stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Yu S et al. | Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. | 1995 | Am. J. Clin. Nutr. | pmid:7733039 |
Pandey M et al. | Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder. | 1995 | J Surg Oncol | pmid:7745974 |
Blechert S et al. | The octadecanoic pathway: signal molecules for the regulation of secondary pathways. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7753776 |
Morrow MR et al. | Glycosphingolipid acyl chain order profiles: substituent effects. | 1995 | Biochim. Biophys. Acta | pmid:7756331 |
Thompson W and MacDonald G | Cytidine diphosphate diglyceride of bovine brain. Positional distribution of fatty acids and analysis of major molecular species. | 1976 | Eur. J. Biochem. | pmid:776622 |
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Fujimoto Y et al. | Effects of fatty acyl coenzyme A esters on lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784474 |
Lai HC et al. | Alteration of plasma lipids in the rat by fractionation of modified milk fat (butterfat). | 1995 | J. Dairy Sci. | pmid:7790571 |
Aggarwal M et al. | The effect of Cd2+ on lipid components of sunflower (Helianthus annuus L.) seeds. | 1995 | Plant Foods Hum Nutr | pmid:7792263 |
Shoji Y et al. | Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene. | 1994 | J. Pharm. Pharmacol. | pmid:7815276 |
Kaewvichit S and Tucker IG | The release of macromolecules from fatty acid matrices: complete factorial study of factors affecting release. | 1994 | J. Pharm. Pharmacol. | pmid:7837038 |
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Scholz WK | An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons. | 1994 | J. Neurochem. | pmid:7908944 |
Young AC et al. | Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. | 1994 | Structure | pmid:7922029 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
Awad AB et al. | In vitro activation and inhibition of rat colonic phospholipase D by fatty acids. | 1994 | Cancer Lett. | pmid:7954345 |
Shenai JP and Chytil F | Effect of maternal dexamethasone treatment on fetal lung vitamin A stores in the perinatal rat. | 1994 | Int J Vitam Nutr Res | pmid:7960497 |
Ikeda I et al. | Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7965216 |
Adewusi SR and Ilori MO | Nutritional evaluation of spent grains from sorghum malts and maize grit. | 1994 | Plant Foods Hum Nutr | pmid:7971786 |
Fuller CJ and Jialal I | Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. | 1994 | Am. J. Clin. Nutr. | pmid:7977141 |
Denke MA | Effects of cocoa butter on serum lipids in humans: historical highlights. | 1994 | Am. J. Clin. Nutr. | pmid:7977142 |
Emken EA | Metabolism of dietary stearic acid relative to other fatty acids in human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977144 |
Kris-Etherton PM and Mustad VA | Chocolate feeding studies: a novel approach for evaluating the plasma lipid effects of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977145 |
Dougherty RM et al. | Total and low-density-lipoprotein cholesterol lipoprotein fractions and fecal fatty acid excretion of men consuming diets containing high concentrations of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977147 |
Denke MA | Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet. | 1994 | Am. J. Clin. Nutr. | pmid:7977148 |
Hoak JC | Stearic acid, clotting, and thrombosis. | 1994 | Am. J. Clin. Nutr. | pmid:7977149 |
Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
Schoene NW et al. | Dissimilar responses of platelets to dietary stearic and palmitic acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977151 |
Metabolic Consequences of Stearic Acid Relative to Other Long-Chain Fatty Acids, Atlanta, Georgia, November 5-6, 1993 and Chocolate in Perspective: Cocoa Butter, a Unique Saturated Fat, Dallas, Texas, February 9, 1994. Symposium proceedings. | 1994 | Am. J. Clin. Nutr. | pmid:7977155 | |
Vanderveen JE | Regulatory history for stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977156 |
Grundy SM | Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977157 |
Kritchevsky D | Stearic acid metabolism and atherogenesis: history. | 1994 | Am. J. Clin. Nutr. | pmid:7977159 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Ellingson JS and Seenaiah B | The selective use of stearoyl-polyunsaturated molecular species of phosphatidylcholine and phosphatidylethanolamine for the synthesis of phosphatidylserine. | 1994 | Biochim. Biophys. Acta | pmid:8011673 |
Hoebeke M et al. | Quenching of merocyanine 540 triplet state by nitroxyl radicals in liposomal systems: a laser flash photolysis study. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:8014755 |
Vestemar V et al. | Binding of (+)- and (-)-isomers and racemate of etomoxir to human serum albumin and effect of stearic acid and stanozolol. | 1994 | J Pharm Sci | pmid:8046600 |
Sargent JR et al. | Nervonic acid and demyelinating disease. | 1994 | Med. Hypotheses | pmid:8072429 |
Sylvester PW et al. | Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. | 1994 | Exp. Cell Res. | pmid:8082717 |
Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
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Redgrave TG et al. | The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. | 1994 | Biochim. Biophys. Acta | pmid:8117751 |
Burdick S et al. | Different mechanisms of uptake of stearic acid and cholesterol into rabbit jejunal brush border membrane vesicles. | 1993 | Lipids | pmid:8121247 |
Rule DC | Effects of dietary fatty acid composition on glycerophosphate acyltransferase activity in rat adipose tissue and liver. | 1994 | Int. J. Biochem. | pmid:8138047 |