Rideout TC et al. | Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. | 2010 | Mol Nutr Food Res | pmid:20333723 |
Park KH et al. | Elaidic acid (EA) generates dysfunctional high-density lipoproteins and consumption of EA exacerbates hyperlipidemia and fatty liver change in zebrafish. | 2014 | Mol Nutr Food Res | pmid:24863413 |
Morita YS and Englund PT | Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate. | 2001 | Mol. Biochem. Parasitol. | pmid:11420102 |
Florin-Christensen J et al. | Phosphatidylcholine formation is the predominant lipid biosynthetic event in the hemoparasite Babesia bovis. | 2000 | Mol. Biochem. Parasitol. | pmid:10743618 |
Imae R et al. | Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. | 2010 | Mol. Biol. Cell | pmid:20668164 |
Harvey DJ | Picolinyl esters for the structural determination of fatty acids by GC/MS. | 1998 | Mol. Biotechnol. | pmid:9951705 |
Garba L et al. | Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. | 2016 | Mol. Biotechnol. | pmid:27629791 |
de Alaniz MJ and Marra CA | Role of delta 9 desaturase activity in the maintenance of high levels of monoenoic fatty acids in hepatoma cultured cells. | 1994 | Mol. Cell. Biochem. | pmid:7845382 |
Catalá A et al. | Interaction of rat liver microsomes containing saturated or unsaturated fatty acids with fatty acid binding protein: peroxidation effect. | 1994 | Mol. Cell. Biochem. | pmid:7845387 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Gentile CL et al. | Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin. | 2010 | Mol. Cell. Biochem. | pmid:20607591 |
Wei Y et al. | Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. | 2009 | Mol. Cell. Biochem. | pmid:19444596 |
Romanowicz L and Bańkowski E | Sphingolipids of human umbilical cord vein and their alteration in preeclampsia. | 2010 | Mol. Cell. Biochem. | pmid:20155487 |
Doignon F et al. | Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. | 2015 | Mol. Cell. Biol. | pmid:26711260 |
Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
Li LO et al. | Early hepatic insulin resistance in mice: a metabolomics analysis. | 2010 | Mol. Endocrinol. | pmid:20150186 |
Stryjecki C et al. | Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation. | 2012 | Mol. Genet. Metab. | pmid:22209225 |
Williams EE et al. | The curvature and cholesterol content of phospholipid bilayers alter the transbilayer distribution of specific molecular species of phosphatidylethanolamine. | 2000 Jul-Sep | Mol. Membr. Biol. | pmid:11128974 |
Salem N and Niebylski CD | The nervous system has an absolute molecular species requirement for proper function. | 1995 Jan-Mar | Mol. Membr. Biol. | pmid:7767372 |
Dziewulska A et al. | Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle. | 2012 | Mol. Membr. Biol. | pmid:22881371 |
Zhang YM et al. | A Pseudomonas aeruginosa transcription factor that senses fatty acid structure. | 2007 | Mol. Microbiol. | pmid:17877713 |
Zhu K et al. | Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa. | 2006 | Mol. Microbiol. | pmid:16573679 |
Su Y et al. | Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy. | 2015 | Mol. Pharm. | pmid:25751168 |
Yang Y et al. | Ligand-directed stearic acid grafted chitosan micelles to increase therapeutic efficacy in hepatic cancer. | 2015 | Mol. Pharm. | pmid:25495890 |
Yi HX et al. | Effect of anionic PEGylated polypeptide on gene transfection mediated by glycolipid conjugate micelles. | 2015 | Mol. Pharm. | pmid:25490413 |
Thakral NK et al. | Compression-induced crystallization of amorphous indomethacin in tablets: characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. | 2015 | Mol. Pharm. | pmid:25438193 |
Alshamsan A et al. | Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine. | 2009 Jan-Feb | Mol. Pharm. | pmid:19053537 |
Hu FQ et al. | pH triggered doxorubicin delivery of PEGylated glycolipid conjugate micelles for tumor targeting therapy. | 2012 | Mol. Pharm. | pmid:22827551 |
Su Z et al. | Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine. | 2011 | Mol. Pharm. | pmid:21770405 |
Koranne S et al. | Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry. | 2017 | Mol. Pharm. | pmid:28195490 |
Walker S et al. | Synthesis, processing and solid state excipient interactions of cucurbit[6]uril and its formulation into tablets for oral drug delivery. | 2010 | Mol. Pharm. | pmid:20669974 |
Nie H et al. | Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. | 2016 | Mol. Pharm. | pmid:27542728 |
Yan J et al. | Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. | 2013 | Mol. Pharm. | pmid:23679858 |
Yuan H et al. | Stearic acid-g-chitosan polymeric micelle for oral drug delivery: in vitro transport and in vivo absorption. | 2011 | Mol. Pharm. | pmid:21138243 |