stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Arai T and Hosoi Y | [Determination of magnesium stearate in pharmaceutical preparations using derivatization with 2-nitrophenylhydrazine and HPLC]. | 2005 | Yakugaku Zasshi | pmid:15738629 |
Nadai M et al. | [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. | 1987 | Yakugaku Zasshi | pmid:3437396 |
Iwao Y | [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. | 2015 | Yakugaku Zasshi | pmid:26423868 |
KAKEMI K et al. | [STUDIES ON SUCROSE ESTERS. 3. EFFECT OF SUCROSE ESTERS ON THE ABSORPTION OF DRUGS FROM THE ALIMENTARY TRACT]. | 1964 | Yakugaku Zasshi | pmid:14266554 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
Chen JL et al. | Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. | 2010 | World J. Gastroenterol. | pmid:21155010 |
Liu Z et al. | Changes in the electron paramagnetic resonance spectra of albumin-associated spin-labeled stearic acid as a diagnostic parameter of colorectal cancer. | 2013 | World J Surg Oncol | pmid:24025321 |
Miranda LA et al. | Performance of UASB and DAEB reactors in the anaerobic digestion of synthetic wastewater containing sodium oleate and sodium stereate. | 2006 | Water Sci. Technol. | pmid:16939093 |
Alves MM et al. | Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability. | 2001 | Water Res. | pmid:11257881 |
Lalman JA and Bagley DM | Anaerobic degradation and methanogenic inhibitory effects of oleic and stearic acids. | 2001 | Water Res. | pmid:11471698 |
Kosukhin AB et al. | [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2741412 |
Zaridze DG et al. | [Fatty acid composition of phospholipids of erythrocyte membranes and risk of breast cancer]. | 1990 | Vopr Onkol | pmid:2126901 |
Bridges CD et al. | Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids. | 1984 | Vision Res. | pmid:6543481 |
MacDonald RC et al. | Inhibition of sendai virus-induced hemolysis by long chain fatty acids. | 1984 | Virology | pmid:6324464 |
Nozawa CM and Apostolov K | Increase in the saturation of C18 fatty acids induced by coxsackie B6 virus in Vero cells. | 1982 | Virology | pmid:6285601 |
Kordyukova LV et al. | Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. | 2010 | Virology | pmid:20006369 |
Lavergne SN et al. | Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. | 2016 | Vet. Dermatol. | pmid:26748887 |
Veit M and Siche S | S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? | 2015 | Vaccine | pmid:26387429 |
Colmano G et al. | Activated silver coatings for surgical implants. | 1979 | Va Med | pmid:316624 |
Yim B et al. | Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. | 2002 | Ultrason Sonochem | pmid:12219583 |