stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Obesity, Abdominal D056128 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Yaws D015001 4 associated lipids
Whooping Cough D014917 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Urticaria D014581 13 associated lipids
Urethritis D014526 9 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Tremor D014202 15 associated lipids
Thrombosis D013927 49 associated lipids
Tenosynovitis D013717 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Seizures D012640 87 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Rosacea D012393 13 associated lipids
Relapsing Fever D012061 3 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Prostatic Diseases D011469 4 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Pneumoconiosis D011009 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Otitis Media D010033 12 associated lipids
Occupational Diseases D009784 42 associated lipids
Neuroblastoma D009447 66 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Lymphoma D008223 18 associated lipids
Lymphadenitis D008199 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Liver Neoplasms D008113 8 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leprosy D007918 8 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Ischemia D007511 18 associated lipids
Insulinoma D007340 28 associated lipids
Insulin Resistance D007333 99 associated lipids
Infertility D007246 3 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Hypothyroidism D007037 32 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Gonorrhea D006069 7 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Foreign Bodies D005547 5 associated lipids
Fatty Liver D005234 48 associated lipids
Edema D004487 152 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Dermatitis D003872 30 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Chancroid D002602 4 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cattle Diseases D002418 24 associated lipids
Calculi D002137 3 associated lipids
Burns D002056 34 associated lipids
Bronchitis D001991 6 associated lipids
Breast Neoplasms D001943 24 associated lipids
Brain Edema D001929 20 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Bacterial Infections D001424 21 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Olfaction Disorders D000857 17 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Amnesia D000647 12 associated lipids
Alzheimer Disease D000544 76 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Adenoma D000236 40 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Liu Q et al. High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing. 2002 Plant Physiol. pmid:12177486
Li C et al. Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway. 2002 Plant Physiol. pmid:12226528
Salzman RA et al. Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses. 2005 Plant Physiol. pmid:15863699
Desbrosses GG et al. Lotus japonicus metabolic profiling. Development of gas chromatography-mass spectrometry resources for the study of plant-microbe interactions. 2005 Plant Physiol. pmid:15749991
Clemente TE and Cahoon EB Soybean oil: genetic approaches for modification of functionality and total content. 2009 Plant Physiol. pmid:19783644
Sorigué D et al. Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. 2016 Plant Physiol. pmid:27288359
Do PT et al. The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. 2010 Plant Physiol. pmid:20841452
Pollard MR and Stumpf PK Biosynthesis of C(20) and C(22) Fatty Acids by Developing Seeds of Limnanthes alba: CHAIN ELONGATION AND Delta5 DESATURATION. 1980 Plant Physiol. pmid:16661496
Ashworth EN and Christiansen MN Effect of Temperature and BASF 13 338 on the Lipid Composition and Respiration of Wheat Roots. 1981 Plant Physiol. pmid:16661741
Lem NW and Stumpf PK In Vitro Fatty Acid Synthesis and Complex Lipid Metabolism in the Cyanobacterium, Anabaena Variabilis: II. Acyl Transfer and Complex Lipid Formation. 1984 Plant Physiol. pmid:16663690
Roughan PG Phosphatidylglycerol and chilling sensitivity in plants. 1985 Plant Physiol. pmid:16664127
Lakhssassi N et al. Stearoyl-Acyl Carrier Protein Desaturase Mutations Uncover an Impact of Stearic Acid in Leaf and Nodule Structure. 2017 Plant Physiol. pmid:28461402
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
Salas JJ et al. The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. 2008 Plant Physiol. Biochem. pmid:18023195
Ghosh SK et al. Characterization and cloning of a stearoyl/oleoyl specific fatty acyl-acyl carrier protein thioesterase from the seeds of Madhuca longifolia (latifolia). 2007 Plant Physiol. Biochem. pmid:17977002
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Fernández-Moya V et al. Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. 2003 Planta pmid:12624771
Liu J et al. Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. 2012 Planta pmid:22855030
Su BN et al. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. 2002 Planta Med. pmid:12494342
Dantas da Silva LL et al. Antibacterial activity of a stearic acid derivative from Stemodia foliosa. 2002 Planta Med. pmid:12494347
Kalinina OV et al. Combinations of protein-chemical complex structures reveal new targets for established drugs. 2011 PLoS Comput. Biol. pmid:21573205
Kinnings SL et al. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. 2009 PLoS Comput. Biol. pmid:19578428
Toubiana D et al. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. 2012 PLoS Genet. pmid:22479206
Yang P et al. Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. 2012 PLoS ONE pmid:22536429
Milicic A et al. Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. 2012 PLoS ONE pmid:22470545
Mason P et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. 2012 PLoS ONE pmid:22457791
Olivieri C et al. Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. 2012 PLoS ONE pmid:22457789
Schaab M et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. 2012 PLoS ONE pmid:22545089
Steidl S et al. Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. 2011 PLoS ONE pmid:22102904
Meissner M et al. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. 2011 PLoS ONE pmid:22087215
Ruiz M et al. A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. 2012 PLoS ONE pmid:23056435
Oosterveer MH et al. High fat feeding induces hepatic fatty acid elongation in mice. 2009 PLoS ONE pmid:19557132
Bailey JA et al. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. 2011 PLoS ONE pmid:21799757
Matsui H et al. Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. 2012 PLoS ONE pmid:22413010
Trupp M et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. 2012 PLoS ONE pmid:22808006
Brown JD et al. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. 2011 PLoS ONE pmid:21750705
Fernandez C et al. Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. 2011 PLoS ONE pmid:21738729
Ishida Y et al. Fatty acid solubilizer from the oral disk of the blowfly. 2013 PLoS ONE pmid:23326317
Sharma P et al. Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. 2013 PLoS ONE pmid:23326499
Guan Q et al. In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles. 2017 PLoS ONE pmid:28334044
Flowers MT et al. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. 2011 PLoS ONE pmid:21573029
A J et al. Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. 2010 PLoS ONE pmid:20949032
Normand-Lauzière F et al. Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. 2010 PLoS ONE pmid:20532041
Carrero-Colón M et al. Mutations in SACPD-C result in a range of elevated stearic acid concentration in soybean seed. 2014 PLoS ONE pmid:24846334
Van Hoeck V et al. Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. 2011 PLoS ONE pmid:21858021
Lee DM et al. Oxidative stress and inflammation in renal patients and healthy subjects. 2011 PLoS ONE pmid:21829457
Jiang L et al. Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway. 2009 PLoS ONE pmid:19727392
Deb C et al. A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. 2009 PLoS ONE pmid:19562030
Pérez-Berná AJ et al. Screening a peptide library by DSC and SAXD: comparison with the biological function of the parent proteins. 2009 PLoS ONE pmid:19194494
Pereira MG et al. Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. 2011 PLoS ONE pmid:21818313